Trials Sponsors Conditions Drugs Pricing

Conditions

Schizophrenia

Keywords

SchizophreniaOxidative stressMitochondria

Outcome Measures

Primary Outcomes (2)

Serum oxidative stress
serum malondialdehyde (MDA) content, serum free thiols, serum glutathione, catalase, Superoxide dismutase, glutathione peroxidase, proapoptotic markers (bad and bax) and antiapoptotic markers (bcl-2 and bcl-x1), quantification of mitochondrial DNA
15 months
DISC1 gene polymorphism
15 months

Secondary Outcomes (4)

PANSS score
15 months
Obesity
15 months
Metabolic syndrome
15 months
Drug response
15 months

Study Arms (1)

Schizophrenia

Eligibility Criteria

Age18 Years - 65 Years

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

This study will be conducted in our clinical setting. By a semi-structured interview for DSM-IV criteria, about 300 schizophrenic patients will be recruited in this study.

You may qualify if:

Schizophrenic patients will be recruited in psychiatric inpatients and outpatients departments according to DSM-IV criteria by a semi-structured interview. The assessment will be done by two senior psychiatrists. The intra- rater and inter-rater reliability will be done before this project started.

Sponsors & Collaborators

Chang Gung Memorial Hospital
Otherlead

Study Sites (1)

Department of Psychiatry, Chang Gung Memorial Hospital

Kaohsiung City, Taiwan

Biospecimen

Retention: SAMPLES WITH DNA

Blood

MeSH Terms

Conditions

Schizophrenia

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic DisordersMental Disorders

Study Officials

Tiao-Lai Huang, M.D.
Chang-Gung Memorial Hospital, Kaohsiung
PRINCIPAL INVESTIGATOR

Enrollment

77 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: CASE ONLY
Time Perspective: PROSPECTIVE
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Head of Department of Psychiatry

Study Record Dates

First Submitted

July 10, 2011

First Posted

November 24, 2011

Study Start

August 2009

Date type not reported

This date has not been verified as actual or estimated.

Mitochondria and Schizophrenia: Effects of Antipsychotic Drugs

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (2)

Secondary Outcomes (4)

Study Arms (1)

Schizophrenia

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (2)

Secondary Outcomes (4)

Study Arms (1)

Schizophrenia

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations