NCT01479244

Brief Summary

Purpose of this trial:

  1. 1.To assess the efficacy and safety of NeuVax™ administered with adjuvant Leukine® (sargramostim, GM-CSF).
  2. 2.To evaluate and compare the disease free survival (DFS) in the vaccinated and control subjects.

Trial Health

98
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
758

participants targeted

Target at P75+ for phase_3

Timeline
Completed

Started Nov 2011

Longer than P75 for phase_3

Geographic Reach
13 countries

197 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2011

Completed
19 days until next milestone

First Submitted

Initial submission to the registry

November 20, 2011

Completed
4 days until next milestone

First Posted

Study publicly available on registry

November 24, 2011

Completed
4.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 21, 2016

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 21, 2016

Completed
Last Updated

February 27, 2017

Status Verified

February 1, 2017

Enrollment Period

4.9 years

First QC Date

November 20, 2011

Last Update Submit

February 23, 2017

Conditions

Keywords

HER2low or intermediatebreast cancernode-positive tumors

Outcome Measures

Primary Outcomes (1)

  • Comparison of DFS in vaccine treated patients and control patients

    The primary objective is to compare the DFS in subjects with operable early-stage, node-positive breast cancer who receive standard of care multimodality therapy plus NeuVax™ as the treatment group or standard of care multimodality therapy plus the vaccine adjuvant, Leukine® as the control group.

    36 months

Secondary Outcomes (1)

  • Assessment of DFS and OS at 3, 5 and 10 years in vaccine and control groups, respectively; assessment of safety

    3 through 10 years

Study Arms (2)

NeuVax™

EXPERIMENTAL

NeuVax™ in WFI solution with Leukine®

Biological: NeuVax™ vaccine

Leukine®

ACTIVE COMPARATOR

Leukine® with WFI

Biological: Leukine® (sargramostim, GM-CSF) and water for injection

Interventions

E75 peptide acetate (HER2/neu p366-379) in WFI (1.5 mg/mL) mixed with 250 micrograms Leukine® (sargramostim, GM-CSF), will be administered in intradermal injections, in four divided doses (4 sites on upper thigh) once a month, for six consecutive months. At the end of the six months, NeuVax™ vaccine boosters will be given the same way once every six months for the next five times (totaling 36 months).

Also known as: E75 peptide acetate , WFI, sargramostim, GM-CSF
NeuVax™

Leukine® 250 micrograms in water for injection, will be administered in intradermal injections, in four divided doses (4 sites on upper thigh) once a month, for six consecutive months. At the end of the six months, boosters inoculations will be given the same way once every six months for the next five times (totaling 36 months).

Also known as: Leukine®
Leukine®

Eligibility Criteria

Age18 Years+
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Pathological diagnosis of invasive adenocarcinoma of the breast
  • Breast cancer completely excised, or patient receiving neoadjuvant therapy prior to surgery
  • One of these 2 surgical treatments and axillary staging with sentinel lymph node dissection or axillary dissection level I/II:
  • Total mastectomy-patients with a positive sentinel lymph node must have undergone a completion axillary dissection level I/II
  • BCS (lumpectomy)-patients with a positive sentinel lymph node must have undergone a completion axillary dissection level I/II unless they had clinically node negative T1-T2 tumors and fewer than 3 involved lymph nodes
  • Node-positive disease
  • Primary tumor stage T1-3 at initial diagnosis
  • HER2 negative (HER2 1+ by IHC or HER2 2+ by IHC/FISH)
  • HLA-A2 or HLA-A3 haplotype
  • Completed NCCN approved neo-adjuvant/adjuvant chemotherapy or both
  • Completed radiation therapy
  • No evidence of disease
  • Able and willing (or have legal representative) to understand the study and provide consent

You may not qualify if:

  • Bilateral breast malignancy or suspicious mass in opposite breast
  • Inflammatory breast malignancy
  • History of prior breast cancer, ductal carcinoma in situ
  • Prior trastuzumab therapy
  • New York Heart Association Stage 3 or 4 cardiac disease
  • Sensory/motor neuropathy ≥ Grade 2
  • Autoimmune diseases or immune deficiency disease
  • Subjects on chronic steroid therapy, other immunosuppressive therapy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (197)

Alabama Oncology

Bessemer, Alabama, 35022, United States

Location

Physicians Pain Specialists of Alabama, P.C.

Mobile, Alabama, 36606, United States

Location

Pain Centers Nationwide

Peoria, Arizona, 83582, United States

Location

Valley Pain Consultants

Scottsdale, Arizona, 85254, United States

Location

East Valley Hematology and Oncology Medical Group

Burbank, California, 91505, United States

Location

Coastal Pain Research

Carlsbad, California, 92009, United States

Location

Navajo Road Pain Management Center

El Cajon, California, 92020, United States

Location

California Cancer Associates for Research and Excellence, Inc.

Fresno, California, 93720, United States

Location

California Cancer Associates For Research and Excellence

Fresno, California, 93720, United States

Location

St. Jude Medical Center, Virginia K. Crosson Cancer Center

Fullerton, California, 92801, United States

Location

Interventional Pain Management

Irvine, California, 92618, United States

Location

South Orange County Surgical Medical Group

Laguna Hills, California, 92653, United States

Location

University of Southern California/Norris Cancer Hospital

Los Angeles, California, 90033, United States

Location

Alexander Ford, MD

Los Angeles, California, 90035, United States

Location

Cancer Care Institute

Los Angeles, California, 90036, United States

Location

Pete J. Ruane, MD, Inc.

Los Angeles, California, 90036, United States

Location

Cedars-Sinai Medical Center Samuel Oschin Comprehensive Cancer Institute

Los Angeles, California, 90048, United States

Location

Moores UC San Diego Cancer Center (UCSD)

San Diego, California, 92093, United States

Location

University of California, San Francisco (UCSF), Hellen Diller Family Comprehensive Cancer Center

San Francisco, California, 94115, United States

Location

Pain Institute of Santa Monica

Santa Monica, California, 90404, United States

Location

Randy Scharlach, MD

Woodland Hills, California, 91367, United States

Location

University of Colorado Cancer Center, Anschutz Medical Campus

Aurora, Colorado, 80045, United States

Location

Red Rocks Center for Rehabilitation

Golden, Colorado, 80401, United States

Location

Western Connecticut Health Network, Danbury Hospital

Danbury, Connecticut, 06810, United States

Location

Stamford Hospital, Bennett Cancer Center

Stamford, Connecticut, 06904, United States

Location

Pain Management Associates of CT, PC

Stamford, Connecticut, 06905, United States

Location

Innovative Medical Research of South Florida, Inc.

Aventura, Florida, 33180, United States

Location

Holy Cross Hospital-Michael & Dianne Bienes Comprehensive Cancer Center

Fort Lauderdale, Florida, 33308, United States

Location

Cancer Specialists of North Florida (ICON)

Jacksonville, Florida, 32256, United States

Location

MD Anderson Center-Orlando Health

Orlando, Florida, 32806, United States

Location

Florida Cancer Research Institute (Florida Cancer Care)

Plantation, Florida, 33317, United States

Location

Florida Cancer Care

Plantation, Florida, 33324, United States

Location

H.Lee Moffitt Cancer Center and Research Institute

Tampa, Florida, 33612, United States

Location

Northeast Georgia Cancer Care

Athens, Georgia, 30607, United States

Location

Interventional Spine and Pain Management

Atlanta, Georgia, 30309, United States

Location

Central Georgia Cancer Care

Macon, Georgia, 31201, United States

Location

Cancer Treatment Centers of America

Newnan, Georgia, 30265, United States

Location

Northwestern University Feinberg School of Medicine, Lynn Sage Comprehensive Breast Center

Chicago, Illinois, 60611, United States

Location

Pain Management Institute

Overland Park, Kansas, 66210, United States

Location

Cancer Center of Kansas

Wichita, Kansas, 67214, United States

Location

James Graham Brown Cancer Center, University of Louisville

Louisville, Kentucky, 40202, United States

Location

Mary Bird Perkins Cancer Center

Baton Rouge, Louisiana, 70809, United States

Location

Center of Cancer and Blood Disorders (VEEDA network)

Bethesda, Maryland, 20817, United States

Location

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States

Location

Lahey Clinic Department of Hematology and Oncology

Burlington, Massachusetts, 01805, United States

Location

Physiatry Consultants

Bay City, Michigan, 48796, United States

Location

Michigan Interventional Pain Center

Brownstown, Michigan, 48183, United States

Location

William Beaumont Hospital Cancer Center

Royal Oak, Michigan, 48071, United States

Location

Glenn Saperstein, D.O., LLC

Saginaw, Michigan, 48604, United States

Location

Advanced Physical Medicine

Saint Clair Shores, Michigan, 48080, United States

Location

Fountain Medical Group

New York, New York, 10021, United States

Location

Weill Cornell Medical College

New York, New York, 100665, United States

Location

Upper East Side Pain Medicine, P.C.

New York, New York, 36607, United States

Location

Comprehensive Pain Management

Syosset, New York, 11791, United States

Location

Eastchester Cancer Care Center

The Bronx, New York, 10469, United States

Location

APWI

Williamsville, New York, 14221, United States

Location

Wake Forest Baptist Health

Winston-Salem, North Carolina, 27157, United States

Location

St. Alexius Medical Center, Mid Dakota Clinic, PC

Bismarck, North Dakota, 58501, United States

Location

Akron General Medical Center

Akron, Ohio, 44302, United States

Location

Cancer Treatment Centers of America

Tulsa, Oklahoma, 74133, United States

Location

OHSU Knight Cancer Institute

Portland, Oregon, 97239, United States

Location

Gettysburg Cancer Center

Hillsdale, Pennsylvania, 17325, United States

Location

Conemaugh Memorial Hospital-Memorial Medical Center

Johnstown, Pennsylvania, 15905, United States

Location

J. Fred Stoner, MD

New Castle, Pennsylvania, 16101, United States

Location

University of Pittsburgh Medical Center (UPMC) Cancer Center

Pittsburgh, Pennsylvania, 15232, United States

Location

Progressive Pain Solutions

Wind Gap, Pennsylvania, 18091, United States

Location

Jerrold Rosenberg, MD

Providence, Rhode Island, 02904, United States

Location

The West Clinic Comprehensive Breast Center

Germantown, Tennessee, 38138, United States

Location

The West Clinic

Memphis, Tennessee, 38120, United States

Location

PRIDE

Dallas, Texas, 75235, United States

Location

UT Southwestern Medical Center / Simmons Comprehensive Cancer Center

Dallas, Texas, 75390, United States

Location

Brooke Army Medical Center (now SAMMC)

Fort Sam Houston, Texas, 78234, United States

Location

Baylor College of Medicine

Houston, Texas, 77030, United States

Location

The University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States

Location

University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States

Location

Cancer Care Centers of South Texas

San Antonio, Texas, 78229, United States

Location

Clinical Trials of Texas, Inc

San Antonio, Texas, 78229, United States

Location

Virginia Cancer Specialists

Fairfax, Virginia, 22031, United States

Location

Swedish Cancer Institute Research

Seattle, Washington, 98104, United States

Location

Multicare Health System-Research Institute

Tacoma, Washington, 98405, United States

Location

Medical College of Wisconsin Department of Surgery Froedtert Hospital and Cancer Center

Milwaukee, Wisconsin, 52336, United States

Location

Central Onco Hospital

Plovdiv, 4002, Bulgaria

Location

Serdika

Sofia, 1303, Bulgaria

Location

Tsaritsa Yoanna - ISUL

Sofia, 1527, Bulgaria

Location

Sveta Marina

Varna, 9010, Bulgaria

Location

Complex Oncology Center, Veliko Tarnovo

Veliko Tarnovo, 5000, Bulgaria

Location

Cross Cancer Institute

Edmonton, Alberta, T6G1Z2, Canada

Location

Health Sciences North Cancer Centre

Greater Sudbury, Ontario, P3E 5J1, Canada

Location

Ottawa Hospital Cancer Centre

Ottawa, Ontario, K1H 8L6, Canada

Location

Sunnybrook Research Institute

Toronto, Ontario, M4N 3M5, Canada

Location

Hospital Charles LeMorne

Greenfield Park, Quebec, J4V 2H1, Canada

Location

Masaryk Memorial Cancer Institute, Comprehensive Cancer Care Clinic

Brno, 656 53, Czechia

Location

University Hospital Hradec Kralove, Clinic of Oncology and Radiotherapy

Hradec Králové, 500 05, Czechia

Location

University Hospital Olomouc, Clinic of Oncology

Olomouc, 775 20, Czechia

Location

General University Hospital in Prague, Clinic of Oncology

Prague, 128 08, Czechia

Location

Institut de Cancérologie de l'Ouest Siet Paul Papin

Angers, Cedex 9, 49933, France

Location

Centre Oscar Lambret

Cédex, Lille, 59020, France

Location

Institut de Cancérologie de l'Ouest/René Gauducheau

Saint Herblain, Nantes Cedex, Loire-Atlantique, 44805, France

Location

Centre Antoine Lacassagne

Nice, 06189, France

Location

Charité Campus Mitte Universitaetsmedizin-Berlin Brustzentrum/Studienzentrum

Berlin, 10117, Germany

Location

Brustzentrum Klinikum Bremen-Mitte gGmbH

Bremen, 28177, Germany

Location

Universitätsklinikum Erlangen, Frauenklinik

Erlangen, D-91054, Germany

Location

Kliniken Essen Mitte, Evang. Huyssens Stiftung/Knappschaft GmbH, Klinik für Senologie/Brustzentrum

Essen, D-45136, Germany

Location

Universitätsklinikum Frankfurt, Klinik für Frauenheilkunde und Geburtshilfe

Frankfurt, 60590, Germany

Location

Nationales Centrum für Tumorerkrankungen (NCT), Gynäkologische Onkologie

Heidelberg, 69120, Germany

Location

Universitätsklinikum Schleswig-Holstein, Campus Kiel

Kiel, 24105, Germany

Location

Universität Marburg

Marburg, 35043, Germany

Location

Rotkreuzklinikum München gGmbH, Frauenklinik

München, 80637, Germany

Location

Universitätsklinikum Münster, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe

Münster, 48149, Germany

Location

Klinikum Stuttgart, Krankenhaus Bad Cannstatt, Frauenklinik

Stuttgart, 70374, Germany

Location

Klinikum Mutterhaus der Borromaeerinnen

Trier, 54290, Germany

Location

Gemeinschaftspraxis für Innere Medizin, Haematologie und internistische Onkologie Dr. R Schlag/Dr. Schoettker

Würzburg, D-97080, Germany

Location

Hetenyi Geza Hospital, Department of Oncology

Szolnok, Jász-Nagykun-Szolnok, H-5000, Hungary

Location

Szent Margit Hospital, V. Department of Internal Medicine, Oncology

Budapest, H-1032, Hungary

Location

Semmelweis University, Department of Diagnostic Radiology and Oncotherapy

Budapest, H-1083, Hungary

Location

Petz Aladar County Teaching Hospital, Center for Oncoradiology

Győr, H-9024, Hungary

Location

Kaposi Mor County Teaching Hospital, Center for Clinical Oncology

Kaposvár, 7400, Hungary

Location

Borsod-Abauj-Zemplen County Hospital and University Educational Hospital, Center for Clinical Oncology and Radiology

Miskolc, 3526, Hungary

Location

Rambam Health Care Campus

Haifa, Haifa District, 31096, Israel

Location

Sheba Medical Centre

Tel Hasomer, Ramat Gan, 52621, Israel

Location

Rabin Medical Centre

Petah Tikva, 49100, Israel

Location

Kaplan Medical Centre

Rehovot, 76100, Israel

Location

Provincial Specialist Hospital in Wroclaw, Department of Chemotherapy

Kamienskiego, Wroclaw, 51-124, Poland

Location

Polish Red Cross Marine Hospital, Department of Chemotherapy

Gdynia, 81-519, Poland

Location

Nicolaus Copernicus Memorial Provincial Specialist Hospital in Lodz, Department of Chemotheraphy

Lodz, 93-513, Poland

Location

Greater Poland Cancer Center, Department of Chemotherapy

Poznan, 61-866, Poland

Location

Magodent

Warsaw, 04-125, Poland

Location

Non-Public Health Care Facility MAGODENT

Warsaw, 04-125, Poland

Location

"Gavril Curteanu" Municipal Clinical Hospital

Oradea, Bihor County, 410469, Romania

Location

Medisprof SRL, Department of Medical Oncology

Cluj-Napoca, Cluj, 400058, Romania

Location

Oncology Center "Sf. Nectarie", Department of Medical Oncology

Craiova, Dolj, 200347, Romania

Location

Dr. Constantin Opris County Emergency Hospital, Department of Oncology

Baia Mare, Maramures, 430031, Romania

Location

Filantropia Clinical Hospital, Obstetrics and Gynaecology Department

Bucharest, 011171, Romania

Location

Coltea Clinical Hospital, Oncology Department

Bucharest, 030171, Romania

Location

Bucharest Universtiy Emergency Hosptial, Oncology Department

Bucharest, 050098, Romania

Location

"Prof. Dr. Ion Chiricuta" Institute of Oncology

Cluj-Napoca, 400015, Romania

Location

Iasi Regional Oncology Institute, Department of Medical Oncology

Iași, 700483, Romania

Location

Oncomed SRL, Department of Medical Oncology

Timișoara, 300239, Romania

Location

Oncology Center #2, Department of Healthcare of Krasnodar Territory Administration

Sochi, Krasnodarskiy Kray, 354057, Russia

Location

Republican Oncology Center

Saransk, Respublika Mordoviya, 430032, Russia

Location

Pyatigorsk Oncology Center

Pyatigorsk, Stavropol Kray, 357502, Russia

Location

Republican Clinical Oncoogy Center

Kazan', Tatarstan Republic, 420029, Russia

Location

Arkhangelsk Clinical Oncology Center

Arkhangelsk, 163045, Russia

Location

Regional Oncology Center

Irkutsk, 664035, Russia

Location

Ivanovo Regional Oncology Center

Ivanovo, 153040, Russia

Location

Clinical Oncology Center #1, Department of Healthcare of Krasnodar Territory Administration

Krasnodar, 350040, Russia

Location

Krasnoyarsk Kryzhanovsky Regional Oncology Center

Krasnoyarsk, 660133, Russia

Location

Kursk Regional Clinical Oncology Center

Kursk, 305035, Russia

Location

N.N. Blokhin Russian Cancer Research Center

Moscow, 115478, Russia

Location

N.N. Blokhin Russian Cancer Reserach Center

Moscow, 115478, Russia

Location

Clinical Diagnostics Center

Nizhny Novgorod, 603006, Russia

Location

Nizhny Novgorod Regional Oncology Center

Nizhny Novgorod, 603081, Russia

Location

Orenburg Regional Clinical Oncology Center

Orenburg, 460051, Russia

Location

Orel Oncology Center

Oryol, 302020, Russia

Location

Medical Institution of Ryazan Region

Ryazan, 390011, Russia

Location

Leningrad Regional Oncology Center

Saint Petersburg, 191104, Russia

Location

St. Petersburg Clinical Hospital

Saint Petersburg, 194017, Russia

Location

Mechnikov North-Western State Medical University

Saint Petersburg, 195067, Russia

Location

Petrov Research Institute of Oncology

Saint Petersburg, 197758, Russia

Location

Municipal Clinical Oncology Center

Saint Petersburg, 198255, Russia

Location

Samara Regional Clinical Oncology Center

Samara, 443031, Russia

Location

Tambov Regional Clinical Oncology Center

Tambov, 392013, Russia

Location

Research Institute of Oncology

Tomsk, 634028, Russia

Location

Bashkir State Medical University

Ufa, 450000, Russia

Location

Regional Clinical Oncology Center

Veliky Novgorod, 173016, Russia

Location

Volgograd Regional Oncology Center #3

Volzhskiy, 404130, Russia

Location

Yaroslavl Regional Oncology Center

Yaroslavl, 150054, Russia

Location

Sverdlovsk Regional Oncology Center

Yekaterinburg, 620036, Russia

Location

Clinical Diagnostics Center

Simferopol, Autonomous Republic of Crimea, 95000, Ukraine

Location

Kryvyi Rih Oncology Center/Dnipropetrovsk Regional Council, Department of Chemotherapy

Kryvyi Rih, Dnipropetrovsk Oblast, 50000, Ukraine

Location

Mariupol City Interdistrict Oncology Center, Surgery Department #2

Mariupol, Donetsk Oblast, 87500, Ukraine

Location

Kharkiv Regional Clinical Oncology Center, Day Care Unit

Kharkiv, Kyivskyi District, 61070, Ukraine

Location

Chernivtsi Regional Clinical Oncology Center, Day Care Unit

Chernivtsi, 58013, Ukraine

Location

Dnipropetrovsk City Multispecialty Clinical Hospital #4/Dnipropetrovsk Regional Council, Department of Chemotherapy

Dnipropetrovsk, 49102, Ukraine

Location

Donetsk City Oncology Center

Donetsk, 83087, Ukraine

Location

Donetsk Regional Antitumor Center, Oncosurgery Department #2

Donetsk, 83092, Ukraine

Location

State Institution: S.P. Grigoriev Institute of Medical Radiology Under the Academy of Medical Sciences of Ukraine

Kharkiv, 61024, Ukraine

Location

Public Institution: Kiev Regional Oncology Hospital within Kyiv Regional Council

Kiev, 04107, Ukraine

Location

Kirovohrad Regional Oncology Center, Department of Mammology

Kirovohrad, 25011, Ukraine

Location

Kyiv City Clinical Oncology Center, Department of Chemotherapy

Kyiv, 03115, Ukraine

Location

Lviv State Regional Treatment and Diagnostics Oncology Center, Department of Chemotherapy

Lviv, 79031, Ukraine

Location

Odesa Regional Clinical Hospital, Center for Mastology

Odesa, 65000, Ukraine

Location

Zakarpattia Regional Clinical Oncology Center, Department of Chemotherapy

Uzhhorod, 88014, Ukraine

Location

Vinnytsia Regional Clinical Oncology Center

Vinnytsia, 21029, Ukraine

Location

Public Institution Zaporizhia Regional Clinical Oncology Center within Zaporizhia Regional Council

Zaporizhia, 69040, Ukraine

Location

Macclesfield District General Hospital

Macclesfield, Cheshire, SK10 3BL, United Kingdom

Location

The Christie NHS Foundation Trust

Withington, Manchester, M20 4BX, United Kingdom

Location

James Cook University Hospital

Middlesbrough, Middlesborough, TS4 3BW, United Kingdom

Location

Plymouth Oncology Centre, Derriford Hospital

Plymouth, Plymouth, PL6 8DH, United Kingdom

Location

The Royal Marsden NHS Foundation Trust

Sutton, Surrey, SM2 5PT, United Kingdom

Location

Leeds Teaching Hospitals Trust, St. James University Hospital

Leeds, West Yorkshire, LS9 7TF, United Kingdom

Location

Leicester Royal Infirmary

Leicester, LE1 5WW, United Kingdom

Location

The Royal Marsden NHS Foundation Trust

London, SW3 6JJ, United Kingdom

Location

Academic Unit of Oncology, Nottingham University Hospital-City Campus

Nottingham, NG7 2UH, United Kingdom

Location

Weston Park Hospital

Sheffield, S10 2SJ, United Kingdom

Location

Southampton General Hospital

Southampton, SO16 6YD, United Kingdom

Location

University Hospital of North Staffordshire

Stoke-on-Trent, ST4 6QG, United Kingdom

Location

Related Publications (3)

  • Amin A, Benavides LC, Holmes JP, Gates JD, Carmichael MG, Hueman MT, Mittendorf EA, Storrer CE, Jama YH, Craig D, Stojadinovic A, Ponniah S, Peoples GE. Assessment of immunologic response and recurrence patterns among patients with clinical recurrence after vaccination with a preventive HER2/neu peptide vaccine: from US Military Cancer Institute Clinical Trials Group Study I-01 and I-02. Cancer Immunol Immunother. 2008 Dec;57(12):1817-25. doi: 10.1007/s00262-008-0509-2. Epub 2008 Apr 8.

    PMID: 18392824BACKGROUND
  • Mittendorf EA, Clifton GT, Holmes JP, Clive KS, Patil R, Benavides LC, Gates JD, Sears AK, Stojadinovic A, Ponniah S, Peoples GE. Clinical trial results of the HER-2/neu (E75) vaccine to prevent breast cancer recurrence in high-risk patients: from US Military Cancer Institute Clinical Trials Group Study I-01 and I-02. Cancer. 2012 May 15;118(10):2594-602. doi: 10.1002/cncr.26574. Epub 2011 Oct 11.

    PMID: 21989902BACKGROUND
  • Mittendorf EA, Lu B, Melisko M, Price Hiller J, Bondarenko I, Brunt AM, Sergii G, Petrakova K, Peoples GE. Efficacy and Safety Analysis of Nelipepimut-S Vaccine to Prevent Breast Cancer Recurrence: A Randomized, Multicenter, Phase III Clinical Trial. Clin Cancer Res. 2019 Jul 15;25(14):4248-4254. doi: 10.1158/1078-0432.CCR-18-2867. Epub 2019 Apr 29.

Related Links

MeSH Terms

Conditions

Breast Neoplasms

Interventions

HER2 peptide (369-377)sargramostimGranulocyte-Macrophage Colony-Stimulating FactorWaterInjections

Condition Hierarchy (Ancestors)

Neoplasms by SiteNeoplasmsBreast DiseasesSkin DiseasesSkin and Connective Tissue Diseases

Intervention Hierarchy (Ancestors)

Colony-Stimulating FactorsGlycoproteinsGlycoconjugatesCarbohydratesHematopoietic Cell Growth FactorsCytokinesIntercellular Signaling Peptides and ProteinsPeptidesAmino Acids, Peptides, and ProteinsProteinsBiological FactorsHydroxidesAlkaliesInorganic ChemicalsAnionsIonsElectrolytesOxidesOxygen CompoundsDrug Administration RoutesDrug TherapyTherapeutics

Study Officials

  • Elizabeth A Mittendorf, MD,FACS

    M.D. Anderson Cancer Center

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 20, 2011

First Posted

November 24, 2011

Study Start

November 1, 2011

Primary Completion

September 21, 2016

Study Completion

September 21, 2016

Last Updated

February 27, 2017

Record last verified: 2017-02

Locations