Risk Factors for Residual Neoplasia After Endoscopic Mucosal Resection
Risk Factors for Local Residual Neoplasia After Convetional Endoscopic Mucosal Resection of Laterally Spreading Tumors
1 other identifier
observational
127
1 country
1
Brief Summary
Laterally Spreading Tumors (LST) are important precursosrs of invasive colorectal cancer. Endoscopic treatment has replaced surgery in most of the cases. Nevertheless, after conventional Endoscopic Mucosal Resection (CER), Local Residual Neoplasia (LRN) is an issue. Therefore, endoscopic follow-up and treatment are necessary. To decrease its occurrence, the risk factors of LRN shoudl be identified. Thereafter, in high-risk patients, other modalities of initial treatment including Endoscopic Submucosal Dissection (ESD) and surgical treatment, could be considered. The purpose of this prospective study is to identify risk factors associated with the presence of LRN after CER of LSTs.
Trial Health
Trial Health Score
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participants targeted
Target at P50-P75 for all trials
Started Jan 2010
1 active site
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Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2011
CompletedFirst Submitted
Initial submission to the registry
November 21, 2011
CompletedFirst Posted
Study publicly available on registry
November 23, 2011
CompletedSeptember 20, 2013
September 1, 2013
11 months
November 21, 2011
September 19, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Occurence of Local Residual Neoplasia (LRN)
LRN was defined as a histologically confirmed neoplastic tissue in the biopsy samples obtained from post-resection scar during follow-up colonoscopy 3 months after endoscopic resection
3 months
Secondary Outcomes (1)
Evaluation of Selected Risk Factors for Local Residual Neoplasia (LRN)
3 months
Eligibility Criteria
Patients referred for Endoscopic Mucosal Resection (EMR) of Laterally Spreading Tumors (LST.)
You may qualify if:
- all consecutive patients referred for EMR of LST
You may not qualify if:
- polyposis syndromes
- previous therapeutic attempt
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Vitkovice Hospital
Ostrava, 703 84, Czechia
Related Publications (1)
Urban O, Kijonkova B, Kajzrlikova IM, Vitek P, Kliment M, Fojtik P, Falt P, Reiterova K, Horava V Jr. Local residual neoplasia after endoscopic treatment of laterally spreading tumors during 15 months of follow-up. Eur J Gastroenterol Hepatol. 2013 Jun;25(6):733-8. doi: 10.1097/MEG.0b013e32835eda96.
PMID: 23442418BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Investigator
Study Record Dates
First Submitted
November 21, 2011
First Posted
November 23, 2011
Study Start
January 1, 2010
Primary Completion
December 1, 2010
Study Completion
November 1, 2011
Last Updated
September 20, 2013
Record last verified: 2013-09