Perception and Multisensory Integration in Neurological Patients Using fMRI

NCT01469858 | Unknown

• 1 other identifier: 044811HMO
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The main objective of the study is to explore and map brain areas involved in sensory perception and multisensory integration in patients with central or peripheral neurological damage. The investigators hypothesize for example, that a change (compare to healthy subjects) in the perceptual maps and body representation could be detected and characterize in patients suffering from impairments of peripheral nerve conduction.

Conditions

Acute Inflammatory Demyelinating Polyradiculoneuropathy; Myasthenia Gravis; Stroke; Anosognosia; Asomatognosia

Outcome Measures

Primary Outcomes (1)

• assessing hemodynamic responses by measurement of the Blood-oxygen-level dependence(BOLD)signal

  Distinct maps of sensory and multisensory representations related to certain disorders will be assed by measurement of the Blood-oxygen-level dependence(BOLD)signal.

  1 year

Study Arms (1)

study group

EXPERIMENTAL

fMRI

Device: Siemens magnetom avanto1.5 Tesla, Siemens magnetom trio A Tim system 3 Tesla

Interventions

Siemens magnetom avanto1.5 Tesla, Siemens magnetom trio A Tim system 3 Tesla DEVICE

functional magnetic resonance imaging

study group

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• diagnosis of the investigated neuronal disease

You may not qualify if:

• contraindication for MRI scan
• pregnancy
• refusal to participate in the study

Sponsors & Collaborators

• Hadassah Medical Organization: lead

Study Sites (1)

Hadassah Medical Organization

Jerusalem, Israel

Location

Related Publications (1)

• Arzy S, Overney LS, Landis T, Blanke O. Neural mechanisms of embodiment: asomatognosia due to premotor cortex damage. Arch Neurol. 2006 Jul;63(7):1022-5. doi: 10.1001/archneur.63.7.1022.

  PMID: 16831974 BACKGROUND

MeSH Terms

Conditions

Guillain-Barre Syndrome; Myasthenia Gravis; Stroke; Agnosia

Condition Hierarchy (Ancestors)

Polyradiculoneuropathy; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Polyneuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases; Autoimmune Diseases; Immune System Diseases; Post-Infectious Disorders; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Paraneoplastic Syndromes, Nervous System; Nervous System Neoplasms; Neoplasms by Site; Neoplasms; Paraneoplastic Syndromes; Neurodegenerative Diseases; Neuromuscular Junction Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Signs and Symptoms

Central Study Contacts

Shahar Arzi, MD PhD

CONTACT

97226777741; shahar.arzy@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 1, 2011
• First Posted: November 10, 2011
• Study Start: November 1, 2011
• Primary Completion: November 1, 2013
• Study Completion: November 1, 2015
• Last Updated: November 10, 2011

Record last verified: 2011-09

Locations

IL (1)