Processing Integration in Neurological Patients Using fMRI

NCT02722070 | Unknown

• 1 other identifier: 0657-15-HMO-CTIL
• Study Type: observational
• Target: 150
• Locations: 0 countries
• Sites: N/A

Brief Summary

The main objective of the study is to explore and map brain areas involved in processing and perception in patients suffering from neurological pathologies and condition. The investigators hypothesize for example, that a change (compare to healthy subjects) in the perceptual maps and body representation could be detected and characterize in patients suffering from impairments of peripheral nerve conduction.

Conditions

Acute Inflammatory Demyelinating Polyradiculoneuropathy; Stroke; Anosognosia; Central and Peripheral Neurodegenerative Pathologies; Neuropsychiatric Conditions

Outcome Measures

Primary Outcomes (1)

• Hemodynamic responses by measurement of the Blood-oxygen-level dependence(BOLD) signal

  Distinct maps of sensory and multisensory representations related to certain disorders will be sassed by measurement of the Blood-oxygen-level dependence(BOLD) signal.

  2 years

Study Arms (4)

Healthy Controls

Age matched control for the various clinical groups

Device: 3 Tesla Siemens Skyra MRI scanner

Neurodegenerative patients

Device: 3 Tesla Siemens Skyra MRI scanner

Stroke patients

Device: 3 Tesla Siemens Skyra MRI scanner

Neuropsychiatric patients

Device: 3 Tesla Siemens Skyra MRI scanner

Interventions

3 Tesla Siemens Skyra MRI scanner DEVICE

Standardly used Magnetic resonance imaging (MRI) protocols, including resting state fMRI, task fMRI, T1 weighted imaging

Healthy Controls; Neurodegenerative patients; Neuropsychiatric patients; Stroke patients

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients suffering from central and peripheral neurological pathologies and conditions

You may qualify if:

• diagnosis of the investigated neuronal disease

You may not qualify if:

• contraindication for MRI scan
• pregnancy
• refusal to participate in the study

Sponsors & Collaborators

• Hadassah Medical Organization: lead

Related Publications (1)

• Arzy S, Overney LS, Landis T, Blanke O. Neural mechanisms of embodiment: asomatognosia due to premotor cortex damage. Arch Neurol. 2006 Jul;63(7):1022-5. doi: 10.1001/archneur.63.7.1022.

  PMID: 16831974 RESULT

MeSH Terms

Conditions

Guillain-Barre Syndrome; Stroke; Agnosia

Condition Hierarchy (Ancestors)

Polyradiculoneuropathy; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Polyneuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases; Autoimmune Diseases; Immune System Diseases; Post-Infectious Disorders; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Signs and Symptoms

Central Study Contacts

Shahar Arzy, M.D, Ph.D

CONTACT

97226777741; shahar.arzy@gmail.com

Gregory Founshtein, M.s

CONTACT

972507794574; gregory.founshtein@mail.huji.ac.il

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 23, 2016
• First Posted: March 29, 2016
• Study Start: March 1, 2016
• Primary Completion: March 1, 2020
• Study Completion: March 1, 2025
• Last Updated: March 29, 2016

Record last verified: 2016-01

Data Sharing

• IPD Sharing: Will not share