Gulf Acute Heart Failure Registry

NCT01467973 | Completed DMC

• 1 other identifier: GHA4
• Study Type: observational
• Target: 5,005
• Locations: 1 country
• Sites: 1

Brief Summary

The Gulf Heart Association (GHA) sponsored Gulf acute heart failure registry (Gulf CARE)is a multinational , multicentre, prospective, observational, hospital-based registry of patients with acute heart failure(AHF) with 3 month and one year follow-up. Study Hypothesis: Due to variations in age at presentation, risk factors for heart failure particularly high prevalence of rheumatic heart disease in certain Gulf countries, variable medical practices and heart failure management setup in the Gulf region, AHF patients in the Gulf states are expected to have different presentation and receive different management than patients in European countries resulting in different outcome. It is also hypothesized that there is considerable gap between heart failure management guidelines and clinical practices in the Gulf region.

Conditions

Acute Heart Failure

Keywords

Heart Failure; Heart Failure, Diastolic; Heart Failure, Systolic; Middle-East

Outcome Measures

Primary Outcomes (1)

• Study of acute heart failure in the Middle-East

  To describe the epidemiology, etiology, precipitating factors, demographics, clinical characteristics, management and outcome of patients admitted with acute heart failure in the Middle-East.

  One year

Secondary Outcomes (1)

• To identify targets for the long term objectives of improving quality of care in acute heart failure patients from the Middle-East

  One year

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients admitted to various hospitals in the Middle-East with acute heart failure.

You may qualify if:

• Clinical diagnosis of acute heart failure
• Admitted to the participating hospitals

You may not qualify if:

• Patients with acute heart failure who are discharged from the emergency room without admission.
• Patients transferred from non-registry hospital
• Failure to obtain informed consent

Sponsors & Collaborators

• Gulf Heart Association: lead
• Servier: collaborator

Study Sites (1)

Royal Hospital

Muscat, Muḩāfaz̧at Masqaţ, 111, Oman

Location

Related Publications (5)

• Jan RK, Alsheikh-Ali A, Mulla AA, Sulaiman K, Panduranga P, Al-Mahmeed W, Bazargani N, Al-Suwaidi J, Al-Jarallah M, Al-Motarreb A, Salam A, Al-Zakwani I. Outcomes of guideline-based medical therapy in patients with acute heart failure and reduced left ventricular ejection fraction: Observations from the Gulf acute heart failure registry (Gulf CARE). Medicine (Baltimore). 2022 Jun 10;101(23):e29452. doi: 10.1097/MD.0000000000029452.

  PMID: 35687781 DERIVED

• Doi SA, Islam N, Sulaiman K, Alsheikh-Ali AA, Singh R, Al-Qahtani A, Asaad N, AlHabib KF, Al-Zakwani I, Al-Jarallah M, AlMahmeed W, Bulbanat B, Bazargani N, Amin H, Al-Motarreb A, AlFaleh H, Panduranga P, Shehab A, Al Suwaidi J, Salam AM. Demystifying Smoker's Paradox: A Propensity Score-Weighted Analysis in Patients Hospitalized With Acute Heart Failure. J Am Heart Assoc. 2019 Dec 3;8(23):e013056. doi: 10.1161/JAHA.119.013056. Epub 2019 Nov 29.

  PMID: 31779564 DERIVED

• Al-Zakwani I, Sulaiman K, Al-Lawati JA, Alsheikh-Ali AA, Panduranga P, Al-Habib KF, Al Suwaidi J, Al-Mahmeed W, Al-Faleh H, Elasfar A, Al-Motarreb A, Ridha M, Bulbanat B, Al-Jarallah M, Bazargani N, Asaad N, Amin H. Impact of Angiotensin Converting Enzyme Inhibitors/Angiotensin Receptors Blockers on Mortality in Acute Heart Failure Patients with Left Ventricular Systolic Dysfunction in the Middle East: Observations from the Gulf Acute Heart Failure Registry (Gulf CARE). Curr Vasc Pharmacol. 2018;16(6):596-602. doi: 10.2174/1570161115666170817164420.

  PMID: 28820057 DERIVED

• Abi Khalil C, Sulaiman K, Mahfoud Z, Singh R, Asaad N, AlHabib KF, Alsheikh-Ali A, Al-Jarallah M, Bulbanat B, AlMahmeed W, Ridha M, Bazargani N, Amin H, Al-Motarreb A, Faleh HA, Elasfar A, Panduranga P, Suwaidi JA; GULF-CARE group. Non-withdrawal of beta blockers in acute decompensated chronic and de novo heart failure with reduced ejection fraction in a prospective multicentre study of patients with acute heart failure in the Middle East. BMJ Open. 2017 Jul 9;7(7):e014915. doi: 10.1136/bmjopen-2016-014915.

  PMID: 28694343 DERIVED

• Khafaji HA, Sulaiman K, Singh R, AlHabib KF, Asaad N, Alsheikh-Ali A, Al-Jarallah M, Bulbanat B, AlMahmeed W, Ridha M, Bazargani N, Amin H, Al-Motarreb A, AlFaleh H, Elasfar A, Panduranga P, Al Suwaidi J. Clinical characteristics, precipitating factors, management and outcome of patients with prior stroke hospitalised with heart failure: an observational report from the Middle East. BMJ Open. 2015 Apr 23;5(4):e007148. doi: 10.1136/bmjopen-2014-007148.

  PMID: 25908674 DERIVED

MeSH Terms

Conditions

Heart Failure; Heart Failure, Diastolic; Heart Failure, Systolic

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Officials

• Kadhim J Sulaiman, FRCPI

  Royal Hospital, Muscat, Oman

  PRINCIPAL INVESTIGATOR

• Prashanth Panduranga, FRCP(Edin)

  Royal Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 7, 2011
• First Posted: November 9, 2011
• Study Start: February 1, 2012
• Primary Completion: November 1, 2012
• Study Completion: November 1, 2013
• Last Updated: April 22, 2014

Record last verified: 2014-04

Locations

OM (1)