NCT01451476

Brief Summary

Skin aging is a complex process involving genetic and environmental factors. The investigators hope to learn more about how human genes and their function can contribute to skin aging and human health.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
122

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started May 2010

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2010

Completed
1.4 years until next milestone

First Submitted

Initial submission to the registry

October 11, 2011

Completed
2 days until next milestone

First Posted

Study publicly available on registry

October 13, 2011

Completed
3.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2015

Completed
8 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2015

Completed
Last Updated

February 9, 2024

Status Verified

February 1, 2024

Enrollment Period

4.9 years

First QC Date

October 11, 2011

Last Update Submit

February 7, 2024

Conditions

Ageing

Keywords

Ageing

Outcome Measures

Primary Outcomes (1)

  • Assessment of age related gene expression changes in skin

    Cross sectional

Study Arms (1)

Healthy females aged >=18

Healthy female volunteers of skin type I or II

Eligibility Criteria

Age18 Years+
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Healthy females age 18 or older

You may qualify if:

  • healthy female, age 18 or older,
  • Fitzpatrick type 1 or 2 skin,
  • able to read and understand written consent form,
  • body mass index normal or overweight range,
  • willing to take blood tests and donate skin samples

You may not qualify if:

  • pregnant or lactating,
  • history of cosmetic surgery affecting the face,
  • use of prescription anti-aging medications for 2 weeks prior to study,
  • use of dietary supplements for 2 weeks prior to study, use of tanning beds or excessive light exposure (\>2 hours) in the past 2 weeks,
  • medical conditions which at the discretion of the investigator will have significant impact on ability to judge subjects' skin characteristics and age, sunless tanner use in past 2 weeks

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Stanford Dermatology

Redwood City, California, 94603, United States

Location

Related Publications (1)

  • Xu J, Spitale RC, Guan L, Flynn RA, Torre EA, Li R, Raber I, Qu K, Kern D, Knaggs HE, Chang HY, Chang AL. Novel Gene Expression Profile of Women with Intrinsic Skin Youthfulness by Whole Transcriptome Sequencing. PLoS One. 2016 Nov 9;11(11):e0165913. doi: 10.1371/journal.pone.0165913. eCollection 2016.

    PMID: 27829007RESULT

Biospecimen

Retention: SAMPLES WITH DNA

Blood and skin samples

Study Officials

  • Alfred Lane, MD

    Stanford University

    PRINCIPAL INVESTIGATOR

  • Anne Chang, MD

    Stanford University

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
instructor

Study Record Dates

First Submitted

October 11, 2011

First Posted

October 13, 2011

Study Start

May 1, 2010

Primary Completion

April 1, 2015

Study Completion

December 1, 2015

Last Updated

February 9, 2024

Record last verified: 2024-02

Locations

US(1)