Provitamin A Absorption and Conversion With Avocados

NCT01432210 | Completed

• 2 other identifiers: 2011H015960030575
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

Vitamin A is necessary in the human diet. The form of vitamin A found in fruits and vegetables is not "active" and must be converted to the active form in the human body. However, information on the ability of humans to absorb and convert vitamin A to the active form is still lacking. In this study, the investigators will observe the absorption and conversion of vitamin A from orange tomato sauce and/or carrots after a meal with fat (from avocado fruit) and a meal without fat. The investigators will also test whether eating these foods might protect the blood against damage that could lead to heart disease.

Conditions

Healthy

Keywords

post-prandial absorption; provitamin A carotenoids; vitamin A; avocado; tomato; carrot

Outcome Measures

Primary Outcomes (1)

• Post-prandial levels of provitamin A and vitamin A

  The absorption of and conversion of provitamin A carotenoids into vitamin A will be measured after the consumption of a carotenoid-rich meal. The meal will be served both with and without avocado as a source of lipid.

  Nine post-prandial blood samples will be taken over twelve hours

Secondary Outcomes (1)

• post-prandial antioxidant status of blood

  comparing baseline vs. 5 hour status

Study Arms (2)

Tomato Meal

OTHER

A tomato meal will be fed with and without avocado.

Other: Post-prandial Feeding Study

Carrot Meal

OTHER

A carrot meal will be fed with and without avocado.

Other: Post-prandial Feeding Study

Interventions

Post-prandial Feeding Study OTHER

Carrot Meal; Tomato Meal

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Total cholesterol (140 to 200 mg/dL)
• BMI 17 to 30
• Age 18-70 years

You may not qualify if:

• Lactating, pregnant, or plan to be pregnant during study
• Tobacco use (cigarettes or chewing tobacco)
• Metabolic disease
• Malabsorption disorders
• History of cancer, esophageal, gastric, or intestinal ulcers
• History of liver or kidney insufficiency or failure
• Allergies to tomatoes or tomato products
• Allergies to carrots
• Allergies to avocados
• Obesity (BMI\>30)
• Hypercholesterolemia (total cholesterol\> 200mg/dL)

Sponsors & Collaborators

• Ohio State University: lead
• Hass Avocado Board: collaborator

Study Sites (1)

The Ohio State University Clinical Research Center

Columbus, Ohio, 43210, United States

Location

Related Publications (2)

• Cooperstone JL, Goetz HJ, Riedl KM, Harrison EH, Schwartz SJ, Kopec RE. Relative contribution of alpha-carotene to postprandial vitamin A concentrations in healthy humans after carrot consumption. Am J Clin Nutr. 2017 Jul;106(1):59-66. doi: 10.3945/ajcn.116.150821. Epub 2017 May 17.

  PMID: 28515067 DERIVED

• Kopec RE, Cooperstone JL, Schweiggert RM, Young GS, Harrison EH, Francis DM, Clinton SK, Schwartz SJ. Avocado consumption enhances human postprandial provitamin A absorption and conversion from a novel high-beta-carotene tomato sauce and from carrots. J Nutr. 2014 Aug;144(8):1158-66. doi: 10.3945/jn.113.187674. Epub 2014 Jun 4.

  PMID: 24899156 DERIVED

Study Officials

• Steven J Schwartz, Ph.D.

  Ohio State University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Scientist

Study Record Dates

• First Submitted: September 4, 2011
• First Posted: September 12, 2011
• Study Start: September 1, 2011
• Primary Completion: January 1, 2012
• Study Completion: March 1, 2012
• Last Updated: September 30, 2016

Record last verified: 2016-09

Locations

US (1)