Optimization of fMRI for the Study of Basal Ganglia Activation in Parkinson's Disease
2010-A01115-34
2 other identifiers
interventional
19
1 country
1
Brief Summary
Functional magnetic resonance imaging (fMRI) is a non-invasive imaging technique assessing neuronal activations during motor or cognitive tasks. The MRI sequences used are currently optimized for the study of cortex activations, particularly concerning the echo time (TE).Very few studies are interested in optimizing the fMRI for the study of the basal ganglia, structure implicated in many neurological diseases such as Parkinson's disease. The T2 \* is a tissue parameter dependent of iron content, which differs with brain structures and probably also with age and in case of neurodegenerative disease. Optimal TE s should correspond to the T2 \* of studied brain structure The primary purpose is to optimize the fMRI by a quantitative measurement of the T2\* in the cortex and the basal ganglia using MRI. The secondary purpose is to study the effect of age and Parkinson's disease on T2\*.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Feb 2011
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2011
CompletedFirst Submitted
Initial submission to the registry
July 7, 2011
CompletedFirst Posted
Study publicly available on registry
September 7, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2011
CompletedJune 17, 2016
June 1, 2016
10 months
July 7, 2011
June 16, 2016
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
The quantitative measurement of T2* in the cortex and basal ganglia using MRI, made à J0.
at day 1
Interventions
The primary purpose is to optimize the fMRI by a quantitative measurement of the T2\* in the cortex and the basal ganglia using MRI. The secondary purpose is to study the effect of age and Parkinson's disease on T2\*.
Eligibility Criteria
You may qualify if:
- For patients :
- Patients with idiopathic Parkinson's disease according to UKPDSBB criterias
- Men or women aged between 40 to 80 years
- not treated with deep brain stimulation
- For healthy subjects
- \- Men or women aged between 40 to 80 years
You may not qualify if:
- For patients
- Dementia (MMS\<24)
- Contraindication to MRI.
- Under guardianship
- In excluding period for another study
- For healthy subjects
- Antecedent of neurodegenerative diseases or psychiatric diseases
- Contraindication to MRI
- Under guardianship
- In excluding period for another study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Chu Clermont-Ferrand
Clermont-Ferrand, France
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Miguel ULLA
University Hospital, Clermont-Ferrand
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 7, 2011
First Posted
September 7, 2011
Study Start
February 1, 2011
Primary Completion
December 1, 2011
Study Completion
December 1, 2011
Last Updated
June 17, 2016
Record last verified: 2016-06