Facial Expression Recognition of Emotion and Categorization of Emotional Words in Parkinson's Disease. Impact of L-Dopa and Deep Brain Stimulation of Subthalamic Nucleus

NCT00664157 | Completed

• 2 other identifiers: CHU-0033RBHP 2007 Durif
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Parkinson'disease is a neurodegenerative disorder characterised by bradykinesia, rigidity, rest tremor and postural instability. Dopaminergic therapy such as L-Dopa and dopamine agonists usually leads to a dramatic improvement of symptoms, but disease progression nevertheless remains inevitable. Bilateral Deep brain stimulation in subthalamic nucleus is now considered the gold standard surgical treatment. Parkinson'disease mainly affects the nigrostriatal dopaminergic system which is linked to the limbic system and could be responsible of a specific trouble in the recognition in some facial expression. We hypothesise that patients with Parkinson'disease present a dysfunction of voluntary and automatic treatment of emotional information. The main purpose of this study is to show if patients with Parkinson'disease present a lack of specific facial expression recognition of emotion and determinate more precisely if this alteration involves the cortical way (high frequency way) or the under cortical way (low frequency way). We also examine the role of L-Dopa and the deep brain stimulation on emotion perception

Conditions

Idiopathic Parkinson's Disease

Keywords

Idiopathic Parkinson's disease; L-Dopa; Deep Brain stimulation; Facial expression recognition of emotion; Frequency levels; Automatic and voluntary information treatment; Patient with an Idiopathic Parkinson's disease

Outcome Measures

Primary Outcomes (1)

• Facial expression recognition test

  % of exact responses

Secondary Outcomes (1)

• Lexical decision test

  The time to respond

Study Arms (1)

2

OTHER

40 patients with an idiopathic Parkinson's disease and 40 healthy paired volunteers (control group)

Behavioral: Facial expression recognition of emotion

Interventions

Facial expression recognition of emotion BEHAVIORAL

Facial expression recognition test Lexical decisiontest

2

Eligibility Criteria

• Age: 30 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age : 30-75 years
• Patient with an idiopathic Parkinson's disease according to the criteria of the "Parkinson's Disease Society Brain Bank" (Hughes et al., 1992)
• Patient treated with a deep brain stimulation according to the French consensus conference of treatment of Parkinson's disease (Consensus Conference Proceeding, 2000)
• Effect of the stimulation 50%
• Affiliation to social security
• Agreement of patients

You may not qualify if:

• Patients suffering of an atypical Parkinson syndrome
• Patients with severe tremor before surgery
• Patients with a vision contrast altered.
• Patients who do not understand the words associated with an emotion
• Pregnant women
• Person who participate to an other study

Sponsors & Collaborators

• University Hospital, Clermont-Ferrand: lead

Study Sites (1)

CHU

Clermont-Ferrand, 63003, France

Location

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Officials

• Franck Durif, PUPH

  University Hospital, Clermont-Ferrand

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: April 21, 2008
• First Posted: April 22, 2008
• Study Start: September 1, 2007
• Primary Completion: October 1, 2008
• Study Completion: October 1, 2009
• Last Updated: January 19, 2011

Record last verified: 2011-01

Locations

FR (1)