Words Generation in Compulsives Gamblers and Parkinson's Disease Patients

NCT01888276 | Completed

• 1 other identifier: 11 225 02
• Study Type: interventional
• Target: 37
• Locations: 1 country
• Sites: 1

Brief Summary

The pathophysiology of compulsive disorders as gambling could be close to behavior problems encountered in Parkinson's disease associated with a hyperactivity of the motivational system. Thanks to the words generation test, which reflects the cortico-subcortical loop functioning, involved in motivation, we want to evaluate and compare using tools (words generation and behavioral tests) the motivational functioning of gamblers and healthy volunteers that we can then compare to that of Parkinson's patients with and without behavioral hyperdopaminergic disorders which were explored in another study.

Conditions

Parkinson Disease

Keywords

Words generation, compulsive gamblers

Outcome Measures

Primary Outcomes (1)

• Changement of number of mistake during the words generation test

  one hour

Secondary Outcomes (1)

• changement of number of uncorrected errors during the Stroop test which reflects the incapacity to inhibit the reading and that evaluates attention

  one hour

Study Arms (2)

healthy volunteers

OTHER

evaluation of word generation and of motivation

Other: evaluation of word generation and of motivation

compulsive gamblers

OTHER

evaluation of word generation and of motivation

Other: evaluation of word generation and of motivation

Interventions

evaluation of word generation and of motivation OTHER

Each subject will realize twice each test during 2 sessions with one hour in between : During the session 1 : * The test of words generation, which is to produce action verbs in response to 40 nouns, and noun in response to verbs. * The test of Stroop that assesses selective attention During the session 2: * The test of words generation, which is to produce action verbs in response to 40 nouns, and noun in response to verbs. * The task of the casino (Iowa Gambling Test) * The task of landing * The test of Stroop

compulsive gamblers; healthy volunteers

Eligibility Criteria

• Age: 30 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• For healthy volunteers :
• Subject from 30 to 75 years old (Male and female)
• Subject with French mother tongue
• Subject who give their informed and signed consent.
• Subject affiliated to a social protection program
• For compulsive gamblers :
• Subject from 30 to 75 years old (Male and female)
• Subject with French mother tongue
• Subject with at least 5 criteria of 10 DSM IV diagnostic criteria for pathological gambling
• Subject who give their informed and signed consent.
• Subject affiliated to a social protection program

You may not qualify if:

• For healthy volunteers and compulsive gamblers :
• Presence of apathy defined as a score greater or equal to 14 on the scale of Starkstein
• Presence of severe depression defined as a score greater or equal to 25 on the scale BDI (Beck Depression Inventory)
• Presence of dementia defined as a score below 25 on the MMSE
• Subject with vision problems making it impossible for the tests
• Pregnant women
• Subject under tutelage, curatelle or law protection
• Subject included in an other clinical study

Sponsors & Collaborators

• University Hospital, Toulouse: lead

Study Sites (1)

CHU toulouse

Toulouse, 31000, France

Location

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Officials

• Christine Brefel, MD

  UH Toulouse

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 20, 2012
• First Posted: June 27, 2013
• Study Start: February 1, 2012
• Primary Completion: April 1, 2014
• Study Completion: April 1, 2014
• Last Updated: June 11, 2015

Record last verified: 2015-06

Locations

FR (1)