Alzheimer's Disease Core Center

NCT01421420 | Unknown

• 1 other identifier: P30AG019610
• Study Type: observational
• Target: 900
• Locations: 1 country
• Sites: 1

Brief Summary

The main objective of this research project is to provide a comprehensive clinical database of patients with Alzheimer's disease (AD) and other forms of dementia, individuals with mild cognitive impairment (MCI), and age-matched normal controls. The study will also attempt to identify cognitively normal individuals at genetically defined risk for Alzheimer's disease through genetic screening. All participants are seen annually. Autopsies to establish diagnoses in patients with dementia, patients with mild MCI, and cognitively normal elderly control subjects will also be conducted.

Conditions

Alzheimer's Disease; Mild Cognitive Impairment; Age-Related Memory Disorders

Keywords

Alzheimer's; Dementia; Mild Cognitive Impairment

Outcome Measures

Primary Outcomes (1)

• Neuropsychological Test Scores

  Cognitive function will be evaluated on a yearly basis using a battery of neuropsychological tests, which will then be scored and normed according to established guidelines.

  Up to 20 years

Secondary Outcomes (2)

• Neurological Exam

  Up to 20 Years

• Brain Tissue

  From date of entry until date of death assessed up to 20 years

Study Arms (4)

Alzheimer's Disease

Mild Cognitive Impairment

Other forms of Dementia, not AD

Normal Elderly Individuals

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Individuals with Alzheimer's disease, mild cognitive impairment, other forms of dementia, and normal elderly individuals.

You may qualify if:

• For patients with MCI, or dementia, the presence of cognitive deficits including memory, language, and executive function.

You may not qualify if:

• Presence of non-neurological medical conditions interfering with cognition.

Sponsors & Collaborators

• University of Arizona: lead
• Banner Health: collaborator
• Barrow Neurological Foundation: collaborator
• Mayo Clinic: collaborator
• National Institute on Aging (NIA): collaborator
• National Institutes of Health (NIH): collaborator

Study Sites (1)

University of Arizona, University Medical Center

Tucson, Arizona, 85724, United States

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

blood, saliva, brain tissue

MeSH Terms

Conditions

Alzheimer Disease; Cognitive Dysfunction; Memory Disorders; Dementia

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders; Cognition Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Steven Z Rapcsak, M.D.

  University of Arizona

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 25, 2011
• First Posted: August 22, 2011
• Study Start: July 1, 2001
• Primary Completion: December 1, 2024
• Study Completion: July 1, 2025
• Last Updated: June 12, 2015

Record last verified: 2015-01

Locations

US (1)