Nutrient Synergy in Beef and Stimulation of Protein Synthesis in Elderly
1 other identifier
interventional
20
1 country
1
Brief Summary
This study will compare the effects of cooked, ground beef to those of beef protein isolate on blood and muscle proteins.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable healthy
Started Jul 2011
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2011
CompletedFirst Submitted
Initial submission to the registry
August 10, 2011
CompletedFirst Posted
Study publicly available on registry
August 12, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2012
CompletedJanuary 18, 2012
January 1, 2012
2 months
August 10, 2011
January 17, 2012
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
skeletal muscle synthetic and breakdown rate
Using stable isotope infusion/ingestion methodology, we will measure plasma and skeletal muscle metabolic rate. Our primary end points will be muscle protein fractional synthesis rate (FSR) and whole body protein turnover rate.
day one
Secondary Outcomes (1)
concentrations of plasma amino acids, insulin and glucose
day one
Study Arms (2)
3 ounces of cooked, 85% lean ground beef
EXPERIMENTALSubjects would consume 3 ounces of cooked, 85% lean ground beef at one setting on one day.
20 grams of Beef protein isolate
EXPERIMENTALSubjects would consume 20 grams of beef protein isolate dissolved into 200mL water at one setting on one day.
Interventions
Consumed once per subject.
Subjects would drink 200 ml water mixed with 20 grams of beef protein isolate one time.
Eligibility Criteria
You may qualify if:
- Healthy male or female.
- Age 60 years or older.
You may not qualify if:
- Any (history of) gastrointestinal disease that interferes with GI function
- Diagnosed and active treatment of Diabetes Mellitus type I or II
- History of congestive heart failure
- Recent (6 months) hospitalization for heart disease treatment or management (e.g. PTCA, stent, surgery)
- Myocardial infarction in the past year
- Infection or fever in the 7 days prior to enrollment
- Current use of corticosteroids, growth hormone, or testosterone
- Adherence to a weight loss diet
- Use of protein-containing or amino acid-containing nutritional supplements within one week of enrollment
- Current alcohol (\>7 ETOH per week) or drug abuse
- Platelet count (PLT) \< 100,000
- History of hypo- or hyper-coagulation disorders including use of a coumadin derivative
- Currently taking anti-thrombotics and cannot stop for 7 days (i.e. medical indication)
- Allergy to local anesthetic
- Blood hemoglobin \< 9.0 g/dL
- +1 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
UAMS Center on Aging
Little Rock, Arkansas, 72205, United States
Study Officials
- PRINCIPAL INVESTIGATOR
Robert R Wolfe, PhD
UAMS
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 10, 2011
First Posted
August 12, 2011
Study Start
July 1, 2011
Primary Completion
September 1, 2011
Study Completion
January 1, 2012
Last Updated
January 18, 2012
Record last verified: 2012-01