Sponsor study identifier
Secondary identifiers
OTHER_GRANT · University Hospital Rostock
interventional
140
1 country
1
Study Start
February 2002
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
October 2010
Actual (reported)Study Completion
March 2011
Actual (reported)The objective of INSTEAD is to compare long-term (5 years) outcomes of endograft prosthesis versus medical management in patients with dissection of the thoracic aorta.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 2011
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 2002
Date type not reportedThis date has not been verified as actual or estimated.
October 2010
Actual (reported)March 2011
Actual (reported)August 11, 2011
Actual (reported)August 12, 2011
Actual (reported)All cause mortality
5 years post randomization
Aorta-specific mortality
5 years post randomization
Progression of disease
5 years
Aortic remodeling
5 years
Stentgraft
Antihypertensive medication
Thoracic aortic stentgraft
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
University Hospital Rostock; Heart Center
Rostock, Mecklenburg-Vorpommern, 18057, Germany
Nienaber CA, Zannetti S, Barbieri B, Kische S, Schareck W, Rehders TC; INSTEAD study collaborators. INvestigation of STEnt grafts in patients with type B Aortic Dissection: design of the INSTEAD trial--a prospective, multicenter, European randomized trial. Am Heart J. 2005 Apr;149(4):592-9. doi: 10.1016/j.ahj.2004.05.060.
Nienaber CA, Rousseau H, Eggebrecht H, Kische S, Fattori R, Rehders TC, Kundt G, Scheinert D, Czerny M, Kleinfeldt T, Zipfel B, Labrousse L, Ince H; INSTEAD Trial. Randomized comparison of strategies for type B aortic dissection: the INvestigation of STEnt Grafts in Aortic Dissection (INSTEAD) trial. Circulation. 2009 Dec 22;120(25):2519-28. doi: 10.1161/CIRCULATIONAHA.109.886408. Epub 2009 Dec 7.
Christoph A Nienaber, MD
University of Rostock
140 participants (actual enrollment reported by the registry).
First Submitted
August 11, 2011
First Posted
August 12, 2011
Study Start
February 2002
Date type not reportedThis date has not been verified as actual or estimated.
Functional Study of Metabolites in Patients With Aortic Dissection
Contact the study team to confirm eligibility.
Nienaber CA, Kische S, Rousseau H, Eggebrecht H, Rehders TC, Kundt G, Glass A, Scheinert D, Czerny M, Kleinfeldt T, Zipfel B, Labrousse L, Fattori R, Ince H; INSTEAD-XL trial. Endovascular repair of type B aortic dissection: long-term results of the randomized investigation of stent grafts in aortic dissection trial. Circ Cardiovasc Interv. 2013 Aug;6(4):407-16. doi: 10.1161/CIRCINTERVENTIONS.113.000463. Epub 2013 Aug 6.
Primary Completion
October 2010
Actual (reported)Study Completion
March 2011
Actual (reported)Last Updated
August 12, 2011
Record last verified: 2011-03
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Source: ClinicalTrials.gov.
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