Effects of Monosodium Glutamate on Energy Balance and Eating Behavior
Effects of Ingesting Monosodium Glutamate (MSG) on Energy Balance and Eating Behavior Following Moderate Energy Restriction and Weight Loss in Overweight Women
1 other identifier
interventional
44
1 country
1
Brief Summary
This study will test whether regular consumption of Monosodium Glutamate (MSG) immediately prior to each of the three major meals (breakfast, lunch, dinner) inhibits body weight and fat regain following a period of moderate, yet clinically significant weight loss.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable obesity
Started Aug 2011
Typical duration for not_applicable obesity
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2011
CompletedFirst Submitted
Initial submission to the registry
August 3, 2011
CompletedFirst Posted
Study publicly available on registry
August 5, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2014
CompletedMay 21, 2015
August 1, 2014
3 years
August 3, 2011
May 19, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Change in body weight
Subjects will have their body weight measured to determine the effect of MSG on body weight regain following weight loss.
weeks 11, 12, and 25
Secondary Outcomes (3)
Change in body fat
weeks 11 and 25
Change in eating behavior
weeks 11, 12 and 25
Change in resting energy expenditure
weeks 11, 12, and 25
Study Arms (2)
Broth- NaCl
PLACEBO COMPARATORSodium chloride containing broth matched for sodium content to the MSG broth
Broth- MSG
ACTIVE COMPARATORMSG containing broth with the same sodium content as the placebo comparator.
Interventions
Eligibility Criteria
You may qualify if:
- Women
- Age 19-45
- BMI 27-35
- Blood pressure \<140/90
- Non-smoking
You may not qualify if:
- Anemic: hgb \< 11.5 mg/dL
- Sensitivity to MSG (self reported)
- Pregnant or planning to get pregnant
- Taking medication for hypertension, depression, or weight loss
- Diabetic
- Vegetarian
- MRI Contraindications: internal metal, braces on teeth, history of metal in the eye, claustrophobia
- blindness or heavily corrected vision
- not fluent in English
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- USDA, Western Human Nutrition Research Centerlead
- Ajinomoto USA, INC.collaborator
Study Sites (1)
Western Human Nutrition Center, University of California Davis
Davis, California, 95616, United States
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Kevin Laugero, PhD
WHNRC, ARS, University of California Davis
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- FED
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 3, 2011
First Posted
August 5, 2011
Study Start
August 1, 2011
Primary Completion
August 1, 2014
Study Completion
August 1, 2014
Last Updated
May 21, 2015
Record last verified: 2014-08