The Metabolic Effects of Breaks in Sedentary Time

NCT01398059 | Completed Results

• 1 other identifier: 11/01E
• Study Type: interventional
• Target: 19
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine whether acute bouts of sedentary behaviour (with or without breaks and/or structured physical activity) result in measurable changes in metabolic health in children and youth.

Conditions

Feasibility; Insulin; Glucose; Lipids; Eating

Keywords

Sedentary Behavior; Cardiometabolic Risk; Pediatrics

Outcome Measures

Primary Outcomes (1)

• Change in Insulin Net Incremental Area-Under-The-Curve (iAUC)

  Insulin levels will be assessed multiple times throughout the day, and the resulting values will be used to calculate AUC.

  Baseline, 1.5, 3, 4.5, 6, and 7.5 hours

Secondary Outcomes (4)

• Change in Triglyceride Net Incremental Area-Under-The-Curve (iAUC)

  Baseline, 1.5, 3, 4.5, 6, and 7.5 hours

• Change in HDL-Cholesterol (HDL-C) Net Incremental Area-Under-The-Curve (iAUC)

  Baseline, 1.5, 3, 4.5, 6, and 7.5 hours

• Change in LDL-Cholesterol (LDL-C) Net Incremental Area-Under-The-Curve (iAUC)

  Baseline, 1.5, 3, 4.5, 6, and 7.5 hours

• Change in Glucose Net Incremental Area-Under-The-Curve (iAUC)

  Baseline, 1.5, 3, 4.5, 6, and 7.5 hours

Study Arms (3)

Sedentary

EXPERIMENTAL

In this condition, participants will engage in 8 hours of uninterrupted sedentary behaviour.

Other: Sedentary

Sedentary With Breaks

EXPERIMENTAL

In this condition participants will engage in 8 hours of sitting, although the sitting will be interrupted every 20 minutes. During these interruptions participants will spend 2 minutes walking at an intensity equivalent to 30% of VO2peak.

Other: Sedentary With Breaks

Sedentary With Breaks and Physical Activity

EXPERIMENTAL

In this condition participants will engage in 8 hours of sitting, although the sitting will be interrupted every 20 minutes. During these interruptions participants will spend 2 minutes walking at an intensity equivalent to 30% of VO2peak. Participants will also engage in 20 minutes of structured physical activity at an intensity of 60% of VO2peak in both the morning and afternoon.

Other: Sedentary With Breaks and Physical Activity

Interventions

Sedentary OTHER

In this condition, participants will engage in 8 hours of uninterrupted sedentary behaviour.

Sedentary

Sedentary With Breaks OTHER

In this condition participants will engage in 8 hours of sitting, although the sitting will be interrupted every 20 minutes. During these interruptions participants will spend 2 minutes walking at an intensity equivalent to 30% of VO2peak.

Sedentary With Breaks

Sedentary With Breaks and Physical Activity OTHER

In this condition participants will engage in 8 hours of sitting, although the sitting will be interrupted every 20 minutes. During these interruptions participants will spend 2 minutes walking at an intensity equivalent to 30% of VO2peak. Participants will also engage in 20 minutes of structured physical activity at an intensity of 60% of VO2peak in both the morning and afternoon.

Sedentary With Breaks and Physical Activity

Eligibility Criteria

• Age: 10 Years - 14 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Age 10-14
• Normal weight or obese

You may not qualify if:

• Overweight
• Overt diabetes or heart disease (or taking medications to treat this conditions)
• Being unambulatory or otherwise unable to perform the study protocol

Sponsors & Collaborators

• Children's Hospital of Eastern Ontario: lead
• University of Ottawa: collaborator

Study Sites (1)

Behavioural Metabolic Research Unit, University of Ottawa

Ottawa, Ontario, K1N 6N5, Canada

Location

Related Publications (1)

• Saunders TJ, Chaput JP, Goldfield GS, Colley RC, Kenny GP, Doucet E, Tremblay MS. Prolonged sitting and markers of cardiometabolic disease risk in children and youth: a randomized crossover study. Metabolism. 2013 Oct;62(10):1423-8. doi: 10.1016/j.metabol.2013.05.010. Epub 2013 Jun 15.

  PMID: 23773981 RESULT

MeSH Terms

Conditions

Insulin Resistance; Sedentary Behavior

Interventions

Exercise

Condition Hierarchy (Ancestors)

Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Results Point of Contact

• Title: Dr. Travis Saunders
• Organization: University of Prince Edward Island

trsaunders@upei.ca

902-566-0641

Study Officials

• Mark S Tremblay, OhD

  Children's Hospital of Eastern Ontario Research Institute

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr Mark Tremblay, Director, Healthy Active Living and Obesity Research Group

Study Record Dates

• First Submitted: July 18, 2011
• First Posted: July 20, 2011
• Study Start: July 1, 2011
• Primary Completion: August 1, 2012
• Study Completion: August 1, 2012
• Last Updated: July 24, 2019
• Results First Posted: July 24, 2019

Record last verified: 2019-05

Locations

CA (1)