Polymorphisms in the Vitamin D System and Health

NCT01395303 | Completed

• 1 other identifier: UIT-ENDO-2011-2
• Study Type: observational
• Target: 9,700
• Locations: 1 country
• Sites: 1

Brief Summary

Polymorphisms in the vitamin D system appear to affect the serum 25(OH)D levels. If so one would expect these polymorphisms to be associated with vitamin D related conditions and diseases, which will be tested in the present study including DNA analyses in 9700 subjects

Conditions

Infarction; Stroke; Diabetes; Fracture; Aortic Stenosis; Cancer; Death

Keywords

infarction; stroke; diabetes; fracture; aortic stenosis; cancer; death; vitamin D; androgens; thyroid hormones

Study Arms (8)

myocardial infarction

subjects with myocardial infarction in the Tromsø study end point registry

type 2 diabetes

subjects with type 2 diabetes in the Tromsø study end point registry

stroke

subjects with stroke in the Tromsø study end point registry

fracture

subjects with fracture in the Tromsø study end point registry

cancer

subjects with cancer in the Tromsø study end point registry

death

subjects registered as dead in the Tromsø study end point registry

aortic stenosis

subjects with aortic stenosis in the Tromsø study end point registry

control group

randomly selected controls from the Tromsø study

Eligibility Criteria

• Age: 30 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Subjects from the fourth Tromsø study performed in 1994-1995 who had blood samples taken for later DNA analyses

You may qualify if:

• participated in the fourth Tromsø study, later registered in our end point registry or selected as a control subject

You may not qualify if:

• lacking DNA sample

Sponsors & Collaborators

• University of Tromso: lead

Study Sites (1)

University of Tromsø

Tromsø, Tromsø, 9037, Norway

Location

Related Publications (1)

• Jorde R, Schirmer H, Wilsgaard T, Joakimsen RM, Mathiesen EB, Njolstad I, Lochen ML, Figenschau Y, Berg JP, Svartberg J, Grimnes G. Polymorphisms related to the serum 25-hydroxyvitamin D level and risk of myocardial infarction, diabetes, cancer and mortality. The Tromso Study. PLoS One. 2012;7(5):e37295. doi: 10.1371/journal.pone.0037295. Epub 2012 May 23.

  PMID: 22649517 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

DNA from blood clots

MeSH Terms

Conditions

Infarction; Stroke; Diabetes Mellitus; Fractures, Bone; Aortic Valve Stenosis; Neoplasms; Death

Condition Hierarchy (Ancestors)

Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Wounds and Injuries; Aortic Valve Disease; Heart Valve Diseases; Heart Diseases; Ventricular Outflow Obstruction

Study Officials

• Rolf Jorde, Professor

  University of Tromso

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: July 14, 2011
• First Posted: July 15, 2011
• Study Start: April 1, 2011
• Primary Completion: July 1, 2016
• Study Completion: August 1, 2016
• Last Updated: November 11, 2016

Record last verified: 2016-11

Locations

NO (1)