Ventilatory Effect on Speed of Anesthesia Under Various Inhaled Anesthetics

NCT01171833 | Completed DMC

• 1 other identifier: J In 2010-1
• Study Type: interventional
• Target: 36
• Locations: 0 countries
• Sites: N/A

Brief Summary

Three groups of patients are going to have minor surgery under general anesthesia with inhaled anesthetics and different ventilatory setting (Tidal volume: 8, 10, 12 ml/kg, respiratory rate: 10/min each). Group A (Sevoflurane) will use sevoflurane, group B (Desflurane) will use desflurane, and group C (Isoflurane) will use isoflurane. It will be observed differences among the groups for ventilatory effects on speed of induction. Duration of this randomised controlled trial will be about 3 months. Estimated sample size will be 36 patients(12 in each group).

Conditions

Pharmacokinetics of Inhaled Anesthetics

Keywords

Anesthetic induction; Desflurane; Isoflurane; Sevoflurane; Ventilation

Outcome Measures

Primary Outcomes (1)

• End-tidal concentrations of isoflurane, sevoflurane and desflurane, and BIS values with hypo-, normo-, hyperventilation

  The inspiratory, and end-tidal concentrations of volatile anesthetics, partial pressure of end-tidal carbon dioxide will be recorded from an S/5 Avance anesthetic workstation (Datex-Ohmeda) and an embedded monitor. BIS values are measured with a BIS monitor.

  at 0, 30, 60, 90, 120, 180, 240, 300, 360, 480, 600, 720 sec after volatile gas starts

Study Arms (3)

Group A(Sevoflurane)

EXPERIMENTAL

Twelve patients will be enrolled in this group. They will be divided into subgroups with ventilatory settings. Each subgroup has 4 patients. A8: tidal volume(8 ml/kg) and respiratory rate(10 /min) A10: tidal volume(10 ml/kg) and respiratory rate(10 /min) A12: tidal volume(12 ml/kg) and respiratory rate(10 /min)

Drug: Sevoflurane

Group B(Desflurane)

EXPERIMENTAL

Twelve patients will be enrolled in this group. They will be divided into subgroups with ventilatory settings. Each subgroup has 4 patients. A8: tidal volume(8 ml/kg) and respiratory rate(10 /min) A10: tidal volume(10 ml/kg) and respiratory rate(10 /min) A12: tidal volume(12 ml/kg) and respiratory rate(10 /min)

Drug: Desflurane

Group C(Isoflurane)

EXPERIMENTAL

Twelve patients will be enrolled in this group. They will be divided into subgroups with ventilatory settings. Each subgroup has 4 patients. A8: tidal volume(8 ml/kg) and respiratory rate(10 /min) A10: tidal volume(10 ml/kg) and respiratory rate(10 /min) A12: tidal volume(12 ml/kg) and respiratory rate(10 /min)

Drug: Isoflurane

Interventions

Sevoflurane DRUG

2.0 vol% prefilled in a corrugated circuit.

Also known as: Sevorane

Group A(Sevoflurane)

Desflurane DRUG

6.0 vol% prefilled in a corrugated circuit.

Also known as: Suprane

Group B(Desflurane)

Isoflurane DRUG

1.2 vol% prefilled in a corrugated circuit.

Also known as: Aerane

Group C(Isoflurane)

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• ASA PS I, II
• Age: 20-60 years male and female
• Elective schedule with minor surgery
• BMI \< 30

You may not qualify if:

• Patients with pulmonary, cardiac, endocrinal, neuromuscular and neurological diseases or past history
• Upper airway anomaly or deformity
• ASA PS III or higher
• Pregnant women
• BMI \>= 30

Sponsors & Collaborators

• DongGuk University: lead

MeSH Terms

Conditions

Respiratory Aspiration

Interventions

Sevoflurane; Desflurane; Isoflurane

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Methyl Ethers; Ethers; Organic Chemicals; Hydrocarbons, Fluorinated; Hydrocarbons, Halogenated; Hydrocarbons; Ethyl Ethers

Study Officials

• Junyong In, MD

  Dept. of anesthesiology and pain medicine, Dongguk University Ilsan Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor

Study Record Dates

• First Submitted: July 28, 2010
• First Posted: July 29, 2010
• Study Start: June 1, 2010
• Primary Completion: October 1, 2010
• Study Completion: October 1, 2010
• Last Updated: August 13, 2012

Record last verified: 2012-08