NCT06252207

Brief Summary

The investigators thus propose a comparative effectiveness quality improvement project to evaluate the feasibility of switching from near-exclusive use of isoflurane in adult general surgical patients to Desflurane.

Trial Health

30
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Timeline
Completed

Started Dec 2023

Typical duration for not_applicable surgery

Geographic Reach
1 country

1 active site

Status
withdrawn

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 8, 2023

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

January 22, 2024

Completed
18 days until next milestone

First Posted

Study publicly available on registry

February 9, 2024

Completed
2.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 2, 2026

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 2, 2026

Completed
Last Updated

March 5, 2026

Status Verified

August 1, 2025

Enrollment Period

2.2 years

First QC Date

January 22, 2024

Last Update Submit

March 3, 2026

Conditions

Surgery

Outcome Measures

Primary Outcomes (1)

  • Duration of post-anesthesia care unit recovery

    Time from entry to the post-anesthesia to discharge from unit.

    1 hour

Secondary Outcomes (3)

  • Duration of anesthetic emergence

    1 hour

  • Cost of post-anesthesia care unit.

    2 hours

  • Delirium

    5 days

Study Arms (2)

Desflurane

EXPERIMENTAL

General anesthesia with desflurane.

Drug: Desflurane

Isoflurane

EXPERIMENTAL

General anesthesia with isoflurane.

Drug: Isoflurane

Interventions

DesfluraneDRUG

General anesthesia with desflurlane

Desflurane
IsofluraneDRUG

General anesthesia with isoflurane

Isoflurane

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Adults having general anesthesia in the G operating room suite at the Cleveland Clinic Main Campus.

You may not qualify if:

  • Operations lasting \<1.5 hours.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Cleveland Clinic

Cleveland, Ohio, 44195, United States

Location

MeSH Terms

Interventions

DesfluraneIsoflurane

Intervention Hierarchy (Ancestors)

Ethyl EthersEthersOrganic ChemicalsMethyl EthersHydrocarbons, FluorinatedHydrocarbons, HalogenatedHydrocarbons

Study Officials

  • Allen Keebler, D.O.

    The Cleveland Clinic

    PRINCIPAL INVESTIGATOR
0

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Masking Details
Patients will not be told which type of volatile anesthetic they received.
Purpose
OTHER
Intervention Model
CROSSOVER
Model Details: Randomized cluster cross-over trial
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 22, 2024

First Posted

February 9, 2024

Study Start

December 8, 2023

Primary Completion

March 2, 2026

Study Completion

March 2, 2026

Last Updated

March 5, 2026

Record last verified: 2025-08

Data Sharing

IPD Sharing
Will not share

Locations

US(1)