Characterization of Ovarian Cancer Stem Cell

NCT01367353 | Unknown

• 1 other identifier: 200902010R
• Study Type: interventional
• Target: 250
• Locations: 1 country
• Sites: 1

Brief Summary

Specific aims: Identification and characterization of cancer stem cell-like population (cancer stem cells or cancer initiating cells) from primary tumor tissue, primary ascites and peripheral blood of ovarian cancer patients and genetically engineered mouse ovarian cancer cell lines. Objectives: In the future, individualized therapy must incorporate analysis of the cancer stem cells or cancer initiating cells of ovarian cancer cells when designing therapeutic strategies for ovarian cancer patients. Aims of this project:

1. 1.Isolation and identification of cancer stem cell-like population (cancer stem cells or cancer initiating cells) from primary tumor tissue, primary ascites and peripheral blood of ovarian cancer patients
2. 2.In vivo tumorigenicity assay will be performed to measure tumor formation from these cancer stem cell-like population when equal numbers were injected into the dorsal fat pad of nude mice.
3. 3.To establish a standard protocol of stem cell-like population maintenance
4. 4.Screening of potential specific biomarkers involved in these ovarian cancer stem cell-like population.

Conditions

Ovarian Cancer

Outcome Measures

Primary Outcomes (1)

• overall survival

  From disease diagnosis to death (Generally 2~5 years)

Study Arms (1)

ovarian cancer

EXPERIMENTAL

Procedure: surgery or debulking surgery

Interventions

surgery or debulking surgery PROCEDURE

surgery or debulking surgery

ovarian cancer

Eligibility Criteria

• Age: 15 Years - 80 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with ovarian carcinoma who undergo hysterectomy, bilateral oophorectomy and tubal resection, omentectomy, and appendectomy will be enrolled and the clinical data will be obtained from our hospital.

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, Taiwan

RECRUITING

MeSH Terms

Conditions

Ovarian Neoplasms

Interventions

Surgical Procedures, Operative

Condition Hierarchy (Ancestors)

Endocrine Gland Neoplasms; Neoplasms by Site; Neoplasms; Ovarian Diseases; Adnexal Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Neoplasms, Female; Urogenital Neoplasms; Genital Diseases; Endocrine System Diseases; Gonadal Disorders

Study Officials

• Wen-Fang Cheng, Professor

  National Taiwan University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Wen-Fang Cheng, Professor

CONTACT

886-2-23123456; wenfangcheng@yahoo.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: December 10, 2010
• First Posted: June 7, 2011
• Study Start: January 1, 2010
• Primary Completion: December 1, 2011
• Study Completion: December 1, 2013
• Last Updated: June 7, 2011

Record last verified: 2011-05

Locations

TW (1)