PTEN and IGFBP-3 Correlation in Ovarian Carcinoma Invasion

NCT00173407 | Withdrawn

• 1 other identifier: 9461700640
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

We have identified insulin-like growth factor binding protein (IGFBP)-3 as an invasion suppressor gene in ovarian endometrioid carcinoma, and showed association with lower cancer migration, invasion and metastasis. Recently, a novel model of ovarian EC formation from endometriosis was reported, and PTEN was found to be a major protein involved. Inactivation of PTEN has been reported in some ovarian EC tumors and methylation was suggested as one of the major epigenetic changes. This tumorigenesis model has lots of similarity to our established invasion model. Therefore, we plan to study the important of PTEN expression in ovarian EC and if inactivation of PTEN and IFGBP-3 is through methylation. Furthermore, by studying the signal transduction pathways using PTEN and IGFBP-3 transfection, we plan to study the mutual interaction between PTEN and IGFBP-3 on the suppression of tumor invasion in ovarian EC.

Conditions

Ovarian Cancer

Keywords

Ovarian endometrioid carcinoma; invasion; IGFBP-3; transfection; signal transduction; PTEN; methylation

Outcome Measures

Primary Outcomes (3)

• migration

• invasion

• metastasis

Secondary Outcomes (3)

• Immunohistochemical staining

• methylation

• signal tranduction

Interventions

immunohistochemical, methylation, gene transfection PROCEDURE

Eligibility Criteria

• Age: 21 Years - 80 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Clinical diagnosis of ovarian endometrioid carcinoma

You may not qualify if:

• other types of ovarian epithelial carcinoma

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, 10020, Taiwan

Location

MeSH Terms

Conditions

Ovarian Neoplasms

Interventions

Methylation

Condition Hierarchy (Ancestors)

Endocrine Gland Neoplasms; Neoplasms by Site; Neoplasms; Ovarian Diseases; Adnexal Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Neoplasms, Female; Urogenital Neoplasms; Genital Diseases; Endocrine System Diseases; Gonadal Disorders

Intervention Hierarchy (Ancestors)

Alkylation; Biochemical Phenomena; Chemical Phenomena; Organic Chemistry Phenomena; Metabolism

Study Officials

• Torng Pao-Ling, MD, PhD

  Department of Obstetric and Gynecology, National Taiwan University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 12, 2005
• First Posted: September 15, 2005
• Study Start: January 1, 2006
• Primary Completion: October 1, 2012
• Study Completion: October 1, 2012
• Last Updated: December 27, 2012

Record last verified: 2012-12

Locations

TW (1)