Seed Movement in Prostate Brachytherapy Implants: Clinical Measurement and Dosimetric Consequences
1 other identifier
observational
20
1 country
1
Brief Summary
There are substantial uncertainties with contemporary seed placement techniques in prostate brachytherapy, particularly with the impact of seed movement after an implant due to edema and migration of seeds in the prostate and peri-prostatic tissues. This study will accrue 20 patients undergoing prostate brachytherapy implants and perform serial CT and MRI scans at specified intervals (pre-operatively, day 0, day 3, day 10 and day 28) to characterize these phenomena.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Aug 2011
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 16, 2011
CompletedFirst Posted
Study publicly available on registry
May 18, 2011
CompletedStudy Start
First participant enrolled
August 1, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2015
CompletedOctober 3, 2014
October 1, 2014
3.8 years
May 16, 2011
October 1, 2014
Conditions
Keywords
Eligibility Criteria
Patients seen at an academic institution (tertiary centre ...Cross Cancer Institute) for consideration of prostate brachytherapy
You may qualify if:
- treated with prostate brachytherapy
- low risk or intermediate risk prostate cancer
- ambulatory
- stable medical condition
- years of age or older
- capable of informed consent
You may not qualify if:
- no use of any hormonal therapy
- unable to have MRI scans (ie. presence of metallic foreign object, aneurysm clip, cardiac pacemaker, internal wires, implanted pump, implanted cardiac device, claustrophobia, etc.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- AHS Cancer Control Albertalead
- Canadian Association of Radiation Oncologycollaborator
- Sanoficollaborator
Study Sites (1)
Cross Cancer Institute
Edmonton, Alberta, T6G 1Z2, Canada
Related Publications (1)
Sloboda RS, Usmani N, Pedersen J, Murtha A, Pervez N, Yee D. Time course of prostatic edema post permanent seed implant determined by magnetic resonance imaging. Brachytherapy. 2010 Oct-Dec;9(4):354-61. doi: 10.1016/j.brachy.2009.09.008. Epub 2010 Jan 29.
PMID: 20116344BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Nawaid Usmani, MD, FRCPC
University of Alberta
- PRINCIPAL INVESTIGATOR
Ronald Sloboda, PhD
University of Alberta
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 16, 2011
First Posted
May 18, 2011
Study Start
August 1, 2011
Primary Completion
June 1, 2015
Study Completion
June 1, 2015
Last Updated
October 3, 2014
Record last verified: 2014-10