NCT01344928

Brief Summary

The objectives of this study are to investigate the effects of short-time high-intensity interval training on tissue glucose and fat metabolism in healthy lean subjects and type 2 diabetic patients using modern and noninvasive imaging methods positron emission tomography (PET), magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS).

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 28, 2011

Completed
1 day until next milestone

First Posted

Study publicly available on registry

April 29, 2011

Completed
Last Updated

April 29, 2011

Status Verified

April 1, 2011

First QC Date

April 28, 2011

Last Update Submit

April 28, 2011

Conditions

Type 2 Diabetes MellitusHealthy Volunteers

Study Arms (2)

HIT training

EXPERIMENTAL
Behavioral: HIT exercise intervention

Aerobic exercise training

ACTIVE COMPARATOR
Behavioral: Aerobic exercise intervention

Interventions

HIT exercise interventionBEHAVIORAL
HIT training
Aerobic exercise interventionBEHAVIORAL
Aerobic exercise training

Eligibility Criteria

Age40 Years - 55 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • The healthy patients
  • Age 40-55
  • BMI 18.5-30
  • Fasting plasma glucose less than 6.1 mmol/l
  • Normal glucose tolerance test (OGTT)
  • The type 2 diabetic patients:
  • Age-, sex-, and BMI-matched with the study subjects in the phase 1
  • In a good treatment balance
  • Glycated haemoglobin (HbA1c) less than 7.5 mmol/l
  • Two hours glucose value in oral glucose tolerance test (OGTT) less than 10.0 mmol/l

You may not qualify if:

  • The healthy patients
  • Blood pressure \> 140/90 mmHg
  • Any chronic disease
  • Any chronic medical defect or injury which hinder/interfere everyday life
  • History of anorexia nervosa or bulimia
  • History of rest or exercise-induced asthma
  • Previous use of anabolic steroids, additives or any other substrates
  • Smoking of tobacco, taking of snuffs, or use of narcotics.
  • Significant use of alcohol
  • Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
  • Presence of any ferromagnetic objects that would make MR imaging contraindicated
  • Current or history of regular and systematic exercise training
  • VO2max \>40 ml/min/kg
  • The type 2 diabetic patients:
  • Any other chronic disease than diabetes
  • +9 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Turku PET Centre

Turku, 20521, Finland

RECRUITING

Related Publications (3)

  • Ojala R, Motiani KK, Ivaska KK, Arponen M, Eskelinen JJ, Virtanen KA, Loyttyniemi E, Heiskanen MA, U-Din M, Nuutila P, Kalliokoski KK, Hannukainen JC. Bone Marrow Metabolism Is Impaired in Insulin Resistance and Improves After Exercise Training. J Clin Endocrinol Metab. 2020 Dec 1;105(12):e4290-303. doi: 10.1210/clinem/dgaa516.

    PMID: 32785654DERIVED

  • Motiani KK, Collado MC, Eskelinen JJ, Virtanen KA, Loyttyniemi E, Salminen S, Nuutila P, Kalliokoski KK, Hannukainen JC. Exercise Training Modulates Gut Microbiota Profile and Improves Endotoxemia. Med Sci Sports Exerc. 2020 Jan;52(1):94-104. doi: 10.1249/MSS.0000000000002112.

    PMID: 31425383DERIVED

  • Heiskanen MA, Motiani KK, Mari A, Saunavaara V, Eskelinen JJ, Virtanen KA, Koivumaki M, Loyttyniemi E, Nuutila P, Kalliokoski KK, Hannukainen JC. Exercise training decreases pancreatic fat content and improves beta cell function regardless of baseline glucose tolerance: a randomised controlled trial. Diabetologia. 2018 Aug;61(8):1817-1828. doi: 10.1007/s00125-018-4627-x. Epub 2018 May 2.

    PMID: 29717337DERIVED

MeSH Terms

Conditions

Diabetes Mellitus, Type 2

Condition Hierarchy (Ancestors)

Diabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Study Design

Study Type
interventional
Phase
not applicable
Sponsor Type
OTHER GOV

Study Record Dates

First Submitted

April 28, 2011

First Posted

April 29, 2011

Last Updated

April 29, 2011

Record last verified: 2011-04

Locations

FI(1)