NCT01342978|Completed
Human Papillomavirus (HPV) Oral Transmission Study in Partners Over Time
HOTSPOT
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HOTSPOT
Sponsor study identifier
observational
242
1 country
4
Study Start
October 2009
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
December 2014
Actual (reported)Study Completion
January 2017
Actual (reported)This research is being done to understand more about a sexually transmitted virus called Human papillomavirus (HPV) in people with oropharyngeal cancer and their partners.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 2017
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
October 2009
Date type not reportedThis date has not been verified as actual or estimated.
March 7, 2011
Actual (reported)April 27, 2011
Actual (reported)December 2014
Actual (reported)January 2017
Actual (reported)HPV DNA detection in oral rinse sample
Detection of 17 types of HPV DNA in exfoliated oral cells of cases and partners collected using an oral rinse and gargle
baseline
208 oropharyngeal cancer cases were enrolled
110 partners of patients with oropharyngeal cancer were enrolled
A convenience group of 106 non-cancer controls were enrolled at some study sites at cancer screening events
cohort of cancer patients with matched enrollment of spouses and non-cancer controls
Johns Hopkins Hospital
Baltimore, Maryland, 21205, United States
Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
Mt Sinai School of Medicine
New York, New York, 10029, United States
Oregon Health & Science University
Portland, Oregon, 97239, United States
Anderson KS, Wong J, D'Souza G, Riemer AB, Lorch J, Haddad R, Pai SI, Longtine J, McClean M, LaBaer J, Kelsey KT, Posner M. Serum antibodies to the HPV16 proteome as biomarkers for head and neck cancer. Br J Cancer. 2011 Jun 7;104(12):1896-905. doi: 10.1038/bjc.2011.171.
D'Souza G, Gross ND, Pai SI, Haddad R, Anderson KS, Rajan S, Gerber J, Gillison ML, Posner MR. Oral human papillomavirus (HPV) infection in HPV-positive patients with oropharyngeal cancer and their partners. J Clin Oncol. 2014 Aug 10;32(23):2408-15. doi: 10.1200/JCO.2014.55.1341. Epub 2014 Apr 28.
Serum, oral rinse/saliva and some tumor samples
Gypsyamber D'Souza, PhD
Johns Hopkins Bloomberg School of Public Health
242 participants (actual enrollment reported by the registry).
First Submitted
March 7, 2011
First Posted
April 27, 2011
Study Start
October 2009
Date type not reportedThis date has not been verified as actual or estimated.
Human Papilloma Virus (HPV) Vaccination Among Rural African American Primary Caregivers and Daughters
Contact the study team to confirm eligibility.
Primary Completion
December 2014
Actual (reported)Study Completion
January 2017
Actual (reported)Last Updated
March 3, 2017
Record last verified: 2017-02
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Source: ClinicalTrials.gov.
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