Effect of Air Pollution in the Haifa Bay Area on Cardiovascular Morbidity and Mortality

NCT01325155 | Unknown DMC

• 1 other identifier: 0043-11CTIL
• Study Type: observational
• Target: 5,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

The association between exposure to ambient air pollution and pulmonary disease has been well established.To date no study has assessed the burden of cardiovascular disease in Israel and its relation to ambient air pollution. The Haifa Bay Area has a long history of industrialization including possessing the nation's largest oil refineries, oil-fired power plant, agrochemical and cement producers, industrial incinerators and the Eastern Mediterranean's busiest port. The presence of industrial and mobile sources, combined with a basin effect has contributed to air pollution in the Haifa Bay Area and has raised concerns about potential health effects. Research Objectives

• Determine if the increased rate of cardiovascular mortality in Haifa is associated with PM 2.5 concentrations.
• Assess effect modification in diverse sub-populations.
• If an association does exist, assess the economic burden of PM 2.5 associated cardiovascular morbidity and mortality.
• Design prediction models of daily cardiovascular emergency department visits based on daily and seasonal variation of air pollution.

Conditions

Acute Coronary Syndrome; Heart Failure; Arrhythmia

Keywords

Air Pollution; particulate matter; cardiovascular Disease

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All Patients visiting the ER between Jan 2009 and Dec 2010 at the Rambam Medical Center in Haifa Israel. Electronic medical record databases will be queried for ICD-9 codes of related cardiac (acute coronary syndrome, heart failure, dysrhythmia/conduction disturbance) diagnoses.

You may qualify if:

• All Patients visiting the ER between Jan 2009 and Dec 2010 at the Rambam Medical Center in Haifa Israel.

Sponsors & Collaborators

• Rambam Health Care Campus: lead

MeSH Terms

Conditions

Acute Coronary Syndrome; Heart Failure; Arrhythmias, Cardiac; Cardiovascular Diseases

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Vascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Haim Hammerman, prof

  Rambam Health Care Campus

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Amir Solomonica, MD MPH

CONTACT

972502062691; a_solomonica@rambam.health.gov.il

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: March 27, 2011
• First Posted: March 29, 2011
• Study Start: April 1, 2011
• Last Updated: March 29, 2011

Record last verified: 2011-03