NCT01315613|Completed
Role of ST2 in Acute Pancreatitis
Study of ST2-IL-33 Pathway in Acute Pancreatitis
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Study of ST2-IL-33 Pathway in Acute Pancreatitis
Sponsor study identifier
observational
44
1 country
1
Study Start
January 2005
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
September 2008
Actual (reported)Study Completion
September 2008
Date type not reportedThis date has not been verified as actual or estimated.
Acute pancreatitis is characterized by an inflammatory storm which regulatory pathways are not well known. The IL-1 cytokine family is activated early during acute pancreatitis and secretion of alarmins is speculated during pancreatic necrosis. IL-33 is a member of the IL-1 family, it can act as an alarmin and its receptor, ST2, is known to sequester MyD88 which might regulate the acute pancreatitis inflammatory storm. The aim of this study is to investigate ST2 pathway in human acute pancreatitis and in murine experimental models of acute pancreatitis.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
September 2008
Date type not reportedThis date has not been verified as actual or estimated.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 2005
Date type not reportedThis date has not been verified as actual or estimated.
September 2008
Actual (reported)September 2008
Date type not reportedThis date has not been verified as actual or estimated.
March 11, 2011
Actual (reported)March 15, 2011
Actual (reported)Concentration of soluble ST2 in serum
Concentration of soluble ST2 will be assessed in the serum of patient with an episode of acute pancreatitis, on the day of admission to the hospital as well as 24h, 48h, 7 days and 30 days later.
Within 30 days after onset of acute pancreatitis
Patients admitted in our institution for an episode of acute pancreatitis
Patients of Erasme University Hospital
Erasme Hospital
Brussels, 1070, Belgium
Romy Ouziel, MD
Erasme University Hospital
44 participants (actual enrollment reported by the registry).
First Submitted
March 11, 2011
First Posted
March 15, 2011
Study Start
January 2005
Date type not reportedThis date has not been verified as actual or estimated.
Contact the study team to confirm eligibility.
Primary Completion
September 2008
Actual (reported)Study Completion
September 2008
Date type not reportedThis date has not been verified as actual or estimated.
Last Updated
March 15, 2011
Record last verified: 2008-09
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Source: ClinicalTrials.gov.
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