NCT01300403

Brief Summary

This study aimed to evaluate the acute physiological effects of expiration with the glottis open in lateral posture (ELTGOL) and Flutter valve in dynamic and static lung volumes in patients with bronchiectasis and, secondarily, to study the effect of these techniques in sputum production.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
10

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jun 2009

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2009

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2010

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2010

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

February 18, 2011

Completed
3 days until next milestone

First Posted

Study publicly available on registry

February 21, 2011

Completed
Last Updated

February 21, 2011

Status Verified

September 1, 2010

Enrollment Period

1.2 years

First QC Date

February 18, 2011

Last Update Submit

February 18, 2011

Conditions

Outcome Measures

Primary Outcomes (1)

  • Dynamic and static lung volumes

    Dynamic and static lung volumes were assessed by forced spirometry and plethysmography.

    In the week 1, 2 and 3. Before (baseline) and after each intervention.

Secondary Outcomes (1)

  • Sputum production

    Sputum was colected during the interventions

Study Arms (3)

FLUTTER

EXPERIMENTAL

Since this was a crossover study, all patients performed all interventions in a randomized order.

Other: Flutter valve

ELTGOL

EXPERIMENTAL

Since this was a crossover study, all patients performed all interventions in a randomized order.

Other: expiration with the glottis open in lateral posture (ELTGOL)

CONTROL

ACTIVE COMPARATOR

Since this was a crossover study, all patients performed all interventions in a randomized order.

Other: Control

Interventions

Flutter valve is a physiotherapy device commonly used for the treatment of pulmonary hypersecretive conditions. The patients is taught to exhale through the device, producing positive expiratory pressure and flow oscillations. In this study the intervention took 15 minutes. During this period the patients were free to cough.

FLUTTER

This technique is a maneuver of slow expiration with the glottis open, with the subject in lateral posture. The patients performed three sets of 10 repetitions in left and right lateral decubitus.

ELTGOL
ControlOTHER

Patients were instructed to stay comfortably seated during 15 minutes. After this period they were stimulated to cough during a five minutes period.

CONTROL

Eligibility Criteria

Age18 Years - 60 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Patients with clinical and radiological criteria of bronchiectasis

You may not qualify if:

  • heart failure
  • pneumonia
  • chest pain
  • inability to perform the procedures
  • asthma
  • cystic fibrosis

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Hospital Universitário Pedro Ernesto

Rio de Janeiro, Rio de Janeiro, 20550-170, Brazil

Location

MeSH Terms

Conditions

Bronchiectasis

Interventions

Exhalation

Condition Hierarchy (Ancestors)

Bronchial DiseasesRespiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Respiratory MechanicsRespirationRespiratory Physiological PhenomenaCirculatory and Respiratory Physiological Phenomena

Study Officials

  • Fernando S Guimarães, PhD

    Universidade Federal do Rio de Janeiro

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
OTHER

Study Record Dates

First Submitted

February 18, 2011

First Posted

February 21, 2011

Study Start

June 1, 2009

Primary Completion

August 1, 2010

Study Completion

August 1, 2010

Last Updated

February 21, 2011

Record last verified: 2010-09

Locations