MEG and DTI of Neural Function and Connectivity in Traumatic Brain Injury

NCT01298557 | Completed DMC

• 1 other identifier: Dana-REAC
• Study Type: observational
• Target: 69
• Locations: 1 country
• Sites: 1

Brief Summary

The overall hypothesis is that the long-term cognitive and behavioral sequelae of traumatic brain injury (TBI) are due to selective disruption of the long association white matter tracts of the cerebral hemispheres, with resulting functional impairment of the network of cortical regions that are interconnected by these long-range association pathways. We propose that traumatic white matter injury can be measured with diffusion tensor imaging (DTI) and that the impaired cortical activation can be detected with magnetoencephalography (MEG), and that the results of these imaging examinations will correlate with neurocognitive status and functional recovery after TBI.

Conditions

Traumatic Brain Injury; Post-concussive Symptoms

Keywords

Traumatic brain injury; Post-concussive symptoms; Brain imaging; Neurocognitive testing

Outcome Measures

Primary Outcomes (1)

• Changes in white matter tract structure

  We believe that brain injury results in selective disruption of the associative white matter tracts of the cerebral hemispheres, with resulting functional impairment of the network of cortical regions that are interconnected by these long-range association pathways. We propose that traumatic white matter injury can be measured with diffusion tensor imaging (DTI). We evaluate DTI using 3T and 7T MRI. Participants receive scans at only one time-point.

  up to 4 years following date of injury

Secondary Outcomes (2)

• Neurocognitive function

  up to 4 years following date of injury

• Cortical activation

  up to 4 years following date of injury

Study Arms (2)

Traumatic brain injured patients

This group consists of participants who suffered a traumatic brain injury an average of 4 months to 4 years prior to testing. Patients must not have history of prior head injury, substance abuse, psychiatric illness, or contraindications to MRI.

Controls (no traumatic brain injury)

This group consists of participants who do not have a history of brain trauma. Furthermore, controls must not suffer from substance abuse, psychiatric illness, or have contraindications to the MRI.

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Participants will be recruited through the neurosurgery clinic at San Francisco General Hospital or referred to us by colleagues.

You may qualify if:

• years of age
• single episode of blunt traumatic brain injury
• symptoms of persistent post-concussive syndrome present an average of 4 months to 4 years since date of injury
• fluency in English (cognitive battery not available in other languages)
• capable of self-consent

You may not qualify if:

• \< 18 years or \> 50 years of age
• pregnancy
• history of previous TBI with loss of consciousness
• alcoholism as evidenced by Audit questionnaire
• regular use of illicit drugs
• non-English fluency
• significant psychiatric history excluding mild depression or anxiety disorder any contraindication to MRI, including claustrophobia, pregnancy, any trauma or surgery which may have left ferromagnetic material in the body, ferromagnetic implants or pacemakers; and inability to lie still for 1 hour or more

Sponsors & Collaborators

• University of California, San Francisco: lead

Study Sites (1)

San Francisco General Hospital

San Francisco, California, 94110, United States

Location

Related Publications (5)

• Arfanakis K, Haughton VM, Carew JD, Rogers BP, Dempsey RJ, Meyerand ME. Diffusion tensor MR imaging in diffuse axonal injury. AJNR Am J Neuroradiol. 2002 May;23(5):794-802.

  PMID: 12006280 BACKGROUND

• Deipolyi AR, Mukherjee P, Gill K, Henry RG, Partridge SC, Veeraraghavan S, Jin H, Lu Y, Miller SP, Ferriero DM, Vigneron DB, Barkovich AJ. Comparing microstructural and macrostructural development of the cerebral cortex in premature newborns: diffusion tensor imaging versus cortical gyration. Neuroimage. 2005 Sep;27(3):579-86. doi: 10.1016/j.neuroimage.2005.04.027.

  PMID: 15921934 BACKGROUND

• Hillebrand A, Singh KD, Holliday IE, Furlong PL, Barnes GR. A new approach to neuroimaging with magnetoencephalography. Hum Brain Mapp. 2005 Jun;25(2):199-211. doi: 10.1002/hbm.20102.

  PMID: 15846771 BACKGROUND

• Hughes DG, Jackson A, Mason DL, Berry E, Hollis S, Yates DW. Abnormalities on magnetic resonance imaging seen acutely following mild traumatic brain injury: correlation with neuropsychological tests and delayed recovery. Neuroradiology. 2004 Jul;46(7):550-8. doi: 10.1007/s00234-004-1227-x. Epub 2004 Jun 8.

  PMID: 15185054 BACKGROUND

• Huisman TA, Sorensen AG, Hergan K, Gonzalez RG, Schaefer PW. Diffusion-weighted imaging for the evaluation of diffuse axonal injury in closed head injury. J Comput Assist Tomogr. 2003 Jan-Feb;27(1):5-11. doi: 10.1097/00004728-200301000-00002.

  PMID: 12544235 BACKGROUND

MeSH Terms

Conditions

Brain Injuries, Traumatic; Post-Concussion Syndrome

Condition Hierarchy (Ancestors)

Brain Injuries; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries; Brain Concussion; Head Injuries, Closed; Wounds, Nonpenetrating

Study Officials

• Pratik Mukherjee, MD, PhD

  UCSF Department of Radiology and Bioengineering

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 9, 2011
• First Posted: February 17, 2011
• Study Start: February 1, 2007
• Primary Completion: February 1, 2013
• Study Completion: February 1, 2013
• Last Updated: December 4, 2018

Record last verified: 2018-11

Locations

US (1)