Perception Processing in Schizophrenia Patients and Normal Population

NCT01298349 | Completed DMC

• 1 other identifier: 104-10
• Study Type: observational
• Target: 71
• Locations: 1 country
• Sites: 1

Brief Summary

The present study aimed to examine face and object perception processes in schizophrenic patients. Schizophrenia is associated with deficits in visual processing that represent a key feature in the disorder. Previous studies have shown that schizophrenics exhibit deficits in a variety of facial-processing tasks (e.g., face recognition, recognition of facial expressions), that may severely hinder the patients' interpersonal and social skills. Some investigators have attributed these deficits to impairments in configural processing in schizophrenia. That is, an impairment in the ability to process the spatial relations between the constituent parts of a configuration (e.g., the spacing between the eyes of a given face). To date, studies aimed to investigate this possibility (e.g., Schwartz et al., 2002; Yong-Wook et al., 2008) yielded conflicting results. Additionally, it is not yet clear whether the hypothesized impairment in configural processing is restricted to faces, or whether it is more general in nature and applies to objects as well.

Conditions

Schizophrenia; Normal Population

Outcome Measures

Primary Outcomes (3)

• Performance in Experiment 1: Probability of Global Perception (%)

  The probabilities (in percentage) of choosing the comparison figure having the same configuration as the standard figure. That is, the ratio between the number of trials in which participants chose the comparison figure as having the same configuration as the standard figure, and the total number of trials.

  2 weeks.

• Performance in Experiment 2: Response Time (milliseconds)

  Response Time in milliseconds; will be measured from stimulus onset on screen until prticipant's response.

  2 weeks.

• Performance in Experiment 2: Error Rate (%)

  Percentage of Errors; The ratio between number of errors and the total number of responses.

  2 weeks.

Study Arms (2)

schizophrenic patients

normal population

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients diagnosed with schizophrenia or schizo-affective disorder according to DSM4 and normal population with no psychiatric history

You may qualify if:

• schizophrenia or schizo-affective disorder
• normal population with no psychiatric history
• Stable medication for at least a month before participating in the study
• subjects must have normal vision or revised

You may not qualify if:

• deterioration of the disorder
• subject will

Sponsors & Collaborators

• HaEmek Medical Center, Israel: lead

Study Sites (1)

Haemek Medical Center

Afula, Israel

Location

MeSH Terms

Conditions

Schizophrenia

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Study Officials

• Boaz Bloch, MD

  Haemek Mediacl Center

  PRINCIPAL INVESTIGATOR

• Alon Reshef, MD

  haemek medical center

  STUDY CHAIR

• Rama Amishav, Phd

  haemek medical center

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 2, 2010
• First Posted: February 17, 2011
• Study Start: February 1, 2011
• Primary Completion: December 1, 2016
• Study Completion: December 1, 2017
• Last Updated: February 17, 2020

Record last verified: 2020-02

Locations

IL (1)