NCT01281657

Brief Summary

The purpose of this observational study is to collect long-term data on safety and effectiveness of fingolimod, particularly including clinical disease and patient outcome related parameters such as relapse and disability, in patients who have participated in prior trials within the fingolimod clinical development program. Furthermore, this study explores the incidence of selected safety related outcomes of fingolimod treatment during follow-up visits within the context of routine medical practice.

Trial Health

90
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
64

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Feb 2011

Geographic Reach
2 countries

58 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 19, 2011

Completed
5 days until next milestone

First Posted

Study publicly available on registry

January 24, 2011

Completed
8 days until next milestone

Study Start

First participant enrolled

February 1, 2011

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2012

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2012

Completed
Last Updated

September 6, 2012

Status Verified

September 1, 2012

Enrollment Period

1.4 years

First QC Date

January 19, 2011

Last Update Submit

September 5, 2012

Conditions

Keywords

FingolimodFTY720Relapsing forms of multiple sclerosisMultiple sclerosisMSSafetyEfficacy

Outcome Measures

Primary Outcomes (1)

  • Long-term safety data in patients with relapsing forms of multiple sclerosis who have participated in clinical trials with fingolimod and who are now taking prescribed fingolimod under the conditions of routine medical practice

    Throughout the entirety of the study up to a maximum of 8 years

Secondary Outcomes (1)

  • Long-term effectiveness data, particularly including clinical disease and patient outcome related parameters such as relapse and disability

    Throughout the entirety of the study up to a maximum of 8 years

Study Arms (1)

Prescribed fingolimod 0.5 mg/day

Drug: fingolimod

Interventions

Prescribed fingolimod 0.5 mg/day

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients with relapsing forms of MS who have participated in previous fingolimod trials and now taking commercially available fingolimod as part of routine medical care

You may qualify if:

  • Patients who are prescribed fingolimod as part of their routine medical care
  • Patients who have participated in a prior fingolimod clinical trials

You may not qualify if:

  • Restrictions regarding the use of fingolimod while pregnant or nursing in accordance with the local prescribing label
  • Any patient who has prematurely discontinued from the previous fingolimod trial

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (58)

North Central Neurology Associates, PC

Cullman, Alabama, 35058, United States

Location

The Research & Education Inst. of Alta Bates Summit Med. Grp

Berkeley, California, 94705, United States

Location

Neuro-Therapeutics, Inc.

Pasadena, California, 91105, United States

Location

University of California San Francisco

San Francisco, California, 94117, United States

Location

Yale Multiple Sclerosis Center

New Haven, Connecticut, 06510, United States

Location

Georgetown University/Lombardi Cancer Center

Washington D.C., District of Columbia, 20007, United States

Location

Sunrise Clinical Research, Inc.

Hollywood, Florida, 33021, United States

Location

University of Florida

Jacksonville, Florida, 32209, United States

Location

University of Miami

Miami, Florida, 33136, United States

Location

Neurological Associates

Pompano Beach, Florida, 33060, United States

Location

Neurology Clinical Research, Inc.

Sunrise, Florida, 33351, United States

Location

AMO Corporation

Tallahassee, Florida, 32308, United States

Location

MS Center of Vero Beach

Vero Beach, Florida, 32960, United States

Location

South Suburban Neurology

Flossmoor, Illinois, 60422, United States

Location

Neurologic Associates, LTD

Palos Heights, Illinois, 60463, United States

Location

Mercy Ruan Neurology Clinic Res Ct.

Des Moines, Iowa, 50314, United States

Location

University of Kansas Medical Center

Kansas City, Kansas, 66160, United States

Location

Mid America Neuroscience Institute

Lenexa, Kansas, 66214, United States

Location

University of Maryland

Baltimore, Maryland, 21201, United States

Location

Johns Hopkins MS Center

Baltimore, Maryland, 21287, United States

Location

Caritas St. Elizabeth's Hospital

Boston, Massachusetts, 02135, United States

Location

Springfield Neurology Associates, LLC

Springfield, Massachusetts, 01104, United States

Location

Spectrum Health Medical Group, Neurology

Grand Rapids, Michigan, 49525, United States

Location

Saint Luke's Hospital

Kansas City, Missouri, 64111, United States

Location

The MS Center for Innovation in Care

St Louis, Missouri, 63131, United States

Location

University of New Mexico Health Science Center

Albuquerque, New Mexico, 87131, United States

Location

Mount Sinai School of Medicine

New York, New York, 10029, United States

Location

Island Neurological Associates

Plainview, New York, 11803, United States

Location

SUNY - Stony Brook University

Stony Brook, New York, 11794, United States

Location

University of Toledo Health Science Campus

Toledo, Ohio, 43614, United States

Location

MS Center of Oklahoma

Oklahoma City, Oklahoma, 73120, United States

Location

Neurological Associates of Tulsa, Inc

Tulsa, Oklahoma, 74137, United States

Location

University of Pennsylvania Health System

Philadelphia, Pennsylvania, 19104, United States

Location

Thomas Jerfferson University Hospital

Philadelphia, Pennsylvania, 19107, United States

Location

Vanderbilt University

Nashville, Tennessee, 37204, United States

Location

University of Texas Medical School

Houston, Texas, 77030, United States

Location

Integra Clinical Research

San Antonio, Texas, 78231, United States

Location

University of Virginia Health System

Charlottesville, Virginia, 22903, United States

Location

Swedish Neuroscience Institute

Seattle, Washington, 98122, United States

Location

Dean Foundation

Madison, Wisconsin, 53715, United States

Location

University of Wisconsin Madison

Madison, Wisconsin, 53792, United States

Location

St. Luke's Medical Center

Milwaukee, Wisconsin, 53215, United States

Location

Novartis Investigative Site

Burnaby, British Columbia, V5G 2X6, Canada

Location

Novartis Investigative Site

Vancouver, British Columbia, V6T 2B5, Canada

Location

Novartis Investigative Site

Victoria, British Columbia, V8R 1J8, Canada

Location

Novartis Investigative Site

Halifax, Nova Scotia, B3H 4K4, Canada

Location

Novartis Investigative Site

Kingston, Ontario, K7L 2V7, Canada

Location

Novartis Investigative Site

London, Ontario, N6A 5A5, Canada

Location

Novartis Investigative Site

Nepean, Ontario, K2G 6E2, Canada

Location

Novartis Investigative Site

Ottawa, Ontario, K1H 8L6, Canada

Location

Novartis Investigative Site

Toronto, Ontario, M5B 1W8, Canada

Location

Novartis Investigative Site

Greenfield Park, Quebec, J4V 2J2, Canada

Location

Novartis Investigative Site

Montreal, Quebec, H1T 2M4, Canada

Location

Novartis Investigative Site

Montreal, Quebec, H2L 4M1, Canada

Location

Novartis Investigative Site

Montreal, Quebec, H3A 2B4, Canada

Location

Novartis Investigative Site

Québec, Quebec, G1J 1Z4, Canada

Location

Novartis Investigative Site

Sherbrooke, Quebec, J1H 5N4, Canada

Location

Novartis Investigative Site

Regina, Saskatchewan, S4T 1A5, Canada

Location

MeSH Terms

Conditions

Multiple Sclerosis

Interventions

Fingolimod Hydrochloride

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNSAutoimmune Diseases of the Nervous SystemNervous System DiseasesDemyelinating DiseasesAutoimmune DiseasesImmune System Diseases

Intervention Hierarchy (Ancestors)

SphingosineAmino AlcoholsAlcoholsOrganic ChemicalsPropylene GlycolsGlycolsAmines

Study Officials

  • Novartis Pharmaceuticals

    Novartis Pharmaceuticals

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 19, 2011

First Posted

January 24, 2011

Study Start

February 1, 2011

Primary Completion

July 1, 2012

Study Completion

July 1, 2012

Last Updated

September 6, 2012

Record last verified: 2012-09

Locations