Computerized Neuropsychology in Idiopathic Normal Pressure Hydrocephalus (INPH)

NCT01265251 | Completed

• 1 other identifier: 07-088M
• Study Type: observational
• Target: 97
• Locations: 1 country
• Sites: 1

Brief Summary

A computerised neuropsychological test battery to be used as a standardised tool assessing the cognitive domains affected by idiopathic normal pressure hydrocephalus INPH was developed. The aim of this study is to investigate the reliability, validity and feasibility of the battery.

Conditions

Normal Pressure Hydrocephalus

Keywords

Normal Pressure Hydrocephalus; Neuropsychological Test; Assessment of cognitive disorders/dementia; Neuropsychological assessment

Outcome Measures

Primary Outcomes (3)

• Validity

  Computerized test battery and equivalent standard neuropsychological test battery is given to the same subject. Correlation between paper and pen and equivalent computerized test is calculated as a validity measure.

  Within 24 h

• Reliability

  The computerized test battery is given to the same subject twice. Correlation between the two tests is calculated as a test-retest reliability measure.

  More than 7 days, within 2 months

• Feasibility

  Patients under the investigation for INPH are given the computerized test battery. Number of patients who manage to complete the test is the feasibility measure.

  Within 24 h

Study Arms (3)

Test-retest

Forty-four healthy elderly 60-82 years old

Device: Computerized neuropsychological test

Validity

Twenty six patients with various diseases and various ages

Device: Computerized neuropsychological test; Other: Conventional neuropsychological test

Feasibility

Twenty seven patients under the preoperative investigation for INPH

Device: Computerized neuropsychological test

Interventions

Computerized neuropsychological test DEVICE

Computerized neuropsychological test battery.

Feasibility; Test-retest; Validity

Conventional neuropsychological test OTHER

Conventional neuropsychological test (paper and pen)

Validity

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Reliability: Healthy elderly Validity: Various diseases Feasibility: Possible INPH-patients

You may qualify if:

• Probable INPH under investigation
• Healthy elderly
• Various diseases

You may not qualify if:

• (Healthy elderly) medications affecting nervous system
• (Healthy elderly)heart disease
• (Healthy elderly)diabetes
• (Healthy elderly)disease of the nervous system
• (Healthy elderly)MMSE \< 28
• (Healthy elderly)vascular risk factors (Two of: 1 hypertension, 2 smoking or 3 hyperlipidemia)
• (Healthy elderly)serious disease that may shorten life expectancy
• (Various diseases) Affected motor functions

Sponsors & Collaborators

• Umeå University: lead

Study Sites (1)

Department of Clinical Neuroscience

Umeå, Västerbotten County, SE-901 85, Sweden

Location

Related Publications (1)

• Behrens A, Eklund A, Elgh E, Smith C, Williams MA, Malm J. A computerized neuropsychological test battery designed for idiopathic normal pressure hydrocephalus. Fluids Barriers CNS. 2014 Sep 25;11:22. doi: 10.1186/2045-8118-11-22. eCollection 2014.

  PMID: 25279138 DERIVED

MeSH Terms

Conditions

Hydrocephalus, Normal Pressure; Dementia

Condition Hierarchy (Ancestors)

Hydrocephalus; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders

Study Officials

• Anders Behrens, M.D., M.Sc.

  Department of Clinical Neuroscience

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: December 21, 2010
• First Posted: December 23, 2010
• Study Start: August 1, 2007
• Primary Completion: April 1, 2010
• Study Completion: April 1, 2010
• Last Updated: December 23, 2010

Record last verified: 2010-12

Locations

SE (1)