NCT01257490

Brief Summary

This study recruited cigarette smokers under supervision in community corrections (e.g., probation, parole, drug courts, etc.) in the Birmingham, Alabama area. Smokers received 12 weeks of bupropion treatment and brief physician advice to quit smoking or 12 weeks of bupropion treatment and 4 sessions of intensive counseling around smoking cessation. The study was stratified on race such that equal proportions of African Americans and Caucasians were enrolled in the two study groups. It was hypothesized that smokers receiving intensive counseling will have higher quit rates compared to smokers receiving brief advice to quit.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
689

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Oct 2009

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2009

Completed
1.1 years until next milestone

First Submitted

Initial submission to the registry

October 28, 2010

Completed
1 month until next milestone

First Posted

Study publicly available on registry

December 9, 2010

Completed
3.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2014

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2014

Completed
Last Updated

April 18, 2017

Status Verified

April 1, 2017

Enrollment Period

4.4 years

First QC Date

October 28, 2010

Last Update Submit

April 17, 2017

Conditions

Outcome Measures

Primary Outcomes (4)

  • smoking cessation

    3 months

  • smoking cessation

    6 Month

  • smoking cessation

    9 Month

  • smoking cessation

    12 Month

Study Arms (2)

Intensive counseling

EXPERIMENTAL

4 sessions of intensive counseling plus bupropion

Behavioral: counseling vs. advice

Brief Counseling

ACTIVE COMPARATOR

Brief physician advice to quit plus bupropion

Behavioral: counseling vs. advice

Interventions

1 session of brief physician advice to quit smoking plus bupropion (12 weeks) compared to 4 sessions of intensive counseling plus bupropion (12 weeks)

Also known as: counseling, wellbutrin, bupropion, zyban
Brief CounselingIntensive counseling

Eligibility Criteria

Age19 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • At least 19 years or older
  • Enrolled in criminal justice community supervision (e.g., probation, parole, drug court, community corrections, etc)
  • Smoking at least 5 cpd for the past year
  • Maintained in an unrestricted environment (e.g., not currently in a correctional facility or treatment facility) living in the Birmingham Area and surrounding communities

You may not qualify if:

  • Pregnant or nursing (all women in this study will be required to use an acceptable form of contraception throughout the administration of the medication)
  • Known sensitivity to Zyban or Wellbutrin
  • History of seizures
  • Current or prior anorexia or bulimia
  • Abrupt withdrawal from alcohol or benzodiazepines
  • Moderate to severe kidney problems
  • Moderate liver problems
  • Cognitive impairment such that they cannot provide informed consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

UAB Substance Abuse

Birmingham, Alabama, 35209, United States

Location

MeSH Terms

Conditions

Smoking Cessation

Interventions

CounselingBupropion

Condition Hierarchy (Ancestors)

Health BehaviorBehavior

Intervention Hierarchy (Ancestors)

Mental Health ServicesBehavioral Disciplines and ActivitiesCommunity Health ServicesHealth ServicesHealth Care Facilities Workforce and ServicesPropiophenonesKetonesOrganic Chemicals

Study Officials

  • Karen L Cropsey, Psy.D.

    University of Alabama at Birmingham

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

October 28, 2010

First Posted

December 9, 2010

Study Start

October 1, 2009

Primary Completion

March 1, 2014

Study Completion

March 1, 2014

Last Updated

April 18, 2017

Record last verified: 2017-04

Locations