A Multicenter Observational Study of Invasive Candida Infections Among ICU Patients in China

NCT01253954 | Unknown

• 1 other identifier: 1234
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

The incidence of invasive candida infection (ICI) in critically ill patients is increasing day by day. The crude mortality of IFI in ICU could be as high as 25%-75% depending on their age, underlying conditions, and so on. Candida albicans was by far the predominant species in most countries, causing up to two thirds of all cases of invasive candidiasis. However, a shift toward non-albicans Candida species has been observed. Although the studies of ICI cause universal attention recently, there is still no large-scale, multi-center epidemiological research in China focusing on ICI in critically ill patients, therefore we conducted a large-scale multi-center observational study of IFI in critically ill patients named "China Scan" (CHINA Survey of Candidiasis in ICU) to assess the current incidence, mortality, pathogen spectrum, management, and risk factors for ICI in China ICUs.

Conditions

Candidiasis

Keywords

invasive candida infection

Outcome Measures

Primary Outcomes (1)

• Determine the current incidence and in-hospital mortality of invasive candidas infection in ICUs in China.

  300 charactors

Secondary Outcomes (1)

• Describe the risk factors for ICI in China ICUs. Explore the pathogen spectrum of ICI in ICUs in China. Describe the in vitro antifungal susceptibility of Candida isolates. Describe the antifungal treatment for ICU patients with ICI.

  300 charactors

Study Arms (1)

ICU patients with IFI

1

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult ICU patients above 18 with invasive candida infection

You may qualify if:

• Adult ICU patients above 18 with ICI-

You may not qualify if:

• Non ICI-

Sponsors & Collaborators

• Southeast University, China: lead
• QLT Inc.: collaborator

Study Sites (1)

Gulou District

Nanjing, Jiangsu, 210009, China

RECRUITING

Related Publications (2)

• Cui N, Wang H, Su L, Qiu H, Li R, Liu D; China-SCAN Team. Initial therapeutic strategy of invasive candidiasis for intensive care unit patients: a retrospective analysis from the China-SCAN study. BMC Infect Dis. 2017 Jan 23;17(1):93. doi: 10.1186/s12879-017-2207-1.

  PMID: 28114898 DERIVED

• Guo F, Yang Y, Kang Y, Zang B, Cui W, Qin B, Qin Y, Fang Q, Qin T, Jiang D, Li W, Gu Q, Zhao H, Liu D, Guan X, Li J, Ma X, Yu K, Chan D, Yan J, Tang Y, Liu W, Li R, Qiu H; China-SCAN Team. Invasive candidiasis in intensive care units in China: a multicentre prospective observational study. J Antimicrob Chemother. 2013 Jul;68(7):1660-8. doi: 10.1093/jac/dkt083. Epub 2013 Mar 29.

  PMID: 23543609 DERIVED

MeSH Terms

Conditions

Candidiasis

Condition Hierarchy (Ancestors)

Mycoses; Bacterial Infections and Mycoses; Infections

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: December 3, 2010
• First Posted: December 6, 2010
• Study Start: November 1, 2009
• Primary Completion: April 1, 2011
• Study Completion: April 1, 2011
• Last Updated: December 6, 2010

Record last verified: 2009-11

Locations

CN (1)