CAROLINA: Cardiovascular Outcome Study of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes
A Multicentre, International, Randomised, Parallel Group, Double Blind Study to Evaluate Cardiovascular Safety of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes Mellitus at High Cardiovascular Risk.
2 other identifiers
interventional
6,103
42 countries
604
Brief Summary
The aim of the study is to investigate the longterm impact on cardiovascular morbidity and mortality, relevant efficacy parameters (e.g., glycaemic parameters) and safety (e.g., weight and hypoglycaemia) of treatment with linagliptin in patients with type 2 diabetes at elevated cardiovascular risk receiving usual care, and compare outcome against glimepiride.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 diabetes-mellitus-type-2
Started Nov 2010
Longer than P75 for phase_3 diabetes-mellitus-type-2
604 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 11, 2010
CompletedFirst Submitted
Initial submission to the registry
November 17, 2010
CompletedFirst Posted
Study publicly available on registry
November 18, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 21, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
August 21, 2018
CompletedResults Posted
Study results publicly available
January 7, 2020
CompletedJanuary 7, 2020
December 1, 2019
7.8 years
November 17, 2010
August 21, 2019
December 19, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
The First 3-point Major Adverse Cardiovascular Events (3P-MACE)
The first occurrence of any of the following Clinical Event Committee (CEC) confirmed adjudicated components of the primary composite endpoint: CV death (including fatal stroke and fatal myocardial infarction (MI)), non-fatal MI (excluding silent MI), or nonfatal stroke is presented.
From randomization until individual day of trial completion, up to 432 weeks
Secondary Outcomes (19)
The First 4-point (4P)- MACE
From randomization until individual day of trial completion, up to 432 weeks
Percentage of Participants Taking Trial Medication at Trial End, Maintained Glycaemic Control (HbA1c ≤7.0%) Without Need for Rescue Medication, Without >2% Weight Gain, and Without Moderate/Severe Hypoglycaemic Episodes During Maintenance Phase
From Visit 6 (Week 16) to Final visit (Week 432) (Maintenance Phase)
Percentage of Participants Who Were on Trial Medication at Trial End, Maintained Glycaemic Control (HbA1c ≤7.0%) Without Need for Rescue Medication, and Without >2% Weight Gain During Maintenance Phase
From Visit 6 (Week 16) to Final visit (Week 432) (Maintenance Phase)
Percentage of Participants With the Occurrence of at Least One Event of 3P-MACE
From randomization until individual day of trial completion, up to 432 weeks
Percentage of Participants With the Occurrence of at Least One Event of 4P -MACE
From randomization until individual day of trial completion, up to 432 weeks
- +14 more secondary outcomes
Study Arms (2)
linagliptin
EXPERIMENTALpatient to receive linagliptin or glimepiride placebo over encapsulated tablet Quaque die (QD)
glimepiride 1-4 mg QD
ACTIVE COMPARATORpatient to receive glimepiride 1-4 mg or linagliptin placebo tablet Quaque die (QD)
Interventions
Eligibility Criteria
You may qualify if:
- Type 2 diabetes
- Elevated glycosylated haemoglobin (HbA1c): 6.5 - 8.5%, inclusive, if treatment naïve or mono-/dual therapy with metformin and/or an alpha-glucosidase inhibitor; 6.5 - 7.5%, inclusive, if treatment with sulphonylurea/glinide in mono- or dual (with metformin OR an alpha-glucosidase inhibitor) therapy)
- Pre-existing cardiovascular disease OR specified diabetes end-organ damage OR age =\> 70 years OR two or more specified cardiovascular risk factor
- BMI =\< 45kg/m²
- age between \>= 40 and =\< 85 years
- signed and dated written International Conference of Harmonisation( ICF)
- stable anti-diabetic background for at least 8 wks before study start
You may not qualify if:
- Type 1 diabetes
- Treatment with other antidiabetic drugs (e.g. rosiglitazone, pioglitazone, Glucagon-like peptide 1 (GLP-1) analogue/agonists, Dipeptidyl-peptidase IV (DPP-IV) inhibitors or any insulin) prior to informed consent (previous short term use of insulin (up to two weeks) is allowed if taken at least 8 weeks prior informed consent)
- treatment with any anti-obesity drug less than 3 months before ICF
- uncontrolled hyperglycemia
- previous or planned bariatric surgery or intervention
- current or planned system corticoid treatment
- change in thyroid hormones treatment
- acute liver disease or impaired hepatic function
- pre-planned coronary artery revascularization within 6 months of ICF
- known hypersensitivity to any of the components
- Inappropriateness of glimepiride treatment for renal safety issues according to local prescribing information
- congestive heart failure class III or IV
- acute or chronic metabolic acidosis
- hereditary galactose intolerance
- alcohol or drug abuse
- +5 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Boehringer Ingelheimlead
- Eli Lilly and Companycollaborator
Study Sites (613)
North Alabama Research Center, LLC
Athens, Alabama, 35611, United States
Alabama Internal Medicine, PC
Birmingham, Alabama, 35235, United States
Cahaba Research, Inc.
Birmingham, Alabama, 35242, United States
Internal Medicine Center, LLC
Mobile, Alabama, 36608, United States
Diagnostic and Medical Clinic
Mobile, Alabama, 36695, United States
Extended Arm Physicians, Inc.
Montgomery, Alabama, 36106, United States
Office of Dr. Terence T. Hart MD
Tuscumbia, Alabama, 35674, United States
Advanced Clinical Research
Pell City, Alaska, 35128, United States
Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
Mesa, Arizona, 85203, United States
Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
Mesa, Arizona, 85213, United States
Genova Clinical Research
Tucson, Arizona, 85704, United States
Quality of Life Medical & Research Center
Tucson, Arizona, 85712, United States
Northeast Arkansas Baptist Clinic
Jonesboro, Arkansas, 72404, United States
Medical Investigations, Inc
Little Rock, Arkansas, 72205, United States
Aureus Research, Inc
Little Rock, Arkansas, 72211, United States
Desert Oasis Healthcare
Bermuda Dunes, California, 92203, United States
Edinger Medical Group and Research Center
Fountain Valley, California, 92708, United States
Clinical Trials of St. Jude Heritage Med. Group
Fullerton, California, 92835, United States
Long Beach Center for Clinical Research
Long Beach, California, 90807, United States
Office of Dr. Richard S. Cherlin
Los Gatos, California, 95032, United States
Providence Clinical Research
North Hollywood, California, 91606, United States
Chaparral Medical Group, Inc
Pomona, California, 91767, United States
ARI Clinical Trials, Inc
Redondo Beach, California, 90277, United States
San Diego Sports Medicine and Family Health Center
San Diego, California, 92120, United States
West Coast Research, LLC
San Ramon, California, 94582, United States
University of California Los Angeles
Sylmar, California, 91342, United States
Metabolic Institute of America
Tarzana, California, 91356, United States
Matrix Research Institute
Tustin, California, 92780, United States
Orange County Research Center
Tustin, California, 92780, United States
Westlake Medical Research
Westlake Village, California, 91361, United States
Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
Colorado Springs, Colorado, 80909, United States
Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
Colorado Springs, Colorado, 80920, United States
East Coast Medical Associates
Boca Raton, Florida, 33433, United States
Todd Kazdan, DO Family Practice
Davie, Florida, 33314, United States
Century Clinical Research, Inc
Daytona Beach, Florida, 32117, United States
Doral Research Center
Doral, Florida, 33172, United States
Riverside Clinical Research
Edgewater, Florida, 32132, United States
Alan Graff, MD, PA
Fort Lauderdale, Florida, 33309, United States
M & O Clinical Research, LLC
Fort Lauderdale, Florida, 33316, United States
Eastern Research
Hialeah, Florida, 33013, United States
Research in Miami Inc
Hialeah, Florida, 33013, United States
Jacksonville Impotence Treatment Center
Jacksonville, Florida, 32223, United States
East Coast Institute for Research, LLC
Jacksonville, Florida, 32258, United States
Care Partners Clinical Research LLC
Jacksonville, Florida, 32277, United States
Precision Clinical Research, LLC
Lauderdale Lakes, Florida, 33319, United States
Veritas Research Corporation
Miami, Florida, 33126, United States
APF Research, LLC
Miami, Florida, 33134, United States
Swiss Medical Research
Miami, Florida, 33135, United States
University of Miami
Miami, Florida, 33136, United States
South Miami Clinical Research
Miami, Florida, 33143, United States
Well Pharma Medical Research
Miami, Florida, 33143, United States
Advanced Pharma CR, LLC
Miami, Florida, 33147, United States
AppleMed Research Group, LLC
Miami, Florida, 33155, United States
Kendall South Medical Center, Inc
Miami, Florida, 33185, United States
Suncoast Clinical Research, Inc.
New Port Richey, Florida, 34652, United States
Advanced Research Institute, Inc
New Port Richey, Florida, 34653, United States
Sunshine Research Center
Opa-locka, Florida, 33054, United States
Diabetes and Endocrine Center of Orlando
Orlando, Florida, 32803, United States
Suncoast Clinical Research
Palm Harbor, Florida, 34684, United States
Misal Khan, MD FRCS, ED, PA
Panama City, Florida, 32401, United States
Iconic Clinical Trials
Pembroke Pines, Florida, 33024, United States
Gulf Region Clinical Research Institute
Pensacola, Florida, 32514, United States
St. John's Center for Clinical Research
Ponte Vedra Beach, Florida, 32081, United States
Metabolic Research Institute
West Palm Beach, Florida, 33401, United States
PMI Health Research Group
Atlanta, Georgia, 30312, United States
Atlanta Diabetes Associates
Atlanta, Georgia, 30318, United States
Albert F. Johary MD, PC
Dunwoody, Georgia, 30338, United States
Georgia Clinical Research, LLC
Snellville, Georgia, 30078, United States
Hayden Lake Family Physicians
Hayden Lake, Idaho, 83835, United States
Boise Kidney and Hypertension Institute
Meridian, Idaho, 83642, United States
Suburban Clinical Research
Bolingbrook, Illinois, 60490, United States
Cedar-Crosse Research Center
Chicago, Illinois, 60607, United States
John H. Stroger Jr. Hospital of Cook Country
Chicago, Illinois, 60612, United States
Apex Medical Research
Chicago, Illinois, 60616, United States
Pharmakon Inc
Evergreen Park, Illinois, 60805, United States
American Health Network
Avon, Indiana, 46123, United States
Investigators Research Group, LLC
Brownsburg, Indiana, 46112, United States
American Health Network of Indiana, LLC
Franklin, Indiana, 46131, United States
Mapleton Medical Center
Indianapolis, Indiana, 46205, United States
American Health Network, LLC
Indianapolis, Indiana, 46254, United States
McKinley Research, LLC
Mishawaka, Indiana, 46545, United States
American Health Network of Indiana, LLC
Muncie, Indiana, 47304, United States
MCM Clinical Research, LLC
Florence, Kentucky, 41042, United States
Kentucky Diabetes Endocrinology Center
Lexington, Kentucky, 40503, United States
Four Rivers Clinical Research, Inc
Paducah, Kentucky, 42003, United States
Crescent City Clinical Research
Metairie, Louisiana, 70006, United States
Acadia Clinical Research, LLC
Bangor, Maine, 04401, United States
Office of Dr. Stephen R. Smith, MD
Baltimore, Maryland, 21234, United States
Endocrine and Metabolic Consultants
Rockville, Maryland, 20852, United States
Tristan Medical Enterprises, PC dba Regeneris
North Attleboro, Massachusetts, 02760, United States
ClinSite, LLC
Canton, Michigan, 48187, United States
Apex Medical Research, AMR Inc
Flint, Michigan, 48504, United States
Westside Family Medical Center, PC
Kalamazoo, Michigan, 49009, United States
Tri City Medical Centers, PC
Livonia, Michigan, 48152, United States
KMED Research
Saint Clair Shores, Michigan, 48081, United States
Tri-County Research, Inc
Sterling Heights, Michigan, 48310, United States
Medical Research Associates
Traverse City, Michigan, 49684, United States
Oakland Medical Research Center
Troy, Michigan, 48085, United States
Park Nicollet Institute
Minneapolis, Minnesota, 55416, United States
The Center for Clinical Trials, Inc.
Biloxi, Mississippi, 39531, United States
Mercy Health Research
St Louis, Missouri, 63141, United States
Quality Clinical Research
Omaha, Nebraska, 68114, United States
Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC
Henderson, Nevada, 89052, United States
Clinical Research of South Nevada
Las Vegas, Nevada, 89121, United States
Palm Medical Research Center
Las Vegas, Nevada, 89148, United States
Atco Medical Associates, PC
Atco, New Jersey, 08004, United States
Summit Medical Group
Clifton, New Jersey, 07012, United States
USMA Clinical Research
Elizabeth, New Jersey, 07201, United States
Central Jersey Medical Research
Elizabeth, New Jersey, 07202, United States
Albany Medical Center / Albany Medical College
Albany, New York, 12206, United States
Endocrine Associates of Long Island, PC
Smithtown, New York, 11787, United States
Southgate Medical Group/ Southgate Medical Park
West Seneca, New York, 14224, United States
OnSite Clinical Solutions, LLC
Asheville, North Carolina, 28801, United States
Kernodle Clinic West
Burlington, North Carolina, 27215, United States
The University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27517, United States
Internal Medicine Research
Charlotte, North Carolina, 28204, United States
Gaffney Health Services
Charlotte, North Carolina, 28205, United States
Durham Internal Medicine Associates
Durham, North Carolina, 27704, United States
Sentara Family Medicine
Elizabeth City, North Carolina, 27909, United States
PMG Research of Raleigh, LLC
Raleigh, North Carolina, 27609, United States
Carolina Research Center, Inc
Shelby, North Carolina, 28150, United States
Piedmont Healthcare
Statesville, North Carolina, 28625, United States
PMG Research of Wilmington, LLC
Wilmington, North Carolina, 28401, United States
Community Health Care of Manchester
Akron, Ohio, 44319, United States
Community Medical Associates, LLC
Austintown, Ohio, 44515, United States
Harrison Community Research Center
Cadiz, Ohio, 43907, United States
Medical Frontiers, LLC
Carlisle, Ohio, 45005, United States
Genoa Medical Center
Genoa, Ohio, 43430, United States
Office of Dr. Craig S. Thompson, MD, LLC
Marion, Ohio, 43302, United States
RAS Health Limited
Marion, Ohio, 43302, United States
Advanced Medical Research, LLC
Maumee, Ohio, 43537, United States
Pharmacotherapy Research Associates, Inc
Zanesville, Ohio, 43701, United States
Infinity Research Group, LLC
Oklahoma City, Oklahoma, 73103, United States
Castlerock Clinical Research Consultants, LLC
Tulsa, Oklahoma, 74136, United States
Oregon Medical Group
Eugene, Oregon, 97401, United States
Harleysville Medical Associates
Harleysville, Pennsylvania, 19438, United States
Detweiler Family Medicine & Associates, PC
Lansdale, Pennsylvania, 19446, United States
Temple University School of Medicine
Philadelphia, Pennsylvania, 19140, United States
Warminster Medical Associates, PC
Warminster, Pennsylvania, 18974, United States
New England Center for Clinical Research, Inc
Cranston, Rhode Island, 02920, United States
Hartwell Research Group, LLC
Anderson, South Carolina, 29621, United States
Paris View Family Practice
Greenville, South Carolina, 29601, United States
Mountain View Clinical Research
Greer, South Carolina, 29651, United States
South Carolina Nephrology and Hypertension Center, Inc
Orangeburg, South Carolina, 29118, United States
Carolina Diabetes & Kidney Center
Sumter, South Carolina, 29150, United States
PMG Research of Bristol
Bristol, Tennessee, 37620, United States
University Diabetes and Endocrine Consultants
Chattanooga, Tennessee, 37411, United States
University of Tennessee
Memphis, Tennessee, 38163, United States
Trinity Clinical Research, LLC
Tullahoma, Tennessee, 37388, United States
KRK Medical Research
Arlington, Texas, 76012, United States
Austin Center for Clinical Research
Austin, Texas, 78758, United States
Punzi Medical Center
Carrollton, Texas, 75006, United States
Dallas Diabetes and Endocrine Center
Dallas, Texas, 75230, United States
Baylor Endocrine Center
Dallas, Texas, 75246, United States
University of Texas Southwestern Medical Center
Dallas, Texas, 75390-8858, United States
Jacon Medical Research Associates, LLC
Houston, Texas, 77030, United States
JVC Family Medicine
Houston, Texas, 77040, United States
Clinical Trial Network
Houston, Texas, 77074, United States
Endocrine and Psychiastry Center
Houston, Texas, 77095, United States
Pioneer Research Solutions, Inc.
Houston, Texas, 77099, United States
Midland Clinical Research Center
Midland, Texas, 79707, United States
Hill Country Medical Associates
New Braunfels, Texas, 78130, United States
Naidu Clinic
Odessa, Texas, 79761, United States
The Methodist Hospital d/b/a HMRI CCAT at Pearland
Pearland, Texas, 77584, United States
Village Health Partners
Plano, Texas, 75024, United States
Sun Research Institute
San Antonio, Texas, 78215, United States
Northeast Clinical Research of San Antonio, LLC
Schertz, Texas, 78154, United States
Kenneth Otah and Associates
Sugar Land, Texas, 77478, United States
PHS Clinical Trials
Midvale, Utah, 84047, United States
Highland Clinical Research
Salt Lake City, Utah, 84124, United States
Burke Internal Medicine and Research
Burke, Virginia, 22015, United States
Ettrick Health Center
Ettrick, Virginia, 23803, United States
Manassas Clinical Research Center
Manassas, Virginia, 20110, United States
Clinical Research Partners, LLC
Richmond, Virginia, 23220, United States
Richmond Family Practice
Richmond, Virginia, 23220, United States
Larry D Stonesifer, MD Inc., PS
Federal Way, Washington, 98003, United States
Premier Clinical Research
Spokane, Washington, 99204, United States
Instituto de Investigaciones Clínicas de Bahía Blanca
Bahía Blanca, B8000FTD, Argentina
CIPREC
CABA, C1119ACN, Argentina
CENUDIAB
CABA, C1440AAD, Argentina
Instituto Médico Especializado
Capital Federal, C1405BCH, Argentina
Consultorios Asociados de Endocrinología e Invest Clínica
Capital Federal, C1425AGC, Argentina
Instituto Cardiovascular de Corrientes Juana Francisca Cabra
Corrientes, W3400AMZ, Argentina
Ilaim-Ceom
Córdoba, X5000BNB, Argentina
IPAC - Clínica Privada Caraffa SRL
Córdoba, X5008KKF, Argentina
Hospital Italiano de La Plata
La Plata, B1900AWT, Argentina
CIPADI
Mendoza, M5500EVJ, Argentina
Instituto de Investigaciones Clinicas de Rosario
Rosario, S2000CVD, Argentina
Instituto de Hematología y Medicina Clínica Dr. Rubén Davoli
Rosario, S2000CXP, Argentina
Hospital San Bernardo
Salta, A4406CLA, Argentina
Investigaciones Clinicas Tucuman
San Miguel de Tucumán, T4000ICL, Argentina
Instituto de Investigaciones Biomédicas
Santa Fe, S3000FNF, Argentina
Centro de Investigaciones Clínicas del Litoral
Santa Fe, S3000SWO, Argentina
Royal Brisbane & Women's Hospital-Endocrinology
Herston, Queensland, 4029, Australia
Logan Hospital
Meadowbrook, Queensland, 4131, Australia
Royal Adelaide Hospital
Adelaide, South Australia, 5000, Australia
Eastern Clinical Research Unit
East Ringwood, Victoria, 3135, Australia
Royal Melbourne Hospital
Parkville, Victoria, 3050, Australia
Blankenberge - PRAC Vileyn, Geert
Blankenberge, 8370, Belgium
Bonheiden - HOSP Imelda
Bonheiden, 2820, Belgium
De Pinte - PRAC Hollanders, Geert
De Pinte, 9840, Belgium
Retie - PRAC De Vos, Axel
Dessel, 2480, Belgium
Deurne - PRAC Heyvaert, Frank
Deurne, 2100, Belgium
Deurne - PRAC Verelst, Joost
Deurne, 2100, Belgium
Genk - PRAC Vernijns, J.
Genk, 3600, Belgium
Gozée - PRAC De Meulemeester, Marc
Gozée, 6534, Belgium
Hasselt - PRAC Vantroyen, Daniel
Hasselt, 3500, Belgium
Herent - PRAC Denolf, Bart
Herent, 3020, Belgium
Linkebeek - PRAC Maury, Olivier
Linkebeek, 1630, Belgium
Moorsel - PRAC Van Mulders, N.
Moorsel, 9310, Belgium
Natoye - PRAC Balthazar, Y.
Natoye, 5360, Belgium
Tremelo - PRAC Vermeersch, Lode
Tremelo, 3210, Belgium
Hospital Universitário João de Barros Barreto
Belém, 66073-000, Brazil
Universidade Federal do Paraná
Curitiba, 80060-900, Brazil
Hospital Geral de Goiânia Alberto Rassi
Goiânia, 74043-110, Brazil
Centro de Pesquisas Clínicas Ltda
Higienópolis, 01244-030, Brazil
Centro de Estudos em Diabetes e Hipertensão
Joaquim Távora, 60115-282, Brazil
Irmandade Santa Casa de Misericordia de Porto Alegre
Porto Alegre, 90020-090, Brazil
Centro de Pesquisas em Diabetes
Porto Alegre, 90035-170, Brazil
Instituto Estadual de Diabetes e Endocrinologia
Rio de Janeiro, 20211-340, Brazil
Irmandade da Santa Casa de Misericórdia de São Paulo - IPEC - Instituto de Pesquisa Clínica
Santa Cecília, 01221-020, Brazil
Instituto de Molestias Cardiovasculares - IMC
São José do Rio Preto, 15015-210, Brazil
Hospital das Clinicas da FMUSP
São Paulo, 05403-900, Brazil
Hospital do Rim e Hipertensão - UNIFESP
Vila Clementino, 04025-011, Brazil
Univ.Multiprofile Hospital "Dr. Georgy Stranski" EAD, Pleven
Pleven, 5800, Bulgaria
Multiprofile Hospital for Active Treatment
Sofia, 1431, Bulgaria
Multiprofile Hospital for Active Treatment "Zaritza Johanna"
Sofia, 1527, Bulgaria
Military Medical Academy, Clin. Endocrinology & Metab. Dis.
Sofia, 1606, Bulgaria
MHAT Prof Stoyan Kirkovich AD
Stara Zagora, 6000, Bulgaria
IUCPQ (Laval University)
Québec, Migration Data, G1V 4G5, Canada
First Line Medical Services Ltd.
St. John's, Newfoundland and Labrador, A1E 2C2, Canada
Topsail Road Medical Clinic
St. John's, Newfoundland and Labrador, A1E 2E2, Canada
Cambridge Cardiac Care Inc.
Cambridge, Ontario, N1R 6V6, Canada
Hamilton Medical Research Group
Hamilton, Ontario, L8M 1K7, Canada
SKDS Research Incorporated
Newmarket, Ontario, L3Y 5G8, Canada
Wilderman Medical Clinic
Thornhill, Ontario, L4J 1W3, Canada
St. Michael's Hospital
Toronto, Ontario, M5C 2T2, Canada
Albion Finch Medical Centre
Toronto, Ontario, M9V 4B4, Canada
Kings County Medical Centre
Montague, Prince Edward Island, C0A 1R0, Canada
Dynamik Research
Pointe-Claire, Quebec, H9R 3J1, Canada
Consulta Privada Maria Loreto Aguirre Coveña
Providencia, 7500010, Chile
Hospital de Servicios Médicos Godoy Ltda
Providencia, Chile
Centro Medico Antulawen
Temuco, Chile
Hospital Naval Almirante Nef
Viña del Mar, Chile
BioMelab
Barranquilla, Colombia
Centro Cientifico Asistencial Jose Luis Accini
Barranquilla, Colombia
Fundacion del Caribe de Investigacion Biomedica
Barranquilla, Colombia
Dexa Diabetes Servicios Médicos Ltda
Bogotá, Colombia
Endocare Research Institute
Bogotá, Colombia
UNIENDO Unidad Integral de Endocrinologia
Bogotá, Colombia
Centro cardiovascular Aristides
Cartagena, Colombia
centro de Diagnostico Cardiologico para la Investigacion Bio
Cartagena, Colombia
Fundacion Cardiovascular de Colombia
El Bosque, Colombia
Fundación Oftalmologica de Santander
El Bosque, Colombia
Fundación Centro de Investigaciones Biomédicas Riescard
Tolima, Colombia
Internal & Diabetology Ambulance, Jablonec nad Nisou
Jablonec nad Nisou, 466 01, Czechia
Diabetology & Internal Ambulance
Olomouc-Lazce, 779 00, Czechia
Internal & Diabetology Ambulance Dr. Vrkoc, Ostrava
Ostrava, 702 00, Czechia
Cardiology ambulance, Plzen
Pilsen, 301 00, Czechia
Diebetology internal Ambulance
Prague, 101 00, Czechia
ResTrial s.r.o.
Prague, 181 00, Czechia
Internal & Diabetology Ambulance, Prostejov
Prostějov, 796 01, Czechia
Hospital Strakonice, Internal Department
Strakonice, 386 29, Czechia
Diabetesklinikka, Mehiläinen Töölö
Helsinki, 00260, Finland
Lääkärikeskus Ite
Joensuu, 80100, Finland
Lääkärikeskus Aava Kerava
Kerava, 04200, Finland
Kokkolan Lääkärikeskus
Kokkola, 67100, Finland
IteLasaretti
Kuopio, FI-70100, Finland
Terveystalo Oulu, Diapolis
Oulu, FI-90100, Finland
TYKS
Turku, FI-20520, Finland
CAB Hell M, MG, Behren Les Forbach
Behren-lès-Forbach, 57460, France
CAB Breton Dr Nicolas
Béziers, 34500, France
HOP Haut Levèque, Diabéto, Pessac
Bordeaux, 33075, France
CAB Lemarie B, MG, Bourg des Cptes
Bourg-des-Comptes, 35890, France
CAB Cadinot Dr D, Broglie
Broglie, 27270, France
CAB Ferrier R, MG, Cannes
Cannes, 06400, France
CAB Jordan E, MG, Carbonne
Carbonne, 31390, France
CAB Merlin P, MG Castets
Castets, 40260, France
CAB Fonteny R, MG, Chartres
Chartres, 28000, France
CAB Fournier P, MG, Chartres
Chartres, 28000, France
CAB Martocq G, MG, Cournonterral
Cournonterral, 34660, France
HOP, Fort de France, Fort de France
Fort de France, 97261, France
CAB Le Mouel S, MG, Hinx
Hinx, 40180, France
CAB Pholsena, MG, La Réunion
La Réunion, 97410, France
CAB Bismuth M
Labarthe-sur-Lèze, 31860, France
CAB Zimmermann D
Louvigne de Bie, 35680, France
CAB Mainetti P, MG, Maintenon
Maintenon, 28130, France
CAB Barucq F, MG, Orthez
Orthez, 64300, France
CAB Mostephai M
Orthez, 64300, France
CAB Cassagnes JL, MG, Palau Del Vidre
Palau-del-Vidre, 66690, France
CAB Mercey Y, MG, St Genies des Fontaines
Saint Genies Des Fontaines, 66740, France
Hop St Dié des Vosges, Diabéto, St Dié des Vosges
Saint-Dié, 88187, France
CAB Bonneau D, MG, Thouars
Thouars, 79100, France
CAB Morel H, MG, Tilly sur Seulles
Tilly-sur-Seulles, 14250, France
Unimed Ajara LLC, Private Practice
Batumi, 6004, Georgia
Central Hospital LTD 'Gormedi', Gori
Gori, 1400, Georgia
L&J Clinic, Kutaisi
Kutaisi, 4600, Georgia
EC Cardiology Clinic,Tbilisi
Tbilisi, 0144, Georgia
National Center for Diabetes Research Ltd., Tbilisi
Tbilisi, 0159, Georgia
National Institute of Endocrinology, Tbilisi
Tbilisi, 0159, Georgia
Zhordania Institute of Human Reproduction, Tbilisi
Tbilisi, 0159, Georgia
Medical Centre Medelite Ltd., Tbilisi
Tbilisi, 0177, Georgia
Chemotherapy & Immunotherapy Clinic 'Medulla', Tbilisi
Tbilisi, 0186, Georgia
JSC 'Curatio'
Zugdidi, 2100, Georgia
Universitätsklinikum Aachen, AöR
Aachen, 52074, Germany
Studienzentrum Klausmann
Aschaffenburg, 63739, Germany
Gemeinschaftspraxis, Asslar
Aßlar, 35614, Germany
Diabetes Schwerpunktpraxis
Bad Nauheim, 61231, Germany
Praxis Dr. Naumburger, Berlin
Berlin, 10409, Germany
emovis GmbH
Berlin, 10629, Germany
Praxis Dr. Rieker, Berlin
Berlin, 10789, Germany
IFG Institut für Gesundheitsförderung GmbH
Berlin, 12621, Germany
Dünnwaldpraxis, Köln
Cologne, 51069, Germany
MVZ DaVita Dormagen GmbH
Dormagen- Hackenbroich, 41540, Germany
Praxis Dr. Busch, Dortmund
Dortmund, 44137, Germany
GWT-TUD GmbH
Dresden, 01307, Germany
Praxis Dr. Schlecht, Eisenach
Eisenach, 99817, Germany
ZKS Südbrandenburg GmbH
Elsterwerda, 04910, Germany
Praxis Dr. Huptas, Essen
Essen, 45307, Germany
Praxis Dr. Schmidt, Flörsheim
Flörsheim, 65439, Germany
Institut für Stoffwechselforschung, Frankfurt
Frankfurt, 60322, Germany
Praxis Dr. Groeneveld, Furth im Wald
Furth im Wald, 93437, Germany
Praxis Dr. Kohlhas, Gebhardshain
Gebhardshain, 57580, Germany
Praxis Dr. Samer, Haag
Haag, 83527, Germany
Klinische Forschung Management & Services GmbH
Hamburg, 20253, Germany
Diabetologische Schwerpunktpraxis
Hamburg, 21073, Germany
Praxis Dr. Burkhardt, Hamburg
Hamburg, 22335, Germany
Diabeteszentrum Alstertal, Hamburg
Hamburg, 22391, Germany
Praxis Dr. Herrmann, Hatten
Kirchhatten, 26209, Germany
Praxis Dr. Klein, Künzing
Künzing, 94550, Germany
Praxis Dr. Nischik, Leipzig
Leipzig, 04109, Germany
Praxis Dr. Kropp, Lübeck
Lübeck, 23554, Germany
PFÜTZNER Science & Health Institute GmbH
Mainz, 55128, Germany
Diabetologische Schwerpunktpraxis
Münster, 48153, Germany
Praxis Dr. Böckmann
Neumünster, 24534, Germany
Praxis Dr. Hilgenberg
Rehburg-Loccum, 31547, Germany
Praxis Dr. Naudts, Rodgau
Rodgau/Dudenhofen, 63110, Germany
Praxis Dr. Hirschhäuser
Saarbrücken, 66121, Germany
Praxis Dr. Segner, St. Ingberg
Saint Ingbert / Oberwürzbach, 66386, Germany
Praxis Dr. Herrmann
Schwabenheim, 55270, Germany
Praxis Dr. Dietlein
Stadtbergen, 86391, Germany
Praxis Dr. Sauter
Wangen, 88239, Germany
Schwerpunktpraxis Diabetologie
Zwenkau, 04442, Germany
General Hospital of Athens Evangelismos
Athens, 10676, Greece
General University Hospital "Attikon"
Haidari, Athens, 12410, Greece
Univ. Gen. Hosp. of Ioannina
Ioannina, 45500, Greece
General Hospital "Amalia Fleming"
Melissia, Athens, 15127, Greece
General Hospital of Nikaia
Nikaia, 18484, Greece
University General Hospital of Thessaloniki AHEPA
Thessaloniki, 54636, Greece
General Hopsital of Thessaloniki "Ippokrateio"
Thessaloniki, 54642, Greece
Kliniki Thermi
Thessaloniki, 57001, Greece
Alice Ho Miu Ling Nethersole Hospital
Hong Kong, Hong Kong
Prince of Wales Hospital
Hong Kong, Hong Kong
Queen Mary Hospital
Hong Kong, Hong Kong
Imre Magyar Hospital, Ajka
Ajka, 8400, Hungary
Lausmed Kft. Outpatient Unit of Internal Medicine
Baja, 6500, Hungary
Karolyi Sandor Hospital, Budapest
Budapest, 1041, Hungary
Bekes County Pandy Kalman Hospital
Gyula, 5700, Hungary
Erzsebet Hospital, Hodmezövasarhely
Hódmezövásárhely, 6800, Hungary
Dr. Samuel Diosszilagyi Hospital and Outpatient Clinic, Mako
Makó, 6900, Hungary
TaNa Med Kft.
Mosonmagyaróvár, 9200, Hungary
Grof Esterhazy Hospital and Outpatient Clinic
Pápa, 8500, Hungary
Tolna County Balassa Janos Hospital
Szekszárd, 7100, Hungary
Shree Krishna Hospital and Heart Care Centre, Ahmedabad
Ahmedabad, 380052, India
CIIGMA Institute of Medical Sciences Pvt Ltd
Aurangabad, 431001, India
Diabetes care and research centre
Bangalore, 560010, India
Manipal Hospital
Bangalore, 560017, India
Bangalore Diabetes Centre (BDC)- Medisys Clinical Research
Bangalore, 560043, India
MS Ramaiah Memorial Hospital,
Bangalore, Karnataka, 560054, India
Belgaum Diabetes Centre, Belgaum
Belagavi, 590001, India
Swamy Diabetes Centre
Chennai, 600 028, India
Apollo Hospitals
Chennai, 600010, India
M V Hospital For Diabetes and Diabetes Research Centre
Chennai, 600013, India
Dr. Mohans Diabetes Speciality Centre
Chennai, 600086, India
Kovai Diabetes Speciality Centre & Hospital
Coimbatore, 641009, India
TOTALL Diabetes Hormone Institute
Indore, 452010, India
Diabetes Thyroid and Endocrine Centre
Jaipur, 302 006, India
Diamed Clinical Research Services Pvt. Ltd.
Jaipur, 302016, India
Grant Medical Foundation, Ruby Hall Clinic
Maharashtra, 411001, India
Global Hospital- Superspeciality & Transplant Centre
Mumbai, 400012, India
RHIDEM
Mumbai, 400014, India
K.G.N. Diabetes and Endocrine Centre
Mumbai, Maharastra, 400008, India
Sunil's Diabetes care and Research Centre
Nagpur, 440 010, India
Jahingir Clinical Development Centre
Pune, 411001, India
Deshmukh Clinic
Pune, 411030, India
Diabetes Care Center
Thiruvananthapuram, 695 010, India
Yalamanchi Hospitals & Research Centres Pvt Ltd.
Vijayawada, 520 002, India
The Red House Family Practice
Co. Cork, CORK, Ireland
Connolly Hospital Blanchardstown
Dublin, 15, Ireland
The Palms GP Surgery
Gorey, Wexford, Ireland
Fethard-on-Sea Medical Practice
Wexford, Wexford, Ireland
Barzilai Medical Center
Ashkelon, 78278, Israel
Rambam Medical Center
Haifa, 31096, Israel
Edith Wolfson Medical Center, Diabetic Unit, Holon
Holon, 58100, Israel
Hadassah Medical Center, Ein-Karem
Jerusalem, 91120, Israel
Western Galilee Hospital
Nahariya, 22100, Israel
Sourasky Medical Center
Tel Aviv, 64239, Israel
The Chaim Sheba Medical Center Tel Hashomer
Tel Litwinsky, 52621, Israel
Ospedale "SS. Trinità"
Cagliari, 09100, Italy
Policlinico Universitario Mater Domini, Universita di Catanzaro
Catanzaro, 88100, Italy
Policlinico San Martino
Genova, 16132, Italy
Ospedale di Guastalla
Guastalla (RE), 42016, Italy
A.O.U.Policlinico G.Martino
Messina, 98125, Italy
Fondazione Centro San Raffaele del Monte Tabor
Milan, 20132, Italy
Ospedale S. Pertini
Roma, 00100, Italy
Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
Roma, 00189, Italy
IRCCS Gruppo Multimedica
Sesto San Giovanni (MI), 20099, Italy
Daishinkai Medical Corporation Ookuma Hospital
Aichi, Nagoya, 462-0825, Japan
Chibanishi General Hospital
Chiba, Matsudo, 270-2251, Japan
New Tokyo Heart Clinic
Chiba, Matsudo, 271-0077, Japan
Kashinoki I.M. Clinic, Fukushima, I.M.
Fukushima, Date, 960-0418, Japan
Japan Community Health care Organization Nihonmatsu Hospital
Fukushima, Nihonmatsu, 964-8501, Japan
Iwase General Hospital
Fukushima, Sukagawa, 962-8503, Japan
Iryohojinshadan Sasaki Clinic
Hyogo, Amagasaki, 660-0827, Japan
Takasagoseibu Hospital
Hyogo, Takasago, 676-0812, Japan
Kanagawa Cardiovascular and Respiratory Center
Kanagawa, Yokohama, 236-0051, Japan
Jinnouchi Clinic Diabetes Care Center
Kumamoto, Kumamoto, 862-0976, Japan
Kumamoto Rosai Hospital
Kumamoto, Yatsushiro, 866-8533, Japan
Koga General Hospital
Miyazaki, Miyazaki, 880-0041, Japan
Saitama Medical Cooperative Association Hanyu General Hospital
Saitama, Hanyu, 348-0045, Japan
Nihon University Itabashi Hospital
Tokyo, Itabashi-ku, 173-8610, Japan
Penang Medical College
George Town, 10450, Malaysia
Monash University
Johor Bahru, Johor, 80100, Malaysia
Hospital University Sains Malaysia
Kota Bharu, 16150, Malaysia
Hospital Kuala Lumpur
Kuala Lumpur, 50586, Malaysia
University Malaya Medical Centre
Kuala Lumpur, 59100, Malaysia
Hospital Tengku Ampuan Afzan
Kuantan, 25100, Malaysia
Hospital Melaka
Malacca, 75400, Malaysia
Hospital Taiping
Taiping, 34000, Malaysia
Hospital General de Acapulco
Acapulco, 39570, Mexico
Centro de Investigacion Cardiometabolica de Aguascalientes
Aguascalientes, 20234, Mexico
Instituto Nacional de Cardiologia Ignacio Chavez
Distrito Federal, 14080, Mexico
Unidad de Investigacion Clinica Cardiometabolica de Occident
Guadalajara, 44150, Mexico
Hospital Universitario Dr Jose Eleuterio Gonzalez
Monterrey, 64460, Mexico
Huisartspraktijk Emmers
's-Hertogenbosch, 5235 KG, Netherlands
FlevoResearch
Almere Stad, 1311 RL, Netherlands
Academisch Medisch Centrum (AMC)
Amsterdam, 1105 AZ, Netherlands
Rode Kruis Ziekenhuis Beverwijk
Beverwijk, 1942 LE, Netherlands
Andromed Breda
Breda, 4811 SW, Netherlands
Noordwest Ziekenhuisgroep, location Den Helder
Den Helder, 1782 GZ, Netherlands
Andromed Eindhoven
Eindhoven, 5611 NV, Netherlands
Andromed Noord
Groningen, 9711 SG, Netherlands
Vasculair Onderzoek Centrum
Hoorn, 1624 NP, Netherlands
Maastricht Universitair Medisch Centrum
Maastricht, 6229 HX, Netherlands
Andromed Rotterdam
Rotterdam, 3039 BD, Netherlands
Rotterdam Research Institute
Rotterdam, 3039 BD, Netherlands
Ikazia Ziekenhuis
Rotterdam, 3083 AN, Netherlands
Antonius Ziekenhuis
Sneek, 8601 ZK, Netherlands
Andromed Oost
Velp, 6883 ES, Netherlands
Andromed Leiden-Zoetermeer
Zoetermeer, 2724 EK, Netherlands
Christchurch Hospital
Christchurch, 4710, New Zealand
RMC Medical Research Ltd
Dunedin, 9012, New Zealand
P3 Research, Wellington
Newtown Wellington NZ, 6021, New Zealand
P3 Research, Promed House
Tauranga, 3110, New Zealand
Medi 3 AS
Ålesund, N-6002, Norway
Bodø Legesenter AS, avd. for med. studier
Bodø, N-8001, Norway
Medi 3 Innlandet AS, avd Elverum
Elverum, N-2408, Norway
Vestre Viken HF, Bærum sykehus
Gjettum, N-1346, Norway
M3 Helse AS
Hamar, N-2317, Norway
Bylegene SA
Jessheim, N-2050, Norway
Heiaklinikken
Lierskogen, N-3420, Norway
Rådhuset Spesialistsenter
Oslo, N-0160, Norway
Sandvika Spesialistsenter
Sandvika, N-1337, Norway
Grålum Legesenter
Sarpsborg, N-1727, Norway
Forusakutten - Kolibri Medical, Avd. Stavanger
Stavanger, N-4005, Norway
Instituto Delgado de Investigacion Medica
Arequipa, LIMA 54, Peru
Clinica San Pedro
Huacho, Peru
Hospital Nacional Dos de Mayo
Lima, 01, Peru
Clinica Internacional
Lima, LIMA 1, Peru
Centro de Investigaciones Médicas METABOLICARE SAC
Lima, Lima 27, Peru
Clinica San Gabriel
Lima, Lima 32, Peru
Centro De Especialidades Medicas Santa Maria S.A.C
Piura, Peru
Clinica San Judas Tadeo
San Miguel, 32, Peru
Asian Hospital & Medical Center
City of Muntinlupa, 1781, Philippines
Center for Diabetes Care
Iloilo City, 5000, Philippines
Mary Mediatrix Medical Center
Lipa City, Batangas, 4217, Philippines
Philippine General Hospital
Manila, 1000, Philippines
University of Santo Tomas Hospital
Manila, 1008, Philippines
Manila Doctors Hospital
Manila, 1011, Philippines
St. Luke's Medical Center
Quezon City, 1102, Philippines
Quirino Memorial Medical Center
Quezon City, 1109, Philippines
Cardinal Santos Medical Center
San Juan City, 1503, Philippines
Surigao Health Specialists
Surigao City, 8400, Philippines
Hospital Fernando Fonseca, EPE
Amadora, 2700-276, Portugal
CHLO, EPE - Hospital de Santa Cruz
Carnaxide, 2799-523, Portugal
CHUC - Centro Hospitalar e Universitário de Coimbra, EPE
Coimbra, 3000-075, Portugal
Centro Hospitalar da Cova da Beira Hospital Pêro da Covilhã
Covilha, 6200-251, Portugal
Hospital Distrital Figueira da Foz, EPE
Figueira da Foz Municipality, 3094-001, Portugal
Hospital da Luz
Lisbon, 1500-650, Portugal
Centro Hospitalar São João,EPE
Porto, 4202-451, Portugal
Centro Hospitalar de Entre o Douro e Vouga, E.P.E. - Hospital de São Sebastião
Santa Maria da Feira, 4520-211, Portugal
SC Diabol SRL, Brasov
Brasov, 500365, Romania
Nicodiab SRL, Bucharest
Bucharest, 010507, Romania
SC Medical Centre "Sanatatea Ta" SRL, Bucharest
Bucharest, 020614, Romania
Consultmed SRL, Iasi
Iași, 700547, Romania
Emergency County Clinical Hospital, Sibiu
Sibiu, 550245, Romania
Private Practice Dr. Remus Gagiu
Târgovişte, 130083, Romania
LLC Clinic of new technologies of medicine
Dzerzhinsky, 140091, Russia
City Clinical Hospital No. 6 of MoH of Udmurt Republic
Izhevsk, 436000, Russia
City Clinical Hospital No. 4, Moscow
Moscow, 115093, Russia
City Clinical Hospital No. 13, Moscow
Moscow, 115280, Russia
State Institution "Central Clinical Hospital of RAS", Moscow
Moscow, 117333, Russia
City Clinical Hospital No. 61, Moscow
Moscow, 119048, Russia
State Healthcare Institution, Regional hospital #2
Rostov-on-Don, 344029, Russia
Limited Liability Company "CENTER DIABET", Samara
Samara, 443067, Russia
MMU City Outpatient Clinic no. 20, Saratov
Saratov, 410018, Russia
Clinical Medical Center Zvezdara, Belgrade
Belgrade, 11000, Serbia
Clinical Centre Nis
Niš, 18000, Serbia
General Hospital Pancevo
Pančevo, 26000, Serbia
General Hospital Subotica, Internal Medicine
Subotica, 24000, Serbia
Clinical Hospital Center Zemun
Zemun, 11080, Serbia
DIASTYLE s.r.o., Diabetology Outpatient Department
Banská Bystrica, 974 01, Slovakia
ENDIAMED s.r.o., Dolny Kubin
Dolný Kubín, 026 01, Slovakia
CELL B s.r.o.
Levice, 934 01, Slovakia
DIA-KONTROL s.r.o.
Levice, 934 01, Slovakia
Funkystuff s.r.o., Nove Zamky
Nové Zámky, 940 01, Slovakia
Diabetologicka ambulancia MUDr. Lucia Gajdosikova s.r.o.
Považská Bystrica, 017 01, Slovakia
MEDIVASA s.r.o., Outpatient Clinic, Zilina
Žilina, 010 01, Slovakia
Dr. P. Patel
Cape Town, 7764, South Africa
Dr. E. L. Janari
Cape Town, 7965, South Africa
Dr. Vawda
Durban, 4091, South Africa
Parklands Medical Centre
Durban, 4091, South Africa
Dr. Jurgens
Krugersdorp, 1739, South Africa
Dr. H. Makan
Lenasia, 1827, South Africa
Dr. D. R. Lakha, Johannesburg
Lenasia, 2033, South Africa
Greenacres Hospital
Port Elizabeth, 6045, South Africa
Dr. M. Seeber
Pretoria, 0083, South Africa
Vergelegen Medi-Clinic
Somerset West, 7130, South Africa
Korea University Ansan Hospital
Ansan, 15355, South Korea
Inje University Busan Paik Hospital
Busan, 614-735, South Korea
Keimyung University Dongsan Medical Center
Daegu, 700-712, South Korea
National Health Insurance Service Ilsan Hospital
Goyang, 410-719, South Korea
Dongguk University Ilsan Hospital
Goyang, 410-773, South Korea
Inje University Ilsan Paik Hospital
Goyang, 411-706, South Korea
Chonbuk National University Hospital
Jeonju, 561-712, South Korea
Pusan National Univ. Hosp
Pusan, 602-739, South Korea
Seoul National University Bundang Hospital
Seongnam, 463-707, South Korea
Korea University Anam Hospital
Seoul, 02841, South Korea
Korea University Guro Hospital
Seoul, 08308, South Korea
Kangdong Sacred Heart Hospital
Seoul, 134-701, South Korea
Ajou University Hospital
Suwon, 443-380, South Korea
Wonju Severance Christian Hosp
Wŏnju, 220-701, South Korea
Pusan National University Yangsan Hospital
Yangsan, 626-770, South Korea
C.A.P. Sardenya
Barcelona, 08025, Spain
CAP Les Corts
Barcelona, 08028, Spain
CAP Casanova
Barcelona, 08036, Spain
CAP Burjassot 1
Burjassot, 46100, Spain
C.S. Natahoyo
Gijón, 33212, Spain
Hospital Universitari de Girona Doctor Josep Trueta
Girona, 17007, Spain
CAP Florida
L'Hospitalet de Llobregat, 08905, Spain
Hospital de Bellvitge
L'Hospitalet de Llobregat, 08907, Spain
CAP La Roca
La Roca Del Vallés (Barcelona), 08430, Spain
Hospital General Universitario Gregorio Marañón
Madrid, 28007, Spain
C.S. El Cristo
Oviedo, 33006, Spain
C.S. Colloto
Oviedo, 33010, Spain
C.S. Vallobin-La Florida
Oviedo, 33012, Spain
ABS Pineda de Mar
Pineda de Mar, 08397, Spain
Hospital de l'Esperit Sant
Santa Coloma de Gramanet, 08923, Spain
CAP Tàrrega
Tàrrega, 25300, Spain
CS Ingeniero Joaquin Benlloch
Valencia, 46006, Spain
Hospital Clínico de Valencia
Valencia, 46010, Spain
CTC Sahlgrenska Universitetssjukhuset
Gothenburg, 413 45, Sweden
Sjukhuset, Härnösand
Härnösand, 87182, Sweden
Avonova Hälsa AB
Järfälla, 177 30, Sweden
Skånes universitetssjukhus, Malmö
Malmo, 20502, Sweden
Dalecarlia Clinical Research Center
Rättvik, 795 30, Sweden
Södra Dalarnas vårdcentral, Hedemora
Rättvik, 79530, Sweden
Näsets Läkargrupp
Skanör, 239 33, Sweden
Vårdcentralen Silentzvägen
Uddevalla, 451 50, Sweden
S3 Clinical Research Centers
Vällingby, 162 68, Sweden
Allgemeine Medizin
Basel, 4057, Switzerland
FMH endocrinologia diabetologia
Bellinzona, 6500, Switzerland
Inselspital Bern
Bern, 3010, Switzerland
Dr. Pietro Gerber
Lugano, 6900, Switzerland
Chang-Hua Christian Hospital
Changhua, 500, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807, Taiwan
E-Da Hospital
Kaohsiung City, 824, Taiwan
Far Eastern Memorial Hospital
New Taipei City, 220, Taiwan
China Medical University Hospital
Taichung, 40447, Taiwan
Taichung Veterans General Hospital
Taichung, 40705, Taiwan
NCKUH
Tainan, 704, Taiwan
National Taiwan University Hospital
Taipei, 100, Taiwan
Shih-Kong Wu Ho-Shu Memorial Hospital
Taipei, 111, Taiwan
Taipe Veterans General Hospital
Taipei, 11217, Taiwan
Cheng Hsin General Hospital
Taipei, 112, Taiwan
Tri-Service General Hospital
Taipei, 114, Taiwan
Cardinal Tien Hospital
Taipei, 23137, Taiwan
Taipei Medical University-Shuang Ho Hospital
Taipei, 235, Taiwan
Mackay Memorial Hospital
Taipei, 25160, Taiwan
HOP Fattouma Bourguiba, Mint, Monastir
Monastir, 5000, Tunisia
HOP Hédi Chaker, Endo, Sfax
Sfax, 3029, Tunisia
HOP Farhat Hached, Mint, Sousse
Sousse, 4000, Tunisia
HOP Habib Thameur, Mint, Tunis
Tunis, 1008, Tunisia
Donetsk Regional Clinical Hosp, Therapy Department
Donetsk, 83003, Ukraine
Ivano-Frankivsk City Central Clinical Hospital
Ivano-Frankivsk, 76000, Ukraine
City Clinical Hospital No. 27, Kharkiv
Kharkiv, 61002, Ukraine
City Clinical Hospital No. 17, Kharkov
Kharkiv, 61037, Ukraine
Clinic for Cardiology "Sertse i sudyny", Kiev
Kiev, 01032, Ukraine
City Clinical Hospital No. 1, Kiev
Kiev, 02091, Ukraine
Poliklinika #2, Kyiv
Kyiv, 02002, Ukraine
City Hospital No. 5, Lvov
Lviv, 73013, Ukraine
Odeska zaliznichna likarnya, Odessa
Odesa, 65039, Ukraine
Vinnitsia Regional Endocrinology Dispensary
Vinnitsa, 21010, Ukraine
Crouch Oak Family Practice
Addlestone, KT15 2BH, United Kingdom
Ash Vale Health Centre, Aldershot
Ash Vale, Aldershot, GU12 5BA, United Kingdom
Birmingham Heartlands Hospital
Birmingham, B9 5SS, United Kingdom
Hathaway Medical Centre
Chippenham, SN14 6GT, United Kingdom
University Hospital of North Durham
Durham, DH1 5TW, United Kingdom
St Mary's Surgery
Ely, CB7 4HF, United Kingdom
Gloucestershire Royal Hospital
Gloucester, GL1 3NN, United Kingdom
James Paget University Hospital
Great Yarmouth, NR31 6LA, United Kingdom
Morriston Hospital
Swansea, SA6 6NL, United Kingdom
Royal Cornwall Hospital
Truro, TR1 3LJ, United Kingdom
Related Publications (11)
Marx N, Kolkailah AA, Rosenstock J, Johansen OE, Cooper ME, Alexander JH, Toto RD, Wanner C, Espeland MA, Mattheus M, Schnaidt S, Perkovic V, Gollop ND, McGuire DK. Hypoglycemia and Cardiovascular Outcomes in the CARMELINA and CAROLINA Trials of Linagliptin: A Secondary Analysis of Randomized Clinical Trials. JAMA Cardiol. 2024 Feb 1;9(2):134-143. doi: 10.1001/jamacardio.2023.4602.
PMID: 38170502DERIVEDBalasubramanian P, Kernan WN, Sheth KN, Ofstad AP, Rosenstock J, Wanner C, Zinman B, Mattheus M, Marx N, Inzucchi SE. Baseline Cardiovascular Risk Factor Control in Patients With Type 2 Diabetes and Coronary Disease Versus Stroke: Secondary Analysis of Cardiovascular Outcome Trials. Stroke. 2023 Aug;54(8):2013-2021. doi: 10.1161/STROKEAHA.122.042053. Epub 2023 Jul 14.
PMID: 37449424DERIVEDDar MS, Wanner C, Marx N, Ofstad AP, Mattheus M, Kaspers S, Beg SA. Cardiovascular outcomes trial data from EMPA-REG OUTCOME, CAROLINA and CARMELINA: Assessment of a novel staging system for type 2 diabetes. Diabetes Obes Metab. 2023 May;25(5):1372-1384. doi: 10.1111/dom.14989. Epub 2023 Mar 6.
PMID: 36700391DERIVEDVerhagen C, Janssen J, Minderhoud CA, van den Berg E, Wanner C, Passera A, Johansen OE, Biessels GJ. Chronic kidney disease and cognitive decline in patients with type 2 diabetes at elevated cardiovascular risk. J Diabetes Complications. 2022 Oct;36(10):108303. doi: 10.1016/j.jdiacomp.2022.108303. Epub 2022 Aug 31.
PMID: 36116359DERIVEDVerhagen C, Janssen J, Biessels GJ, Johansen OE, Exalto LG. Females with type 2 diabetes are at higher risk for accelerated cognitive decline than males: CAROLINA-COGNITION study. Nutr Metab Cardiovasc Dis. 2022 Feb;32(2):355-364. doi: 10.1016/j.numecd.2021.10.013. Epub 2021 Oct 27.
PMID: 34895804DERIVEDBiessels GJ, Verhagen C, Janssen J, van den Berg E, Wallenstein G, Zinman B, Espeland MA, Johansen OE. Effects of linagliptin vs glimepiride on cognitive performance in type 2 diabetes: results of the randomised double-blind, active-controlled CAROLINA-COGNITION study. Diabetologia. 2021 Jun;64(6):1235-1245. doi: 10.1007/s00125-021-05393-8. Epub 2021 Feb 9.
PMID: 33559704DERIVEDRosenstock J, Kahn SE, Johansen OE, Zinman B, Espeland MA, Woerle HJ, Pfarr E, Keller A, Mattheus M, Baanstra D, Meinicke T, George JT, von Eynatten M, McGuire DK, Marx N; CAROLINA Investigators. Effect of Linagliptin vs Glimepiride on Major Adverse Cardiovascular Outcomes in Patients With Type 2 Diabetes: The CAROLINA Randomized Clinical Trial. JAMA. 2019 Sep 24;322(12):1155-1166. doi: 10.1001/jama.2019.13772.
PMID: 31536101DERIVEDJanssen J, van den Berg E, Zinman B, Espeland MA, Geijselaers SLC, Mattheus M, Johansen OE, Biessels GJ. HbA1c, Insulin Resistance, and beta-Cell Function in Relation to Cognitive Function in Type 2 Diabetes: The CAROLINA Cognition Substudy. Diabetes Care. 2019 Jan;42(1):e1-e3. doi: 10.2337/DC18-0914. No abstract available.
PMID: 30811335DERIVEDChilton R. Linagliptin versus glimepiride add-on for the long-term treatment of Type 2 diabetes mellitus. Expert Rev Endocrinol Metab. 2013 Jul;8(4):345-349. doi: 10.1586/17446651.2013.811849.
PMID: 30736150DERIVEDBiessels GJ, Janssen J, van den Berg E, Zinman B, Espeland MA, Mattheus M, Johansen OE; CAROLINA(R) investigators. Rationale and design of the CAROLINA(R) - cognition substudy: a randomised controlled trial on cognitive outcomes of linagliptin versus glimepiride in patients with type 2 diabetes mellitus. BMC Neurol. 2018 Jan 15;18(1):7. doi: 10.1186/s12883-018-1014-7.
PMID: 29334906DERIVEDMarx N, Rosenstock J, Kahn SE, Zinman B, Kastelein JJ, Lachin JM, Espeland MA, Bluhmki E, Mattheus M, Ryckaert B, Patel S, Johansen OE, Woerle HJ. Design and baseline characteristics of the CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes (CAROLINA(R)). Diab Vasc Dis Res. 2015 May;12(3):164-74. doi: 10.1177/1479164115570301. Epub 2015 Mar 15.
PMID: 25780262DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Boehringer Ingelheim, Call Center
- Organization
- Boehringer Ingelheim
Study Officials
- STUDY CHAIR
Boehringer Ingelheim
Boehringer Ingelheim
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 17, 2010
First Posted
November 18, 2010
Study Start
November 11, 2010
Primary Completion
August 21, 2018
Study Completion
August 21, 2018
Last Updated
January 7, 2020
Results First Posted
January 7, 2020
Record last verified: 2019-12