Brain Activation During Accommodation to Painful Stimulation With FMRI

NCT01242540 | Completed DMC

• 1 other identifier: PRO10020252
• Study Type: observational
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

Blood oxygen level dependant (BOLD) functional magnetic resonance imaging (FMRI) investigations of pain have provided substantial insight into the workings of the human brain. To date, however, the vast majority of studies have dealt with short painful stimulations. This work will expand the investigators knowledge of how longer stimulations are processed by comparing the activation pattern from a two minute painful stimulation with that of an 30-second painful stimulus. The investigators hypothesis that accommodation to the longer stimulation will be evident by either decreases in signal intensity in brain areas known to process pain, or by increasing activity in brain areas thought to be responsible for the modulation of painful perception.

Conditions

Pain

Keywords

Pain; Functional Magnetic Resonance Imaging

Outcome Measures

Primary Outcomes (1)

• To determine the areas of brain activity from a 2 minute long painful stimulation

  After a 2 minute long painful stimulation

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Subjects will come from the general surrounding community.

You may qualify if:

• Age 18 to 50
• Right-handed
• Male or female
• Healthy individuals not taking any medication.

You may not qualify if:

• Pregnancy
• Diagnosed with any treated or untreated medical or neurological conditions
• Using any prescription drugs, including antidepressants, pain medications, sedative medications, blood pressure medications, seizure medications, or antipsychotics. Oral contraceptives are permitted
• Using any over-the-counter medications including aspirin, Tylenol, or herbal supplements
• Using any illicit substances
• Contraindications to magnetic resonance imaging.

Sponsors & Collaborators

• University of Pittsburgh: lead

Study Sites (1)

University of Pittsburgh

Pittsburgh, Pennsylvania, 15213, United States

Location

Related Publications (4)

• Ibinson JW, Small RH, Algaze A, Roberts CJ, Clark DL, Schmalbrock P. Functional magnetic resonance imaging studies of pain: an investigation of signal decay during and across sessions. Anesthesiology. 2004 Oct;101(4):960-9. doi: 10.1097/00000542-200410000-00022.

  PMID: 15448530 BACKGROUND

• Peyron R, Laurent B, Garcia-Larrea L. Functional imaging of brain responses to pain. A review and meta-analysis (2000). Neurophysiol Clin. 2000 Oct;30(5):263-88. doi: 10.1016/s0987-7053(00)00227-6.

  PMID: 11126640 BACKGROUND

• Tracey I, Ploghaus A, Gati JS, Clare S, Smith S, Menon RS, Matthews PM. Imaging attentional modulation of pain in the periaqueductal gray in humans. J Neurosci. 2002 Apr 1;22(7):2748-52. doi: 10.1523/JNEUROSCI.22-07-02748.2002.

  PMID: 11923440 BACKGROUND

• Seifert F, Bschorer K, De Col R, Filitz J, Peltz E, Koppert W, Maihofner C. Medial prefrontal cortex activity is predictive for hyperalgesia and pharmacological antihyperalgesia. J Neurosci. 2009 May 13;29(19):6167-75. doi: 10.1523/JNEUROSCI.4654-08.2009.

  PMID: 19439594 BACKGROUND

MeSH Terms

Conditions

Pain

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• James W Ibinson, MD, PhD

  University of Pittsburgh

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Instructor

Study Record Dates

• First Submitted: November 15, 2010
• First Posted: November 17, 2010
• Study Start: November 1, 2010
• Primary Completion: June 1, 2011
• Study Completion: October 1, 2016
• Last Updated: June 26, 2017

Record last verified: 2017-06

Locations

US (1)