NCT01233531

Brief Summary

Cash transfers to young women for staying in school and its effect on acquiring HIV

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
2,537

participants targeted

Target at P75+ for phase_3 hiv

Timeline
Completed

Started Mar 2011

Typical duration for phase_3 hiv

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

November 1, 2010

Completed
2 days until next milestone

First Posted

Study publicly available on registry

November 3, 2010

Completed
4 months until next milestone

Study Start

First participant enrolled

March 1, 2011

Completed
4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2015

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2015

Completed
Last Updated

March 25, 2025

Status Verified

March 1, 2025

Enrollment Period

4 years

First QC Date

November 1, 2010

Last Update Submit

March 20, 2025

Conditions

HIV

Outcome Measures

Primary Outcomes (1)

  • HIV Incidence

    To determine whether young women who are randomized to receive CCTs conditional on school attendance have a lower incidence of HIV infection over time compared to young women who are not randomized to receive cash transfers.

    4 years

Secondary Outcomes (2)

  • HSV-2 incidence

    4 years

  • HSV Incidence

    4 years

Study Arms (2)

A--Monthly cash transfers

OTHER

Monthly cash transfer payments

Behavioral: monthly cash transfer payments for attending school

B--No cash transfers

OTHER

No cash transfers.

Behavioral: monthly cash transfer payments for attending schoolBehavioral: B--No cash transfers

Interventions

monthly cash transfer payments for attending schoolBEHAVIORAL

In the intervention, young women and their households will be randomized in 1:1 ratio to receive monthly cash transfer payments, conditional on the young woman attending school, or to the control arm. Young women will be recruited at the beginning of grades 8 through 11 in the first year of the study.

A--Monthly cash transfersB--No cash transfers
B--No cash transfersBEHAVIORAL

No monthly cash transfers

B--No cash transfers

Eligibility Criteria

Age13 Years - 20 Years
Sexfemale
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Female aged 13 to 20 years.
  • Enrolled in grades 8, 9, 10 or 11 at the beginning of the study at schools in the AHDSS study site
  • Intending to continue to live in the study site until the end of the follow-up period.
  • Be willing and able to consent/assent to all study procedures including HIV and HSV-2 testing.
  • Able to read sufficiently to use ACASI.
  • Have a bank or post office account or have documentation to be able to open a bank or post office account (i.e., birth certificate, South African National Identification Book, or passport and proof of residence). Post Office accounts will only be required for participants in the Intervention arm.
  • Parent/Legal Guardian who lives with young woman, willing and able to consent to all study procedures including HIV and HSV-2 testing.
  • Parent/Legal Guardian has a bank or post office account or has documentation to be able to open a bank or post office account (i.e. South African National Identification Book, or passport and proof of residence). Note that the account may be opened in the name of any adult who resides in the household with the young woman.

You may not qualify if:

  • Pregnant by self-report at baseline.
  • Married at baseline.
  • No parent or legal guardian living in household.
  • Any other reason that the staff feels would jeopardize the health or well-being of the participant or staff or would prevent proper conduct of the study.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Agincourt

Acornhoek, South Africa

Location

Related Publications (5)

  • Rosenberg M, Beidelman E, Chen X, Canning D, Kobayashi L, Kahn K, Pettifor A, Kabudula CW. The impact of a randomized cash transfer intervention on mortality of adult household members in rural South Africa, 2011-2022. Soc Sci Med. 2023 May;324:115883. doi: 10.1016/j.socscimed.2023.115883. Epub 2023 Mar 31.

    PMID: 37023659DERIVED

  • Jayaweera RT, Goin D, Twine R, Neilands TB, Wagner RG, Lippman SA, Kahn K, Pettifor A, Ahern J. Associations between WASH-related violence and depressive symptoms in adolescent girls and young women in South Africa (HPTN 068): a cross-sectional analysis. BMJ Open. 2022 Jul 5;12(7):e061032. doi: 10.1136/bmjopen-2022-061032.

    PMID: 35790334DERIVED

  • DeLong SM, Powers KA, Pence BW, Maman S, Dunkle KL, Selin A, Twine R, Wagner RG, Gomez-Olive FX, MacPhail C, Kahn K, Pettifor A. Longitudinal Trajectories of Physical Intimate Partner Violence Among Adolescent Girls in Rural South Africa: Findings From HPTN 068. J Adolesc Health. 2020 Jul;67(1):69-75. doi: 10.1016/j.jadohealth.2019.12.016. Epub 2020 Feb 13.

    PMID: 32061464DERIVED

  • MacPhail C, Khoza N, Selin A, Julien A, Twine R, Wagner RG, Gomez-Olive X, Kahn K, Wang J, Pettifor A. Cash transfers for HIV prevention: what do young women spend it on? Mixed methods findings from HPTN 068. BMC Public Health. 2017 Jul 11;18(1):10. doi: 10.1186/s12889-017-4513-3.

    PMID: 28697762DERIVED

  • Pettifor A, MacPhail C, Hughes JP, Selin A, Wang J, Gomez-Olive FX, Eshleman SH, Wagner RG, Mabuza W, Khoza N, Suchindran C, Mokoena I, Twine R, Andrew P, Townley E, Laeyendecker O, Agyei Y, Tollman S, Kahn K. The effect of a conditional cash transfer on HIV incidence in young women in rural South Africa (HPTN 068): a phase 3, randomised controlled trial. Lancet Glob Health. 2016 Dec;4(12):e978-e988. doi: 10.1016/S2214-109X(16)30253-4. Epub 2016 Nov 1.

    PMID: 27815148DERIVED

Study Officials

  • Audrey Pettifor

    University of North Carolina

    STUDY CHAIR

  • Xavier Gomez-Olive

    Wits Rural Public Health and Health Transitions Research Unit

    PRINCIPAL INVESTIGATOR

  • Kathleen Kahn

    University of Witwatersrand, South Africa

    PRINCIPAL INVESTIGATOR

  • Catherine McPhail

    Reproductive Health & HIV Research Unit, University of Witwatersrand

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
NETWORK
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 1, 2010

First Posted

November 3, 2010

Study Start

March 1, 2011

Primary Completion

March 1, 2015

Study Completion

March 1, 2015

Last Updated

March 25, 2025

Record last verified: 2025-03

Locations

ZA(1)