Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin
PEGASUS
A Randomized, Double-Blind, Placebo Controlled, Parallel Group, Multinational Trial, to Assess the Prevention of Thrombotic Events With Ticagrelor Compared to Placebo on a Background of Acetyl Salicylic Acid (ASA) Therapy in Patients With History of Myocardial Infarction
2 other identifiers
interventional
21,379
31 countries
827
Brief Summary
This study is being carried out to see if a new drug called ticagrelor given twice daily in addition to the ASA therapy decreases the frequency of cardiovascular events (e.g., death from heart disease, heart attack, or stroke).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Oct 2010
Typical duration for phase_3
827 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 9, 2010
CompletedStudy Start
First participant enrolled
October 1, 2010
CompletedFirst Posted
Study publicly available on registry
October 21, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2014
CompletedResults Posted
Study results publicly available
December 9, 2015
CompletedJanuary 25, 2016
December 1, 2015
4.2 years
July 9, 2010
November 4, 2015
December 18, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Kaplan-Meier Estimate of the Percentage of Patients Who Experienced Cardiovascular Death (CV Death), Myocardial Infarction (MI) or Stroke Within 3 Years From Randomization
Participants with CV death, MI or Stroke. If no event, censoring occurs at the earliest of the efficacy cut-off date 14 Sep 2014, withdrawal of consent, non-CV death or at the last time point of complete clinical event assessment. Events were adjudicated by a blinded endpoint committee. The Kaplan-Meier estimate reports the percentage of patients who experienced CV Death, MI or stroke within 3 years from randomization
Randomization up to 47 months
Kaplan-Meier Estimate of the Percentage of Patients Who Experienced a TIMI Major Bleeding Within 3 Years From First Dose of Study Drug Units: Percentage of Patients
A Thrombolysis in Myocardial Infarction (TIMI) study group major bleeding is defined as any fatal bleeding (leading directly to death within 7 days), any intrcranial bleeding or any clinically overt signs of haemorrhage associated with a drop in Haemoglobin of \>= 5g/dL. Events were adjudicated by a clinical events committee. Censoring ocurrs at 7 days following last dose of study drug. The Kaplan-Meier estimate reports the percentage of patients who experienced a TIMI Major bleeding within 3 years from first dose of study drug
First dosing up to 48 months
Secondary Outcomes (2)
Kaplan-Meier Estimate of the Percentage of Patients Who Experienced Cardiovascular Death (CV Death) Within 3 Years From Randomization
Randomization up to 47 months
Kaplan-Meier Estimate of the Percentage of Patients Who Died From Any Cause Within 3 Years From Randomization
Randomization up to 47 months
Study Arms (3)
1
EXPERIMENTALOral Treatment
2
EXPERIMENTALOral Treatment
3
PLACEBO COMPARATOROral Treatment
Interventions
Eligibility Criteria
You may qualify if:
- Person who had a heart attack within 1 - 3 years ago and at least one additional risk factor: Age ≥ 65 years old, Diabetes requiring medication, Documented history of 2nd prior MI (\>1 year ago). Angiographic evidence of multivessel CAD, and / or Chronic, non-end stage renal dysfunction.
- Females of child-bearing potential must have a negative pregnancy test at enrollment
- Persons who are currently taking aspirin between 75 and 150 mg once daily
You may not qualify if:
- Persons who are being treated with agents inhibiting blood clotting if the agent cannot be stopped at study start
- Persons who have planned coronary, cerebrovascular, or peripheral arterial Revascularization (invasive surgery) at study start
- Persons with known bleeding disorders
- Persons who need chronic oral anticoagulant therapy or chronic low-molecular-weight heparin
- Persons with a history of ischemic stroke
- Persons with a history of intracranial bleeding at any time, a tumor or blood vessel abnormality in the brain and/or spinal cord at any time, a history of surgery involving the brain or spinal cord within the last 5 years, or a history of bleeding from the gastrointestinal tract (eg, esophagus, stomach, colon, rectum) within the last 6 months or a major surgery within the last 30 days.
- Persons considered to be at risk of bradycardic events unless already treated with a permanent pacemaker
- Persons who have had open heart surgery within the past 5 years, unless the person had a heart attack after the surgery
- Persons with known severe liver disease
- Persons with kidney failure requiring dialysis
- Persons with life expectancy \< 1 year
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- AstraZenecalead
Study Sites (827)
Research Site
Alexander City, Alabama, United States
Research Site
Athens, Alabama, United States
Research Site
Birmingham, Alabama, United States
Research Site
Huntsville, Alabama, United States
Research Site
Mobile, Alabama, United States
Research Site
Sheffield, Alabama, United States
Research Site
Glendale, Arizona, United States
Research Site
Phoenix, Arizona, United States
Research Site
Jonesboro, Arkansas, United States
Research Site
Little Rock, Arkansas, United States
Research Site
Alhambra, California, United States
Research Site
Anaheim, California, United States
Research Site
Bakersfield, California, United States
Research Site
Fountain Valley, California, United States
Research Site
La Mesa, California, United States
Research Site
Larkspur, California, United States
Research Site
Lomita, California, United States
Research Site
Los Angeles, California, United States
Research Site
Modesto, California, United States
Research Site
Newport Beach, California, United States
Research Site
Oakland, California, United States
Research Site
Oceanside, California, United States
Research Site
San Diego, California, United States
Research Site
San Marino, California, United States
Research Site
Santa Rosa, California, United States
Research Site
Ventura, California, United States
Research Site
Westlake Village, California, United States
Research Site
Aurora, Colorado, United States
Research Site
Colorado Springs, Colorado, United States
Research Site
Littleton, Colorado, United States
Research Site
Loveland, Colorado, United States
Research Site
Hartford, Connecticut, United States
Research Site
Stamford, Connecticut, United States
Research Site
Newark, Delaware, United States
Research Site
Washington D.C., District of Columbia, United States
Research Site
Boca Raton, Florida, United States
Research Site
Clearwater, Florida, United States
Research Site
Coral Springs, Florida, United States
Research Site
Crystal River, Florida, United States
Research Site
Davie, Florida, United States
Research Site
Daytona Beach, Florida, United States
Research Site
Fort Lauderdale, Florida, United States
Research Site
Gainesville, Florida, United States
Research Site
Hialeah, Florida, United States
Research Site
Hollywood, Florida, United States
Research Site
Jacksonville, Florida, United States
Research Site
Jupiter, Florida, United States
Research Site
Largo, Florida, United States
Research Site
Leesburg, Florida, United States
Research Site
Miami, Florida, United States
Research Site
Miami Beach, Florida, United States
Research Site
Naples, Florida, United States
Research Site
Ocala, Florida, United States
Research Site
Orlando, Florida, United States
Research Site
Pannama City, Florida, United States
Research Site
Pensacola, Florida, United States
Research Site
Port Charlotte, Florida, United States
Research Site
Safety Harbor, Florida, United States
Research Site
Sarasota, Florida, United States
Research Site
South Miami, Florida, United States
Research Site
St. Petersburg, Florida, United States
Research Site
Tallahassee, Florida, United States
Research Site
The Villages, Florida, United States
Research Site
Wellington, Florida, United States
Research Site
West Palm Beach, Florida, United States
Research Site
Atlanta, Georgia, United States
Research Site
Augusta, Georgia, United States
Research Site
Cumming, Georgia, United States
Research Site
Honolulu, Hawaii, United States
Research Site
Boise, Idaho, United States
Research Site
Aurora, Illinois, United States
Research Site
Bannockburn, Illinois, United States
Research Site
Chicago, Illinois, United States
Research Site
Melrose Park, Illinois, United States
Research Site
Normal, Illinois, United States
Research Site
Rock Island, Illinois, United States
Research Site
Avon, Indiana, United States
Research Site
Elkhart, Indiana, United States
Research Site
Fort Wayne, Indiana, United States
Research Site
Franklin, Indiana, United States
Research Site
Indianapolis, Indiana, United States
Research Site
Muncie, Indiana, United States
Research Site
Munster, Indiana, United States
Research Site
Iowa City, Iowa, United States
Research Site
Hutchinson, Kansas, United States
Research Site
Crestview Hills, Kentucky, United States
Research Site
Lexington, Kentucky, United States
Research Site
Louisville, Kentucky, United States
Research Site
Alexandria, Louisiana, United States
Research Site
Covington, Louisiana, United States
Research Site
Minden, Louisiana, United States
Research Site
New Iberia, Louisiana, United States
Research Site
Opelousas, Louisiana, United States
Research Site
Shreveport, Louisiana, United States
Research Site
Slidell, Louisiana, United States
Research Site
Auburn, Maine, United States
Research Site
Bangor, Maine, United States
Research Site
Biddeford, Maine, United States
Research Site
South Portland, Maine, United States
Research Site
Baltimore, Maryland, United States
Research Site
Columbia, Maryland, United States
Research Site
Oxon Hill, Maryland, United States
Research Site
Salisbury, Maryland, United States
Research Site
Ayer, Massachusetts, United States
Research Site
Boston, Massachusetts, United States
Research Site
Burlington, Massachusetts, United States
Research Site
Haverhill, Massachusetts, United States
Research Site
North Dartmouth, Massachusetts, United States
Research Site
Alpena, Michigan, United States
Research Site
Ann Arbor, Michigan, United States
Research Site
Detroit, Michigan, United States
Research Site
Flint, Michigan, United States
Research Site
Grand Blanc, Michigan, United States
Research Site
Grand Rapids, Michigan, United States
Research Site
Jackson, Michigan, United States
Research Site
Lapeer, Michigan, United States
Research Site
Marquette, Michigan, United States
Research Site
Petoskey, Michigan, United States
Research Site
Pontiac, Michigan, United States
Research Site
Saginaw, Michigan, United States
Research Site
Southfield, Michigan, United States
Research Site
Ypsilanti, Michigan, United States
Research Site
Baxter, Minnesota, United States
Research Site
Duluth, Minnesota, United States
Research Site
Minneapolis, Minnesota, United States
Research Site
Robbinsdale, Minnesota, United States
Research Site
Saint Cloud, Minnesota, United States
Research Site
Biloxi, Mississippi, United States
Research Site
Tupelo, Mississippi, United States
Research Site
Columbia, Missouri, United States
Research Site
Kansas City, Missouri, United States
Research Site
St Louis, Missouri, United States
Research Site
Billings, Montana, United States
Research Site
Great Falls, Montana, United States
Research Site
Kalispell, Montana, United States
Research Site
Lincoln, Nebraska, United States
Research Site
Omaha, Nebraska, United States
Research Site
Papillion, Nebraska, United States
Research Site
Reno, Nevada, United States
Research Site
Bridgewater, New Jersey, United States
Research Site
Elizabeth, New Jersey, United States
Research Site
Elmer, New Jersey, United States
Research Site
Haddon Heights, New Jersey, United States
Research Site
Linden, New Jersey, United States
Research Site
Mine Hill, New Jersey, United States
Research Site
Newark, New Jersey, United States
Research Site
Ridgewood, New Jersey, United States
Research Site
Somerset, New Jersey, United States
Research Site
Albuquerque, New Mexico, United States
Research Site
Buffalo, New York, United States
Research Site
Cortlandt Manor, New York, United States
Research Site
Mineola, New York, United States
Research Site
New Windsor, New York, United States
Research Site
Poughkeepsie, New York, United States
Research Site
Saratoga Springs, New York, United States
Research Site
Southampton, New York, United States
Research Site
Stony Brook, New York, United States
Research Site
The Bronx, New York, United States
Research Site
Williamsville, New York, United States
Research Site
Asheville, North Carolina, United States
Research Site
Burlington, North Carolina, United States
Research Site
Cary, North Carolina, United States
Research Site
Greensboro, North Carolina, United States
Research Site
Hickory, North Carolina, United States
Research Site
Morganton, North Carolina, United States
Research Site
Pinehurst, North Carolina, United States
Research Site
Raleigh, North Carolina, United States
Research Site
Rocky Mount, North Carolina, United States
Research Site
Sanford, North Carolina, United States
Research Site
Smithfield, North Carolina, United States
Research Site
Statesville, North Carolina, United States
Research Site
Wilmington, North Carolina, United States
Research Site
Grand Forks, North Dakota, United States
Research Site
Akron, Ohio, United States
Research Site
Canton, Ohio, United States
Research Site
Cincinnati, Ohio, United States
Research Site
Cleveland, Ohio, United States
Research Site
Columbus, Ohio, United States
Research Site
Dayton, Ohio, United States
Research Site
Fairfield, Ohio, United States
Research Site
Mansfield, Ohio, United States
Research Site
Sandusky, Ohio, United States
Research Site
Springfield, Ohio, United States
Research Site
Toledo, Ohio, United States
Research Site
Youngstown, Ohio, United States
Research Site
Zanesville, Ohio, United States
Research Site
Oklahoma City, Oklahoma, United States
Research Site
Tulsa, Oklahoma, United States
Research Site
Bend, Oregon, United States
Research Site
Portland, Oregon, United States
Research Site
Altoona, Pennsylvania, United States
Research Site
Beaver, Pennsylvania, United States
Research Site
Bethlehem, Pennsylvania, United States
Research Site
Chambersburg, Pennsylvania, United States
Research Site
Doylestown, Pennsylvania, United States
Research Site
Erie, Pennsylvania, United States
Research Site
Johnstown, Pennsylvania, United States
Research Site
Lancaster, Pennsylvania, United States
Research Site
Langhorne, Pennsylvania, United States
Research Site
Philadelphia, Pennsylvania, United States
Research Site
Pittsburgh, Pennsylvania, United States
Research Site
Scranton, Pennsylvania, United States
Research Site
Sellersville, Pennsylvania, United States
Research Site
West Chester, Pennsylvania, United States
Research Site
York, Pennsylvania, United States
Research Site
Providence, Rhode Island, United States
Research Site
Anderson, South Carolina, United States
Research Site
Charleston, South Carolina, United States
Research Site
Florence, South Carolina, United States
Research Site
Greenville, South Carolina, United States
Research Site
Rapid City, South Dakota, United States
Research Site
Watertown, South Dakota, United States
Research Site
Germantown, Tennessee, United States
Research Site
Jackson, Tennessee, United States
Research Site
Knoxville, Tennessee, United States
Research Site
Nashville, Tennessee, United States
Research Site
Oak Ridge, Tennessee, United States
Research Site
Tullahoma, Tennessee, United States
Research Site
Austin, Texas, United States
Research Site
Dallas, Texas, United States
Research Site
Fort Worth, Texas, United States
Research Site
Georgetown, Texas, United States
Research Site
Grapevine, Texas, United States
Research Site
Houston, Texas, United States
Research Site
Katy, Texas, United States
Research Site
Kingwood, Texas, United States
Research Site
McAllen, Texas, United States
Research Site
Plano, Texas, United States
Research Site
Round Rock, Texas, United States
Research Site
San Antonio, Texas, United States
Research Site
Tomball, Texas, United States
Research Site
Tyler, Texas, United States
Research Site
Victoria, Texas, United States
Research Site
Provo, Utah, United States
Research Site
Burlington, Vermont, United States
Research Site
Alexandria, Virginia, United States
Research Site
Charlottesville, Virginia, United States
Research Site
Danville, Virginia, United States
Research Site
Falls Church, Virginia, United States
Research Site
Lynchburg, Virginia, United States
Research Site
Manassas, Virginia, United States
Research Site
Norfolk, Virginia, United States
Research Site
Richmond, Virginia, United States
Research Site
Winchester, Virginia, United States
Research Site
Bellevue, Washington, United States
Research Site
Everett, Washington, United States
Research Site
Spokane, Washington, United States
Research Site
Tacoma, Washington, United States
Research Site
Green Bay, Wisconsin, United States
Research Site
Wausau, Wisconsin, United States
Research Site
Bahía Blanca, Argentina
Research Site
Buenos Aires, Argentina
Research Site
Ciudad Autonoma de BA, Argentina
Research Site
Ciudad de Buenos Aires, Argentina
Research Site
Ciudadela, Argentina
Research Site
Coronel Suárez, Argentina
Research Site
Corrientes, Argentina
Research Site
Córdoba, Argentina
Research Site
Haedo, Argentina
Research Site
La Plata, Argentina
Research Site
Mar del Plata, Argentina
Research Site
Ramos Mejía, Argentina
Research Site
Rosario, Argentina
Research Site
Rosario Santa Fe, Argentina
Research Site
San Luis, Argentina
Research Site
San Miguel de Tucumán, Argentina
Research Site
San Nicolás, Argentina
Research Site
San Salvador de Jujuy, Argentina
Research Site
Santa Fe, Argentina
Research Site
Santa Fé, Argentina
Research Site
Zárate, Argentina
Research Site
Adelaide, Australia
Research Site
Ashford, Australia
Research Site
Auchenflower, Australia
Research Site
Ballarat, Australia
Research Site
Bruce, Australia
Research Site
Chermside, Australia
Research Site
Clayton, Australia
Research Site
Concord, Australia
Research Site
East Saint Kilda, Australia
Research Site
Elizabeth Vale, Australia
Research Site
Epping, Australia
Research Site
Fremantle, Australia
Research Site
Geelong, Australia
Research Site
Gosford, Australia
Research Site
Greenslopes, Australia
Research Site
Herston, Australia
Research Site
Joondalup, Australia
Research Site
Kingswood, Australia
Research Site
Kogorah, Australia
Research Site
Launceston, Australia
Research Site
Melbourne, Australia
Research Site
Nedlands, Australia
Research Site
New Lambton Heights, Australia
Research Site
Richmond, Australia
Research Site
St Leonards, Australia
Research Site
Wollongong, Australia
Research Site
Woodville, Australia
Research Site
Woolloongabba, Australia
Research Site
Aalst, Belgium
Research Site
Antwerp, Belgium
Research Site
Bonheiden, Belgium
Research Site
Bouge, Belgium
Research Site
Brasschaat, Belgium
Research Site
Brussels, Belgium
Research Site
Brussels (Anderlecht), Belgium
Research Site
Brussels (Jette), Belgium
Research Site
Brussels (Woluwé-St-Lambert), Belgium
Research Site
Charleroi, Belgium
Research Site
Edegem, Belgium
Research Site
Genk, Belgium
Research Site
Ghent, Belgium
Research Site
Hasselt, Belgium
Research Site
Huy, Belgium
Research Site
La Louvière, Belgium
Research Site
Leuven, Belgium
Research Site
Liège, Belgium
Research Site
Mechelen, Belgium
Research Site
Mol, Belgium
Research Site
Ottignies, Belgium
Research Site
Roeselare, Belgium
Research Site
Tienen, Belgium
Research Site
Turnhout, Belgium
Research Site
Yvoir, Belgium
Research Site
Zottegem, Belgium
Research Site
Aracaju, Brazil
Research Site
Belo Horizonte, Brazil
Research Site
Blumenau, Brazil
Research Site
Brasília, Brazil
Research Site
Campina Grande do Sul, Brazil
Research Site
Campinas, Brazil
Research Site
Campo Grande, Brazil
Research Site
Curitiba, Brazil
Research Site
Goiânia, Brazil
Research Site
Maceió, Brazil
Research Site
Marília, Brazil
Research Site
Porto Alegre, Brazil
Research Site
Ribeirão Preto, Brazil
Research Site
Rio de Janeiro, Brazil
Research Site
S.J.Rio Preto, Brazil
Research Site
Salvador, Brazil
Research Site
São José do Rio Preto, Brazil
Research Site
São Paulo, Brazil
Research Site
Uberlândia, Brazil
Research Site
Votuporanga, Brazil
Research Site
Dimitrovgrad, Bulgaria
Research Site
Gotse Delchev, Bulgaria
Research Site
Pernik, Bulgaria
Research Site
Pleven, Bulgaria
Research Site
Plovdiv, Bulgaria
Research Site
Razlog, Bulgaria
Research Site
Rousse, Bulgaria
Research Site
Sevlievo, Bulgaria
Research Site
Sofia, Bulgaria
Research Site
Varna, Bulgaria
Research Site
Veliko Tarnovo, Bulgaria
Research Site
Edmonton, Alberta, Canada
Research Site
Kelowna, British Columbia, Canada
Research Site
New Westminster, British Columbia, Canada
Research Site
Penticton, British Columbia, Canada
Research Site
Surrey, British Columbia, Canada
Research Site
Vancouver, British Columbia, Canada
Research Site
Victoria, British Columbia, Canada
Research Site
Moncton, New Brunswick, Canada
Research Site
Saint John, New Brunswick, Canada
Research Site
St. John's, Newfoundland and Labrador, Canada
Research Site
Halifax, Nova Scotia, Canada
Research Site
Brampton, Ontario, Canada
Research Site
Burlington, Ontario, Canada
Research Site
Cambridge, Ontario, Canada
Research Site
Cornwall, Ontario, Canada
Research Site
Greater Sudbury, Ontario, Canada
Research Site
Hamilton, Ontario, Canada
Research Site
Kitchener, Ontario, Canada
Research Site
London, Ontario, Canada
Research Site
Mississauga, Ontario, Canada
Research Site
Newmarket, Ontario, Canada
Research Site
North York, Ontario, Canada
Research Site
Oshawa, Ontario, Canada
Research Site
Ottawa, Ontario, Canada
Research Site
Sarnia, Ontario, Canada
Research Site
Scarborough Village, Ontario, Canada
Research Site
Thunder Bay, Ontario, Canada
Research Site
Toronto, Ontario, Canada
Research Site
Windsor, Ontario, Canada
Research Site
Chicoutimi, Quebec, Canada
Research Site
Gatineau, Quebec, Canada
Research Site
Greenfield Park, Quebec, Canada
Research Site
Laval, Quebec, Canada
Research Site
Lévis, Quebec, Canada
Research Site
Longueuil, Quebec, Canada
Research Site
Montreal, Quebec, Canada
Research Site
Québec, Quebec, Canada
Research Site
Saint-Charles-Borromée, Quebec, Canada
Research Site
Saint-Georges, Quebec, Canada
Research Site
Saint-Jérôme, Quebec, Canada
Research Site
Saint-Lambert, Quebec, Canada
Research Site
Terrebonne, Quebec, Canada
Research Site
Thetford-Mines, Quebec, Canada
Research Site
Val-d'Or, Quebec, Canada
Research Site
Saskatoon, Saskatchewan, Canada
Research Site
Concepción, Chile
Research Site
Osorno, Chile
Research Site
Rancagua, Chile
Research Site
Santiago, Chile
Research Site
Santiago Centro, Chile
Research Site
Temuco, Chile
Research Site
Viña del Mar, Chile
Research Site
Beijing, China
Research Site
Changsha, China
Research Site
Chongqing, China
Research Site
Guangzhou, China
Research Site
Hangzhou, China
Research Site
Lanzhou, China
Research Site
Nanjing, China
Research Site
Shanghai, China
Research Site
Shengyang, China
Research Site
Shenyang, China
Research Site
Taiyuan, China
Research Site
Wuhan, China
Research Site
Xi'an, China
Research Site
Armenia, Colombia
Research Site
Barranquilla, Colombia
Research Site
Bogotá, Colombia
Research Site
Bogotá D.C., Colombia
Research Site
Bucaramanga, Colombia
Research Site
Cali, Colombia
Research Site
Cartagena, Colombia
Research Site
Manizales, Colombia
Research Site
Medellín, Colombia
Research Site
Medillin, Colombia
Research Site
Brno, Czechia
Research Site
Chomutov, Czechia
Research Site
Čáslav, Czechia
Research Site
Česká Lípa, Czechia
Research Site
Český Krumlov, Czechia
Research Site
Havířov, Czechia
Research Site
Kroměříž, Czechia
Research Site
Kyjov, Czechia
Research Site
Liberec, Czechia
Research Site
Mariánské Lázně, Czechia
Research Site
Ostrava, Czechia
Research Site
Ostrava-Poruba, Czechia
Research Site
Pelhřimov, Czechia
Research Site
Prague, Czechia
Research Site
Příbram, Czechia
Research Site
Slaný, Czechia
Research Site
Teplice, Czechia
Research Site
Ústí nad Labem, Czechia
Research Site
Ústí nad Orlicí, Czechia
Research Site
Zábřeh nad Odrou, Czechia
Research Site
Znojmo, Czechia
Research Site
Abbeville, France
Research Site
Albi, France
Research Site
Angers, France
Research Site
Avignon, France
Research Site
Bayonne, France
Research Site
Cannes, France
Research Site
Créteil, France
Research Site
Dijon, France
Research Site
Jossigny, France
Research Site
La Rochelle, France
Research Site
Le Chesnay, France
Research Site
Le Coudray, France
Research Site
Limoges, France
Research Site
Marseille, France
Research Site
Metz, France
Research Site
Nice, France
Research Site
Nîmes, France
Research Site
Orléans, France
Research Site
Paris, France
Research Site
Pessac, France
Research Site
Poitiers, France
Research Site
Toulouse, France
Research Site
Tourcoing, France
Research Site
Bad Krozingen, Germany
Research Site
Bad Mergentheim, Germany
Research Site
Bad Nauheim, Germany
Research Site
Berlin, Germany
Research Site
Bielefeld, Germany
Research Site
Coburg, Germany
Research Site
Deggingen, Germany
Research Site
Dortmund, Germany
Research Site
Dresden, Germany
Research Site
Essen, Germany
Research Site
Esslingen am Neckar, Germany
Research Site
Frankfurt, Germany
Research Site
Hamburg, Germany
Research Site
Heidelberg, Germany
Research Site
Kassel, Germany
Research Site
Kiel, Germany
Research Site
Leipzig, Germany
Research Site
Limburg, Germany
Research Site
Ludwigshafen, Germany
Research Site
Lübeck, Germany
Research Site
Mainz, Germany
Research Site
Mönchengladbach, Germany
Research Site
Ulm, Germany
Research Site
Warendorf, Germany
Research Site
Witten, Germany
Research Site
Ballasagyarmat, Hungary
Research Site
Békéscsaba, Hungary
Research Site
Budapest, Hungary
Research Site
Cegléd, Hungary
Research Site
Debrecen, Hungary
Research Site
Eger, Hungary
Research Site
Gyula, Hungary
Research Site
Kalocsa, Hungary
Research Site
Kecskemét, Hungary
Research Site
Mosonmagyaróvár, Hungary
Research Site
Nyíregyháza, Hungary
Research Site
Pécs, Hungary
Research Site
Sopron, Hungary
Research Site
Szeged, Hungary
Research Site
Szekszárd, Hungary
Research Site
Székesfehérvár, Hungary
Research Site
Szolnok, Hungary
Research Site
Zalaegerszeg, Hungary
Research Site
Albano Laziale, Italy
Research Site
Bari, Italy
Research Site
Benevento, Italy
Research Site
Brescia, Italy
Research Site
Carpi, Italy
Research Site
Catania, Italy
Research Site
Genova, Italy
Research Site
Legnano, Italy
Research Site
Lucca, Italy
Research Site
Massa, Italy
Research Site
Milan, Italy
Research Site
Napoli, Italy
Research Site
Osio Sotto Frazione Di Zingoni, Italy
Research Site
Parma, Italy
Research Site
Pavia, Italy
Research Site
Perugia, Italy
Research Site
Pescara, Italy
Research Site
Pisa, Italy
Research Site
Reggio Emilia, Italy
Research Site
Roma, Italy
Research Site
Rozzano, Italy
Research Site
S Maria Capua Vetere, Italy
Research Site
Sanremo, Italy
Research Site
Sassari, Italy
Research Site
Sessa Aurunca, Italy
Research Site
Siena, Italy
Research Site
Sorrento NA, Italy
Research Site
Vimercate, Italy
Research Site
Akishima-shi, Japan
Research Site
Amagasaki-shi, Japan
Research Site
Beppu-shi, Japan
Research Site
Chūōku, Japan
Research Site
Daito-shi, Japan
Research Site
Fukui-shi, Japan
Research Site
Funabashi-shi, Japan
Research Site
Gifu, Japan
Research Site
Hamamatsu, Japan
Research Site
Himeji-shi, Japan
Research Site
Imabari, Japan
Research Site
Isehara-shi, Japan
Research Site
Kamogawa-shi, Japan
Research Site
Kanazawa, Japan
Research Site
Kawachinagano-shi, Japan
Research Site
Kisarazu-shi, Japan
Research Site
Komatsushima-shi, Japan
Research Site
Koriyama-shi, Japan
Research Site
Kumamoto, Japan
Research Site
Kure-shi, Japan
Research Site
Kusatsu-shi, Japan
Research Site
Kyoto, Japan
Research Site
Maebashi, Japan
Research Site
Matsue, Japan
Research Site
Matsumoto-shi, Japan
Research Site
Matsuyama, Japan
Research Site
Meguro-ku, Japan
Research Site
Miyazaki, Japan
Research Site
Osaka, Japan
Research Site
Saga, Japan
Research Site
Sagamihara-shi, Japan
Research Site
Saitama-shi, Japan
Research Site
Sakaide-shi, Japan
Research Site
Sakaishi, Japan
Research Site
Sapporo, Japan
Research Site
Sayama-shi, Japan
Research Site
Shimada-shi, Japan
Research Site
Shinagawa-ku, Japan
Research Site
Shizuoka, Japan
Research Site
Suwa-shi, Japan
Research Site
Takarazuka-shi, Japan
Research Site
Takasaki-shi, Japan
Research Site
Takatsuki-shi, Japan
Research Site
Tomakomai-shi, Japan
Research Site
Toyonaka-shi, Japan
Research Site
Ueda-shi, Japan
Research Site
Wakayama, Japan
Research Site
Wako-shi, Japan
Research Site
Yatsushiro-shi, Japan
Research Site
Yokohama, Japan
Research Site
Almere Stad, Netherlands
Research Site
Amersfoort, Netherlands
Research Site
Amsterdam, Netherlands
Research Site
Arnhem, Netherlands
Research Site
Beverwijk, Netherlands
Research Site
Breda, Netherlands
Research Site
Delft, Netherlands
Research Site
Den Helder, Netherlands
Research Site
Deventer, Netherlands
Research Site
Drachten, Netherlands
Research Site
Ede, Netherlands
Research Site
Eindhoven, Netherlands
Research Site
Goes, Netherlands
Research Site
Groningen, Netherlands
Research Site
Hardenberg, Netherlands
Research Site
Heerenveen, Netherlands
Research Site
Heerlen, Netherlands
Research Site
Helmond, Netherlands
Research Site
Hilversum, Netherlands
Research Site
Hoofddorp, Netherlands
Research Site
Hoogeveen, Netherlands
Research Site
Leiderdorp, Netherlands
Research Site
Maastricht, Netherlands
Research Site
Nieuwegein, Netherlands
Research Site
Nijmegen, Netherlands
Research Site
Oss, Netherlands
Research Site
Roosendaal, Netherlands
Research Site
Rotterdam, Netherlands
Research Site
Schiedam, Netherlands
Research Site
Shertogenbosch, Netherlands
Research Site
Sittardgeleen, Netherlands
Research Site
Sneek, Netherlands
Research Site
The Hague, Netherlands
Research Site
Tiel, Netherlands
Research Site
Tilburg, Netherlands
Research Site
Veldhoven, Netherlands
Research Site
Bergen, Norway
Research Site
Bodø, Norway
Research Site
Flekkefjord, Norway
Research Site
Hamar, Norway
Research Site
Levanger, Norway
Research Site
Lillehammer, Norway
Research Site
Nesttun, Norway
Research Site
Oslo, Norway
Research Site
Skien, Norway
Research Site
Tromsø, Norway
Research Site
Tynset, Norway
Research Site
Arequipa, Peru
Research Site
Callao, Peru
Research Site
Lima, Peru
Research Site
San Borja, Peru
Research Site
Trujillo, Peru
Research Site
Cebu City, Philippines
Research Site
Fuente Osmena Cebu City, Philippines
Research Site
Iloilo City, Philippines
Research Site
Las Piñas, Philippines
Research Site
Lipa City, Philippines
Research Site
Mandaluyong, Philippines
Research Site
Manila, Philippines
Research Site
Pasig, Philippines
Research Site
Quezon, Philippines
Research Site
Quezon City, Philippines
Research Site
San Juan City, Philippines
Research Site
Bialystok, Poland
Research Site
Bielsko-Biala, Poland
Research Site
Bydgoszcz, Poland
Research Site
Chorzów, Poland
Research Site
Gdansk, Poland
Research Site
Gdynia, Poland
Research Site
Giżycko, Poland
Research Site
Krakow, Poland
Research Site
Legnica, Poland
Research Site
Lodz, Poland
Research Site
Lubin, Poland
Research Site
Nowa Sól, Poland
Research Site
Olsztyn, Poland
Research Site
Opole, Poland
Research Site
Ostrów Mazowiecka, Poland
Research Site
Oława, Poland
Research Site
Piotrków, Poland
Research Site
Poznan, Poland
Research Site
Płock, Poland
Research Site
Skierniewice, Poland
Research Site
Sobótka, Poland
Research Site
Sokółka, Poland
Research Site
Szczecin, Poland
Research Site
Tarnów, Poland
Research Site
Torun, Poland
Research Site
Warsaw, Poland
Research Site
Wroclaw, Poland
Research Site
Włocławek, Poland
Research Site
Łańcut, Poland
Research Site
Łęczna, Poland
Research Site
Bacau, Romania
Research Site
Brasov, Romania
Research Site
Brăila, Romania
Research Site
Bucharest, Romania
Research Site
Buzău, Romania
Research Site
Cluj-Napoca, Romania
Research Site
Craiova, Romania
Research Site
Deva, Romania
Research Site
Focşani, Romania
Research Site
Iași, Romania
Research Site
Piteşti, Romania
Research Site
Sibiu, Romania
Research Site
Suceava, Romania
Research Site
Tg. Mures, Romania
Research Site
Timișoara, Romania
Research Site
Gatchina, Russia
Research Site
Kazan', Russia
Research Site
Krasnodar, Russia
Research Site
Moscow, Russia
Research Site
Nizhny Novgorod, Russia
Research Site
Novosibirsk, Russia
Research Site
Perm, Russia
Research Site
Saint Petersburg, Russia
Research Site
Saratov, Russia
Research Site
StPetersburg, Russia
Research Site
Vladikavkaz, Russia
Research Site
Volgograd, Russia
Research Site
Yekaterinburg, Russia
Research Site
Banská Bystrica, Slovakia
Research Site
Bardejov, Slovakia
Research Site
Bratislava, Slovakia
Research Site
Komárno, Slovakia
Research Site
Košice, Slovakia
Research Site
Liptovský Hrádok, Slovakia
Research Site
Liptovský Mikuláš, Slovakia
Research Site
Martin, Slovakia
Research Site
Nitra, Slovakia
Research Site
Partizánske, Slovakia
Research Site
Piešťany, Slovakia
Research Site
Považská Bystrica, Slovakia
Research Site
Prešov, Slovakia
Research Site
Ružomberok, Slovakia
Research Site
Trnava, Slovakia
Research Site
Žilina, Slovakia
Research Site
Alberton, South Africa
Research Site
Bloemfontein, South Africa
Research Site
Cape Town, South Africa
Research Site
Centurion, South Africa
Research Site
Durban, South Africa
Research Site
Gatesville, South Africa
Research Site
George, South Africa
Research Site
Johannesburg, South Africa
Research Site
Kempron Park, South Africa
Research Site
Panorama, South Africa
Research Site
Parow, South Africa
Research Site
Pretoria, South Africa
Research Site
Somerset West, South Africa
Research Site
Soweto, South Africa
Research Site
Worcester, South Africa
Research Site
Bucheon-si, South Korea
Research Site
Busan, South Korea
Research Site
Cheongju-si, South Korea
Research Site
Daegu, South Korea
Research Site
Daejeon, South Korea
Research Site
Gwangju, South Korea
Research Site
Jeonju, South Korea
Research Site
Seongnam-si, South Korea
Research Site
Seoul, South Korea
Research Site
Suwon, South Korea
Research Site
Uijeongbu-si, South Korea
Research Site
Wŏnju, South Korea
Research Site
Almería, Spain
Research Site
Avilés, Spain
Research Site
Barcelona, Spain
Research Site
Bilbao, Spain
Research Site
Don Benito (Badajoz), Spain
Research Site
Hospitalet de Llobregat(Barcel, Spain
Research Site
Madrid, Spain
Research Site
Majadahonda, Spain
Research Site
Málaga, Spain
Research Site
Oviedo, Spain
Research Site
Palma de Mallorca, Spain
Research Site
Sabadell, Spain
Research Site
San Sebastián de los Reyes, Spain
Research Site
Santiago(A Coruña), Spain
Research Site
Seville, Spain
Research Site
Valencia, Spain
Research Site
Eksjö, Sweden
Research Site
Gothenburg, Sweden
Research Site
Jönköping, Sweden
Research Site
Linköping, Sweden
Research Site
Ljungby, Sweden
Research Site
Lund, Sweden
Research Site
Mölndal, Sweden
Research Site
Örebro, Sweden
Research Site
Östersund, Sweden
Research Site
Stockholm, Sweden
Research Site
Sundsvall, Sweden
Research Site
Umeå, Sweden
Research Site
Västerås, Sweden
Research Site
Adana, Turkey (Türkiye)
Research Site
Ankara, Turkey (Türkiye)
Research Site
Istanbul, Turkey (Türkiye)
Research Site
Izmir, Turkey (Türkiye)
Research Site
Malatya, Turkey (Türkiye)
Research Site
Mersin, Turkey (Türkiye)
Research Site
Dnipro, Ukraine
Research Site
Donetsk, Ukraine
Research Site
Kharkiv, Ukraine
Research Site
Kiev, Ukraine
Research Site
Kyiv, Ukraine
Research Site
Lviv, Ukraine
Research Site
Uzhhorod, Ukraine
Research Site
Vinnitsa, Ukraine
Research Site
Zaporozye, Ukraine
Research Site
Airdrie, United Kingdom
Research Site
Antrim, United Kingdom
Research Site
Belfast, United Kingdom
Research Site
Blackpool, United Kingdom
Research Site
Bournemouth, United Kingdom
Research Site
Brighton, United Kingdom
Research Site
Bristol, United Kingdom
Research Site
Coventry, United Kingdom
Research Site
Dundee, United Kingdom
Research Site
East Kilbride, United Kingdom
Research Site
Ely, United Kingdom
Research Site
Hastings, United Kingdom
Research Site
London, United Kingdom
Research Site
Manchester, United Kingdom
Research Site
Middlesbrough, United Kingdom
Research Site
Northampton, United Kingdom
Research Site
Nottingham, United Kingdom
Research Site
Peterborough, United Kingdom
Research Site
Rotherham, United Kingdom
Research Site
Sheffield, United Kingdom
Research Site
Swansea, United Kingdom
Research Site
Torquay, United Kingdom
Research Site
York, United Kingdom
Related Publications (22)
Bonaca MP, Bhatt DL, Cohen M, Steg PG, Storey RF, Jensen EC, Magnani G, Bansilal S, Fish MP, Im K, Bengtsson O, Oude Ophuis T, Budaj A, Theroux P, Ruda M, Hamm C, Goto S, Spinar J, Nicolau JC, Kiss RG, Murphy SA, Wiviott SD, Held P, Braunwald E, Sabatine MS; PEGASUS-TIMI 54 Steering Committee and Investigators. Long-term use of ticagrelor in patients with prior myocardial infarction. N Engl J Med. 2015 May 7;372(19):1791-800. doi: 10.1056/NEJMoa1500857. Epub 2015 Mar 14.
PMID: 25773268RESULTBonaca MP, Im K, Magnani G, Bansilal S, Dellborg M, Storey RF, Bhatt DL, Steg PG, Cohen M, Johanson P, Braunwald E, Sabatine MS. Patient selection for long-term secondary prevention with ticagrelor: insights from PEGASUS-TIMI 54. Eur Heart J. 2022 Dec 21;43(48):5037-5044. doi: 10.1093/eurheartj/ehac402.
PMID: 36367709DERIVEDNatale P, Palmer SC, Saglimbene VM, Ruospo M, Razavian M, Craig JC, Jardine MJ, Webster AC, Strippoli GF. Antiplatelet agents for chronic kidney disease. Cochrane Database Syst Rev. 2022 Feb 28;2(2):CD008834. doi: 10.1002/14651858.CD008834.pub4.
PMID: 35224730DERIVEDBergmark BA, Bhatt DL, Steg PG, Budaj A, Storey RF, Gurmu Y, Kuder JF, Im K, Magnani G, Oude Ophuis T, Hamm C, Spinar J, Kiss RG, Van de Werf FJ, Montalescot G, Johanson P, Braunwald E, Sabatine MS, Bonaca MP. Long-Term Ticagrelor in Patients With Prior Coronary Stenting in the PEGASUS-TIMI 54 Trial. J Am Heart Assoc. 2021 Sep 7;10(17):e020446. doi: 10.1161/JAHA.120.020446. Epub 2021 Aug 21.
PMID: 34423649DERIVEDMagnani G, Ardissino D, Im K, Budaj A, Storey RF, Steg PG, Bhatt DL, Cohen M, Oude Ophius T, Goudev A, Parkhomenko A, Kamensky G, Angiolillo DJ, Lopez-Sendon J, Johanson P, Braunwald E, Sabatine MS, Bonaca MP. Predictors, Type, and Impact of Bleeding on the Net Clinical Benefit of Long-Term Ticagrelor in Stable Patients With Prior Myocardial Infarction. J Am Heart Assoc. 2021 Feb 16;10(4):e017008. doi: 10.1161/JAHA.120.017008. Epub 2021 Feb 9.
PMID: 33559485DERIVEDFurtado RHM, Venkateswaran RV, Nicolau JC, Gurmu Y, Bhatt DL, Storey RF, Steg PG, Magnani G, Goto S, Dellborg M, Kamensky G, Isaza D, Aylward P, Johanson P, Bonaca MP. Caffeinated Beverage Intake, Dyspnea With Ticagrelor, and Cardiovascular Outcomes: Insights From the PEGASUS-TIMI 54 Trial. J Am Heart Assoc. 2020 May 18;9(10):e015785. doi: 10.1161/JAHA.119.015785. Epub 2020 May 15.
PMID: 32410485DERIVEDGencer B, Li XS, Gurmu Y, Bonaca MP, Morrow DA, Cohen M, Bhatt DL, Steg PG, Storey RF, Johanson P, Wang Z, Hazen SL, Sabatine MS. Gut Microbiota-Dependent Trimethylamine N-oxide and Cardiovascular Outcomes in Patients With Prior Myocardial Infarction: A Nested Case Control Study From the PEGASUS-TIMI 54 Trial. J Am Heart Assoc. 2020 May 18;9(10):e015331. doi: 10.1161/JAHA.119.015331. Epub 2020 May 5.
PMID: 32366163DERIVEDFurtado RHM, Nicolau JC, Magnani G, Im K, Bhatt DL, Storey RF, Steg PG, Spinar J, Budaj A, Kontny F, Corbalan R, Kiss RG, Abola MT, Johanson P, Jensen EC, Braunwald E, Sabatine MS, Bonaca MP. Long-term ticagrelor for secondary prevention in patients with prior myocardial infarction and no history of coronary stenting: insights from PEGASUS-TIMI 54. Eur Heart J. 2020 May 1;41(17):1625-1632. doi: 10.1093/eurheartj/ehz821.
PMID: 31811715DERIVEDDellborg M, Bonaca MP, Storey RF, Steg PG, Im KA, Cohen M, Bhatt DL, Oude Ophuis T, Budaj A, Hamm C, Spinar J, Kiss RG, Lopez-Sendon J, Kamensky G, Van de Werf F, Ardissino D, Kontny F, Montalescot G, Johanson P, Bengtsson O, Himmelmann A, Braunwald E, Sabatine MS. Efficacy and safety with ticagrelor in patients with prior myocardial infarction in the approved European label: insights from PEGASUS-TIMI 54. Eur Heart J Cardiovasc Pharmacother. 2019 Oct 1;5(4):200-206. doi: 10.1093/ehjcvp/pvz020.
PMID: 31218354DERIVEDBonaca MP, Wiviott SD, Morrow DA, Steg PG, Hamm C, Bhatt DL, Storey RF, Cohen M, Kuder J, Im K, Magnani G, Budaj A, Nicolau JC, Parkhomenko A, Lopez-Sendon J, Dellborg M, Diaz R, Van de Werf F, Corbalan R, Goudev A, Jensen EC, Johanson P, Braunwald E, Sabatine MS. Reduction in Subtypes and Sizes of Myocardial Infarction With Ticagrelor in PEGASUS-TIMI 54. J Am Heart Assoc. 2018 Nov 20;7(22):e009260. doi: 10.1161/JAHA.118.009260.
PMID: 30571502DERIVEDBansilal S, Bonaca MP, Cornel JH, Storey RF, Bhatt DL, Steg PG, Im K, Murphy SA, Angiolillo DJ, Kiss RG, Parkhomenko AN, Lopez-Sendon J, Isaza D, Goudev A, Kontny F, Held P, Jensen EC, Braunwald E, Sabatine MS, Oude Ophuis AJ. Ticagrelor for Secondary Prevention of Atherothrombotic Events in Patients With Multivessel Coronary Disease. J Am Coll Cardiol. 2018 Feb 6;71(5):489-496. doi: 10.1016/j.jacc.2017.11.050.
PMID: 29406853DERIVEDCavallari I, Morrow DA, Creager MA, Olin J, Bhatt DL, Steg PG, Storey RF, Cohen M, Scirica BS, Piazza G, Goodrich EL, Braunwald E, Sabatine MS, Bonaca MP. Frequency, Predictors, and Impact of Combined Antiplatelet Therapy on Venous Thromboembolism in Patients With Symptomatic Atherosclerosis. Circulation. 2018 Feb 13;137(7):684-692. doi: 10.1161/CIRCULATIONAHA.117.031062. Epub 2017 Oct 30.
PMID: 29084737DERIVEDBonaca MP, Storey RF, Theroux P, Steg PG, Bhatt DL, Cohen MC, Im K, Murphy SA, Magnani G, Ophuis TO, Rudah M, Parkhomenko A, Isaza D, Kamensky G, Goudev A, Montalescot G, Jensen EC, Johanson P, Braunwald E, Sabatine MS. Efficacy and Safety of Ticagrelor Over Time in Patients With Prior MI in PEGASUS-TIMI 54. J Am Coll Cardiol. 2017 Sep 12;70(11):1368-1375. doi: 10.1016/j.jacc.2017.07.768.
PMID: 28882235DERIVEDMagnuson EA, Li H, Wang K, Vilain K, Shafiq A, Bonaca MP, Bhatt DL, Cohen M, Steg PG, Storey RF, Braunwald E, Sabatine MS, Cohen DJ; PEGASUS-TIMI 54 Trial Investigators. Cost-Effectiveness of Long-Term Ticagrelor in Patients With Prior Myocardial Infarction: Results From the PEGASUS-TIMI 54 Trial. J Am Coll Cardiol. 2017 Aug 1;70(5):527-538. doi: 10.1016/j.jacc.2017.05.063.
PMID: 28750695DERIVEDThomas MR, Angiolillo DJ, Bonaca MP, Ajjan RA, Judge HM, Rollini F, Franchi F, Ahsan AJ, Bhatt DL, Kuder JF, Steg PG, Cohen M, Muthusamy R, Sabatine MS, Storey RF. Consistent platelet inhibition with ticagrelor 60 mg twice-daily following myocardial infarction regardless of diabetes status. Thromb Haemost. 2017 May 3;117(5):940-947. doi: 10.1160/TH16-09-0703. Epub 2017 Mar 16.
PMID: 28300867DERIVEDBonaca MP, Goto S, Bhatt DL, Steg PG, Storey RF, Cohen M, Goodrich E, Mauri L, Ophuis TO, Ruda M, Spinar J, Seung KB, Hu D, Dalby AJ, Jensen E, Held P, Morrow DA, Braunwald E, Sabatine MS. Prevention of Stroke with Ticagrelor in Patients with Prior Myocardial Infarction: Insights from PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54). Circulation. 2016 Sep 20;134(12):861-71. doi: 10.1161/CIRCULATIONAHA.116.024637. Epub 2016 Aug 30.
PMID: 27576775DERIVEDBonaca MP, Bhatt DL, Oude Ophuis T, Steg PG, Storey R, Cohen M, Kuder J, Im K, Magnani G, Budaj A, Theroux P, Hamm C, Spinar J, Kiss RG, Dalby AJ, Medina FA, Kontny F, Aylward PE, Jensen EC, Held P, Braunwald E, Sabatine MS. Long-term Tolerability of Ticagrelor for the Secondary Prevention of Major Adverse Cardiovascular Events: A Secondary Analysis of the PEGASUS-TIMI 54 Trial. JAMA Cardiol. 2016 Jul 1;1(4):425-32. doi: 10.1001/jamacardio.2016.1017.
PMID: 27438319DERIVEDHeld P, Himmelmann A, Ditmarsch M. Ticagrelor for the treatment of atherosclerotic disease: insights from the PARTHENON clinical development program. Future Cardiol. 2016 Jul;12(4):405-18. doi: 10.2217/fca-2016-0028. Epub 2016 May 10.
PMID: 27160944DERIVEDBonaca MP, Bhatt DL, Storey RF, Steg PG, Cohen M, Kuder J, Goodrich E, Nicolau JC, Parkhomenko A, Lopez-Sendon J, Dellborg M, Dalby A, Spinar J, Aylward P, Corbalan R, Abola MTB, Jensen EC, Held P, Braunwald E, Sabatine MS. Ticagrelor for Prevention of Ischemic Events After Myocardial Infarction in Patients With Peripheral Artery Disease. J Am Coll Cardiol. 2016 Jun 14;67(23):2719-2728. doi: 10.1016/j.jacc.2016.03.524. Epub 2016 Apr 1.
PMID: 27046162DERIVEDBhatt DL, Bonaca MP, Bansilal S, Angiolillo DJ, Cohen M, Storey RF, Im K, Murphy SA, Held P, Braunwald E, Sabatine MS, Steg PG. Reduction in Ischemic Events With Ticagrelor in Diabetic Patients With Prior Myocardial Infarction in PEGASUS-TIMI 54. J Am Coll Cardiol. 2016 Jun 14;67(23):2732-2740. doi: 10.1016/j.jacc.2016.03.529. Epub 2016 Apr 1.
PMID: 27046160DERIVEDBonaca MP, Bhatt DL, Steg PG, Storey RF, Cohen M, Im K, Oude Ophuis T, Budaj A, Goto S, Lopez-Sendon J, Diaz R, Dalby A, Van de Werf F, Ardissino D, Montalescot G, Aylward P, Magnani G, Jensen EC, Held P, Braunwald E, Sabatine MS. Ischaemic risk and efficacy of ticagrelor in relation to time from P2Y12 inhibitor withdrawal in patients with prior myocardial infarction: insights from PEGASUS-TIMI 54. Eur Heart J. 2016 Apr 7;37(14):1133-42. doi: 10.1093/eurheartj/ehv531. Epub 2015 Oct 21.
PMID: 26491109DERIVEDBonaca MP, Bhatt DL, Braunwald E, Cohen M, Steg PG, Storey RF, Held P, Jensen EC, Sabatine MS. Design and rationale for the Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54 (PEGASUS-TIMI 54) trial. Am Heart J. 2014 Apr;167(4):437-444.e5. doi: 10.1016/j.ahj.2013.12.020. Epub 2014 Jan 6.
PMID: 24655690DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Anders Himmelmann, MD PhD
- Organization
- AstraZeneca AB
Study Officials
- STUDY CHAIR
Eugene Braunwald, MD
The TIMI Study Group
- PRINCIPAL INVESTIGATOR
Marc Sabatine, MD, MPh
The TIMI Study Group
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 9, 2010
First Posted
October 21, 2010
Study Start
October 1, 2010
Primary Completion
December 1, 2014
Study Completion
December 1, 2014
Last Updated
January 25, 2016
Results First Posted
December 9, 2015
Record last verified: 2015-12