Vascular Alteration and Evolution of Cognitive Impairment
ADELAHYDE2
Arterial Function and Structure and Evolution of Cognitive Impairment in Elderly Hypertensive Subjects With Subjective Memory Complaints
1 other identifier
interventional
131
1 country
1
Brief Summary
In the cross sectional study "Adelahyde 1" which took place between 2001 and 2005, the investigators data suggest that vascular alterations may play a role in the setting of subjective memory complaints. This longitudinal study (Adelahyde 2) aims to confirm the role of vascular factors in the evolution of cognitive function and dementia.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Apr 2011
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2011
CompletedFirst Submitted
Initial submission to the registry
April 22, 2011
CompletedFirst Posted
Study publicly available on registry
May 11, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2013
CompletedSeptember 15, 2025
September 1, 2025
2.6 years
April 22, 2011
September 9, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Global memory, visual retention and verbal fluency composite score
up to two years
Secondary Outcomes (2)
vascular exploration
up to two years
white matter hyperintensities by fazekas score.
up to two years
Study Arms (1)
Elderly hypertensive patients with mnemonic subjective
OTHERElderly hypertensive patients with mnemonic subjective without dementia. Interventions : blood sampling brain MRI Assessment of cognitive functions brain MRI and TEP cerebral Electrocardiogram and blood pressure Pulse wave velocity Quality of life questionnaire Urine sample Vascular explorations
Interventions
take a sample of blood, 46 ml
magnetic resonance imaging
Folstein MMSE, Mac Nair scale, Depression (GDS) scale, The Benton Visual Retention Test, Test of verbal fluency, formal and categorical, Trail Making Test, Grober et Buschke scale (RL/RI-16), Apathy Robert scale, Praxis rating Scale .
Electrocardiogramm Blood pressure monitoring
Pulse wave velocity, VWF, IMT
Eligibility Criteria
You may qualify if:
- patient who have participated Adelahyde 1 study
- patient who have signed a consent
- patient who have a social security
You may not qualify if:
- patient who can't understand information letter and who is not under legal protection
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Chu Nancy
Nancy, 54500, France
Related Publications (1)
Ferreira JP, Kearney Schwartz A, Watfa G, Zohra L, Felblinger J, Boivin JM, Bracard S, Hossu G, Verger A, Joly L, Zannad F, Rossignol P, Benetos A. Memory Alterations and White Matter Hyperintensities in Elderly Patients With Hypertension: The ADELAHYDE-2 Study. J Am Med Dir Assoc. 2017 May 1;18(5):451.e13-451.e25. doi: 10.1016/j.jamda.2017.01.008. Epub 2017 Mar 6.
PMID: 28279605BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Athanase BENETOS, professor
CHU NANCY
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Coordinating Investigator
Study Record Dates
First Submitted
April 22, 2011
First Posted
May 11, 2011
Study Start
April 1, 2011
Primary Completion
November 1, 2013
Study Completion
November 1, 2013
Last Updated
September 15, 2025
Record last verified: 2025-09