NCT01220115

Brief Summary

A long term observational study in sickle cell disease will enhance the understanding of the disease patterns, current transfusion practices, treatments and outcomes in sickle cell disease.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
498

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2010

Longer than P75 for all trials

Geographic Reach
1 country

42 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2010

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

October 11, 2010

Completed
2 days until next milestone

First Posted

Study publicly available on registry

October 13, 2010

Completed
3.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2014

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2014

Completed
Last Updated

December 9, 2019

Status Verified

May 1, 2015

Enrollment Period

4.7 years

First QC Date

October 11, 2010

Last Update Submit

December 5, 2019

Conditions

Keywords

sickle cell diseaseiron over load

Outcome Measures

Primary Outcomes (1)

  • Document current treatment patterns, natural history and outcomes in patients with sickle cell disease

    up to 5 years

Secondary Outcomes (2)

  • Data collection

    up to 5 years

  • Measure Sickle cell crisis and hospitalizations

    up to 5 years

Study Arms (3)

No treatment

Patients aged 2 to less than 12

No treatment patients aged 12 to less than 18

Patients aged 12 to less than 18

No treatment Patients greater than 18 years

patients greater than 18 years

Eligibility Criteria

Age2 Years+
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients with Sickle cell disease age 2 years and older

You may qualify if:

  • Male or female patients with HbSS, HbS/beta-thalassemia and HbSC
  • Age \> 2 years old.
  • Written informed consent by the patient or legal guardians, and pediatric assent where indicated.

You may not qualify if:

  • Patients with Sickle Cell trait (HbAS) are not eligible for the study
  • Patient or legal guardians unable or unwilling to give consent, or pediatric assent where indicated.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (42)

Hematology Oncology Services of Arkansas

Little Rock, Arkansas, 72205, United States

Location

Children's Hospital Oakland (CHO)

Oakland, California, 94609, United States

Location

Children's Hospital of Orange County Sickle Cell Disease Center

Orange, California, 92668, United States

Location

Rady Children's Hopsital / UC San Diego University Hospital Sickle Cell Disease Center

San Diego, California, 92123, United States

Location

Hematology Oncology, P.C.

Stamford, Connecticut, 06902, United States

Location

Howard University

Washington D.C., District of Columbia, 20060, United States

Location

Broward Oncology Associates, P.A.

Fort Lauderdale, Florida, 33308, United States

Location

Miami Children's Hospital

Miami, Florida, 33155, United States

Location

Innovative Medical Research

Miami, Florida, 33179, United States

Location

M.D. Anderson Cancer Center Orlando

Orlando, Florida, 32806, United States

Location

All Children's Hospital

St. Petersburg, Florida, 33701, United States

Location

Central Tampa Hematology and Oncology Associates

Tampa, Florida, 33607, United States

Location

St. Joseph Children's Hospital

Tampa, Florida, 33607, United States

Location

University of Illinois at Chicago, Dept of Pediatrics

Chicago, Illinois, 60612, United States

Location

Abington Hematology Oncology Associates, Inc

Oak Lawn, Illinois, 60453, United States

Location

Tulane University School of Medicine

New Orleans, Louisiana, 70112, United States

Location

LSU Department of Pediatrics Children's Hospital

New Orleans, Louisiana, 70118, United States

Location

Johns Hopkins University Division of Hematology

Baltimore, Maryland, 21205, United States

Location

Oncology-Hematology Associates, P.A.

Clinton, Maryland, 20735, United States

Location

Children's Hospital Boston - Harvard

Boston, Massachusetts, 02115, United States

Location

Boston Comprehensive Sickle Cell Center

Boston, Massachusetts, 02118, United States

Location

West Michigan Cancer Center

Kalamazoo, Michigan, 49007-3731, United States

Location

University of Missouri Child Health, Division of Pediatric Hematology/Oncology

Columbia, Missouri, 65212, United States

Location

Children's Mercy Hospital

Kansas City, Missouri, 64108, United States

Location

Research Medical Center

Kansas City, Missouri, 64132, United States

Location

Newark Beth Israel Medical Center

Newark, New Jersey, 07112, United States

Location

Maimonides Medical Center

Brooklyn, New York, 11209, United States

Location

New York Methodist Hospital Dept of Med/Sickle Cell Program

Brooklyn, New York, 11215, United States

Location

Interfaith Medical Center-Comprehensive Sickle Cell Program

Brooklyn, New York, 11238, United States

Location

Cohen Children's Medical Center of NY (CCMC)

New Hyde Park, New York, 11040, United States

Location

Center for Children's Cancer & Blood Disorders

Syracuse, New York, 13210, United States

Location

Presbyterian Hospital Pediatric Sickle Cell Program

Charlotte, North Carolina, 28204, United States

Location

Ohio Region VI Sickle Cell Program

Akron, Ohio, 44308, United States

Location

Cincinnati Children's Medical Center

Cincinnati, Ohio, 45229-3039, United States

Location

The Children's Medical Center of Dayton

Dayton, Ohio, 45404, United States

Location

Medical University of SC-Pediatric Sickle Cell Center

Charleston, South Carolina, 29425, United States

Location

M. Francisco Gonzalez, M.D., P.A.

Columbia, South Carolina, 29203, United States

Location

Diggs-Kraus Sickle Cell Center

Memphis, Tennessee, 38103, United States

Location

Meharry Comprehensive Sickle Cell Center

Nashville, Tennessee, 37208, United States

Location

Sickle Cell Disease and Hemoglobinopathy Clinic Children's Hospital at Vanderbilt

Nashville, Tennessee, 37232-6310, United States

Location

Baylor College of Medicine-Texas Children's Hospital

Houston, Texas, 77030-2399, United States

Location

Peninsula Cancer Institute

Newport News, Virginia, 23601, United States

Location

MeSH Terms

Conditions

Anemia, Sickle Cell

Condition Hierarchy (Ancestors)

Anemia, Hemolytic, CongenitalAnemia, HemolyticAnemiaHematologic DiseasesHemic and Lymphatic DiseasesHemoglobinopathiesGenetic Diseases, InbornCongenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

  • Novartis Pharmaceuticals

    Novartis Pharmaceuticals

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 11, 2010

First Posted

October 13, 2010

Study Start

January 1, 2010

Primary Completion

September 1, 2014

Study Completion

September 1, 2014

Last Updated

December 9, 2019

Record last verified: 2015-05

Locations