Post Cond No Reflow
The POSTCONDITIONING and THE NO REFLOW Phenomenon in Acute Myocardial Infarction
1 other identifier
interventional
44
1 country
1
Brief Summary
After having shown that postconditioning allowed a significant 36% reduction of infarct size as assessed by blood levels of myocardial enzymes in acute myocardial patients, the investigators objective is to assess the effect of postconditioning in acute myocardial infarction (AMI) patients on microvascular obstruction lesions defined by cardiac MRI images.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Apr 2009
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2009
CompletedFirst Submitted
Initial submission to the registry
September 23, 2010
CompletedFirst Posted
Study publicly available on registry
September 24, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2011
CompletedDecember 19, 2025
December 1, 2025
Same day
September 23, 2010
December 13, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Extent of the area of microvascular obstruction
Extent of the area of microvascular obstruction defined on post-gadolinium CMR images realized 48-72 hours after admission in each group
5 days
Secondary Outcomes (1)
Size of the myocardial infarction
5 days
Study Arms (2)
Control
NO INTERVENTION22 controls patients without post conditionment
Intervention
EXPERIMENTAL22 posconditioned patients
Interventions
Direct postconditioning (brief repeated cycle of 4 occlusion and desocclusion of the initially occluded culprit coronary artery) after primary direct stenting.
Eligibility Criteria
You may qualify if:
- Patients \> 18 years old,
- Male or female,
- Presenting first myocardial infarction, with the beginning of pains \< 12 hours,
- Requiring a revascularisation by primary angioplasty or " rescue " (after failure of thrombolysis) on IVA or RCA (not CA).
- Artery guilty with TIMI flow = 0
You may not qualify if:
- cardiac arrest before the angioplasty,
- Cardiogenic shock
- Occlusion of the artery circumflex responsible for the infarction
- Magnetic resonance imaging: contre indication
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hospices Civils de Lyon
Lyon, France
Related Publications (1)
Thuny F, Lairez O, Roubille F, Mewton N, Rioufol G, Sportouch C, Sanchez I, Bergerot C, Thibault H, Cung TT, Finet G, Argaud L, Revel D, Derumeaux G, Bonnefoy-Cudraz E, Elbaz M, Piot C, Ovize M, Croisille P. Post-conditioning reduces infarct size and edema in patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2012 Jun 12;59(24):2175-81. doi: 10.1016/j.jacc.2012.03.026.
PMID: 22676937RESULT
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Pierre CROISILLE, MD
Hospices Civils de Lyon
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 23, 2010
First Posted
September 24, 2010
Study Start
April 1, 2009
Primary Completion
April 1, 2009
Study Completion
March 1, 2011
Last Updated
December 19, 2025
Record last verified: 2025-12