Clinical Outcomes of Angioplasty Postconditioning
Postconditioning and Functional Recovery After Acute Myocardial Infarction
1 other identifier
interventional
91
1 country
1
Brief Summary
We previously demonstrated that postconditioning by coronary angioplasty can decrease infarct size (as measured by cardiac enzyme release) in patients with ongoing acute myocardial infarction. It is currently unknown whether postconditioning actually decreases or simply delays myocardial cell death during reperfusion. In addition, the long term effects of postconditioning on recovery of myocardial contraction remains elusive. The objective of the present study is to determine whether infarct size reduction by angioplasty postconditioning is maintained at 6 months and whether functional recovery is improved at one year post-infarction.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Sep 2005
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2005
CompletedFirst Submitted
Initial submission to the registry
January 5, 2007
CompletedFirst Posted
Study publicly available on registry
January 8, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2008
CompletedMay 28, 2019
March 1, 2010
2.5 years
January 5, 2007
May 23, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Infarct size as measured by cardiac enzymes and MRI at day 5 to 7
during 72 hours after angioplasty, and at day 5 to 7
Secondary Outcomes (1)
Myocardial contraction (LV ejection fraction, wall motion score index, strain rate) measured by echocardiography at 6 month.
at 6 month
Study Arms (2)
1
EXPERIMENTALPost-conditioning during angioplasty
2
ACTIVE COMPARATORstandard angioplasty
Interventions
Eligibility Criteria
You may qualify if:
- Male and female patients, aged more than 18, with suspected first acute myocardial infarction, within 6 hours of the onset of chest pain, with a need for emergency revascularization by angioplasty. Patients must display a fully occluded (TIMI zero flow) culprit coronary artery, absence of visible collaterals and exhibit TIMI flow \>2 after direct stenting by angioplasty.
You may not qualify if:
- Cardiac arrest or cardiogenic shock
- occlusion of the circumflex coronary artery
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Michel Ovize
Lyon, 69677, France
Related Publications (1)
Thibault H, Piot C, Staat P, Bontemps L, Sportouch C, Rioufol G, Cung TT, Bonnefoy E, Angoulvant D, Aupetit JF, Finet G, Andre-Fouet X, Macia JC, Raczka F, Rossi R, Itti R, Kirkorian G, Derumeaux G, Ovize M. Long-term benefit of postconditioning. Circulation. 2008 Feb 26;117(8):1037-44. doi: 10.1161/CIRCULATIONAHA.107.729780. Epub 2008 Feb 11.
PMID: 18268150RESULT
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
michel Ovize, MD
Hospices Civils de Lyon
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
January 5, 2007
First Posted
January 8, 2007
Study Start
September 1, 2005
Primary Completion
March 1, 2008
Study Completion
December 1, 2008
Last Updated
May 28, 2019
Record last verified: 2010-03