NCT01193946|Completed
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Sponsor study identifier
Secondary identifiers
NIH
observational
8
1 country
1
Study Start
May 2010
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
November 2011
Actual (reported)Study Completion
December 2011
Actual (reported)The purpose of this study is to evaluate dietary protein requirements in elderly women aged 80 years and older using the indicator amino acid oxidation technique. Hypothesis to be tested: Protein requirement for elderly women is higher than the estimated average requirement of 0.66 g∙kg-1∙d-1 protein. The recommended protein intake for elderly women is higher than the recommended dietary allowance of 0.80 g∙kg-1∙d-1 protein.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2011
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 2010
Date type not reportedThis date has not been verified as actual or estimated.
July 27, 2010
Actual (reported)September 2, 2010
Actual (reported)November 2011
Actual (reported)December 2011
Actual (reported)dietary protein requirement in older women
Dietary protein requirement is assessed by the subjects' differential response to different dietary protein intake
3 month
There is currently considerable debate regarding the accuracy of the estimated average requirement (EAR) and the recommended dietary allowance (RDA) for older people. Very limited data obtained from older individuals are available to support the assumption that age does not affect protein requirement. Existing method like nitrogen balance has inherent limitations that diminish it from being considered a reference method. Indicator amino acid oxidation technique is emerging as an alternative method to measure dietary protein requirement. It is more accurate and less demanding. The current study will be the first time this technique is used with elderly adults and will provide an important foundation for geriatric nutrition research
Seven dietary protein levels will be tested randomly on the 7 testing days: 0.10, 0.30, 0.60, 0.90, 1.2, 1.5, and 1.8 g∙kg-1∙d-1.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Female Age range: 80 yrs and older Body mass index between 22-30 Weight stable 4.5 kg weight gain or loss within the last 6 month Non-smoking within the last 6 month Ambulatory Clinically normal blood profiles within 10% of clinical normalcy. No diseases or not taking medications known to influence protein or energy metabolism, Willingness and ability to consume food provided and not allergic to phenylalanine
Purdue University
West Lafayette, Indiana, 47907, United States
Tang M, McCabe GP, Elango R, Pencharz PB, Ball RO, Campbell WW. Assessment of protein requirement in octogenarian women with use of the indicator amino acid oxidation technique. Am J Clin Nutr. 2014 Apr;99(4):891-8. doi: 10.3945/ajcn.112.042325. Epub 2014 Jan 15.
plasma samples
Wayne W Campbell, Ph.D.
Purdue University
8 participants (actual enrollment reported by the registry).
First Submitted
July 27, 2010
First Posted
September 2, 2010
Study Start
May 2010
Date type not reportedThis date has not been verified as actual or estimated.
Bariatric Surgery and Weight Loss on Energy Metabolism and Insulin Sensitivity
Contact the study team to confirm eligibility.
Primary Completion
November 2011
Actual (reported)Study Completion
December 2011
Actual (reported)Last Updated
January 17, 2013
Record last verified: 2013-01
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Source: ClinicalTrials.gov.
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