Reducing HIV in Adolescents
RHIVA
A Proof of Concept Cluster Randomised Controlled Trial to Evaluate the Impact of a Cash Incentivised Prevention Intervention to Reduce HIV Infection in High School Learners in Rural KwaZulu-Natal, South Africa
1 other identifier
interventional
3,217
1 country
1
Brief Summary
The purpose of this study is to assess the impact of a cash-incentivised prevention intervention on reducing HIV incidence rates in high-school learners in rural KwaZulu-Natal.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_2 hiv-infections
Started Sep 2010
Typical duration for phase_2 hiv-infections
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 12, 2010
CompletedFirst Posted
Study publicly available on registry
August 25, 2010
CompletedStudy Start
First participant enrolled
September 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2014
CompletedJanuary 19, 2017
January 1, 2017
3.9 years
August 12, 2010
January 18, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
HIV-incidence rates
To evaluate the efficacy of a cash-incentivised prevention intervention in reducing HIV-incidence rates in high-school learners
annually, after every 12 months of follow up
Secondary Outcomes (7)
Academic performance measured as an overall passing grade (50%)
6 monthly
voluntary uptake of HIV testing
annually, after every 12 months of follow up
Substance use patterns
annually, after every 12 months of follow up
Pregnancy rates in female learners
annually, after every 12 months of follow up
Contraceptive use patterns in female learners
annually, after every 12 months of follow up
- +2 more secondary outcomes
Study Arms (2)
Control
ACTIVE COMPARATORAll eligibly enrolled learners in the intervention schools will receive a prevention program delivered by MIET Africa and the KwaZulu-Natal Department of Education. No cash incentives will be paid for meeting milestones
Cash incentive
EXPERIMENTALAll eligibly enrolled learners in the intervention schools will receive a cash incentivised prevention program delivered by MIET Africa and the KwaZulu-Natal Department of Education
Interventions
Cash incentives paid to learners for reaching pre-determined milestones
Standard department of education lifeskills curriculum
Eligibility Criteria
You may qualify if:
- Male or female learner in Grade 9 or 10 in one of the 14 selected schools
- Willing and able to provide informed consent and/or assent to participate in the study
- Willing to provide locator data for home visits if necessary
- Not planning to move to another school or relocate in the next 36 months
- Willing to be finger-printed to verify identity for study procedure purposes
- Willing to participate in this study
- Willing to complete all study procedures
You may not qualify if:
- Refusal by the learner and/or parent or legal guardian to participate in the study.
- Unable to provide necessary informed consents
- Cognitively challenged learners
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Centre for the AIDS Programme of Research in South Africalead
- MIET Africacollaborator
- KwaZulu-Natal Department of Educationcollaborator
- Embassy of the Kingdom of the Netherlands (EKN)collaborator
Study Sites (1)
Vulindlela Clinical Research Site
Durban, KwaZulu-Natal, South Africa
Related Publications (4)
Pettifor AE, Rees HV, Kleinschmidt I, Steffenson AE, MacPhail C, Hlongwa-Madikizela L, Vermaak K, Padian NS. Young people's sexual health in South Africa: HIV prevalence and sexual behaviors from a nationally representative household survey. AIDS. 2005 Sep 23;19(14):1525-34. doi: 10.1097/01.aids.0000183129.16830.06.
PMID: 16135907BACKGROUNDFernald LC, Hou X, Gertler PJ. Oportunidades program participation and body mass index, blood pressure, and self-reported health in Mexican adults. Prev Chronic Dis. 2008 Jul;5(3):A81. Epub 2008 Jun 15.
PMID: 18558031BACKGROUNDHargreaves JR, Glynn JR. Educational attainment and HIV-1 infection in developing countries: a systematic review. Trop Med Int Health. 2002 Jun;7(6):489-98. doi: 10.1046/j.1365-3156.2002.00889.x.
PMID: 12031070BACKGROUNDAyton SG, Pavlicova M, Abdool Karim Q. Identification of adolescent girls and young women for targeted HIV prevention: a new risk scoring tool in KwaZulu Natal, South Africa. Sci Rep. 2020 Aug 3;10(1):13017. doi: 10.1038/s41598-020-69842-x.
PMID: 32747693DERIVED
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Quarraisha Abdool Karim, PhD
Associate Scientific Director
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- NETWORK
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator and Protocol Chair
Study Record Dates
First Submitted
August 12, 2010
First Posted
August 25, 2010
Study Start
September 1, 2010
Primary Completion
August 1, 2014
Study Completion
August 1, 2014
Last Updated
January 19, 2017
Record last verified: 2017-01
Data Sharing
- IPD Sharing
- Will not share