Prevalence of Microcirculatory Alterations in Intensive Care Patients

NCT01179243 | Completed

• 1 other identifier: TPO 702
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 4

Brief Summary

Recent research has focused on the investigation of sublingual microcirculatory alterations in different patient categories, like cardiac surgery and sepsis. The microcirculation plays a pivotal role in tissue oxygenation and can be non invasively visualized by sidestream dark field (SDF) imaging. The objective is to carry out a international multi center study to investigate the prevalence of microcirculatory alterations in intensive care patients. Up to the present time, a comprehensive prevalence study like this has not been carried out.

Conditions

Critical Illness

Keywords

microcirculatory alterations; SDF imaging

Outcome Measures

Primary Outcomes (1)

• microcirculatory alterations related to underlying illness, expressed as - amongst others- microvascular flow index (MFI), proportion of perfused vessels (PPV).

  24 hours

Secondary Outcomes (1)

• microcirculatory alterations related to: hospital/intensive care length of stay mortality severity of illness

  28 days

Study Arms (1)

intensive care patients

no interventions

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

intensive care patients

You may qualify if:

• \> 18
• informed consent

You may not qualify if:

• injury to the maxillofacial area
• recent maxillofacial injury

Sponsors & Collaborators

• Frisius Medisch Centrum: lead

Study Sites (4)

OLVG

Amsterdam, Netherlands

Location

Gelre Ziekenhuis Apeldoorn

Apeldoorn, Netherlands

Location

Medical Centre Leeuwarden

Leeuwarden, 8934 AD, Netherlands

Location

Erasmus MC Rotterdam

Rotterdam, Netherlands

Location

Related Publications (2)

• Vellinga NAR, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, van der Voort PHJ, Dondorp AM, Bafi T, Fries M, Akarsu-Ayazoglu T, Pranskunas A, Hollenberg S, Balestra G, van Iterson M, Sadaka F, Minto G, Aypar U, Hurtado FJ, Martinelli G, Payen D, van Haren F, Holley A, Gomez H, Mehta RL, Rodriguez AH, Ruiz C, Canales HS, Duranteau J, Spronk PE, Jhanji S, Hubble S, Chierego M, Jung C, Martin D, Sorbara C, Bakker J, Ince C; microSOAP study group. Mildly elevated lactate levels are associated with microcirculatory flow abnormalities and increased mortality: a microSOAP post hoc analysis. Crit Care. 2017 Oct 18;21(1):255. doi: 10.1186/s13054-017-1842-7.

  PMID: 29047411 DERIVED

• Vellinga NA, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, Machado FR, Fries M, Akarsu-Ayazoglu T, Pranskunas A, Hollenberg S, Balestra G, van Iterson M, van der Voort PH, Sadaka F, Minto G, Aypar U, Hurtado FJ, Martinelli G, Payen D, van Haren F, Holley A, Pattnaik R, Gomez H, Mehta RL, Rodriguez AH, Ruiz C, Canales HS, Duranteau J, Spronk PE, Jhanji S, Hubble S, Chierego M, Jung C, Martin D, Sorbara C, Tijssen JG, Bakker J, Ince C; microSOAP Study Group. International study on microcirculatory shock occurrence in acutely ill patients. Crit Care Med. 2015 Jan;43(1):48-56. doi: 10.1097/CCM.0000000000000553.

  PMID: 25126880 DERIVED

MeSH Terms

Conditions

Critical Illness

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• E.C. Boerma, MD, PhD

  Medical Centre Leeuwarden, the Netherlands

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD PhD

Study Record Dates

• First Submitted: August 3, 2010
• First Posted: August 11, 2010
• Study Start: September 1, 2011
• Primary Completion: December 1, 2011
• Study Completion: May 1, 2012
• Last Updated: November 1, 2012

Record last verified: 2012-10

Locations

NL (4)