Radiologic Features of Invasive Pulmonary Aspergillosis

NCT01178177 | Completed DMC

• 1 other identifier: IPA -HEM vs SOT-2010
• Study Type: observational
• Target: 130
• Locations: 0 countries
• Sites: N/A

Brief Summary

Invasive pulmonary aspergillosis (IPA) is an opportunistic infection that primarily affects recipients of solid organ transplants (SOTs) and patients with chemotherapy- induced neutropenia.Although both of these populations are at high risk for IPA, they differ with regards to the specific defects in host defense mechanisms that increase their risk for IPA. Chemotherapy- induced neutropenia is the principal defect affecting patients with hematologic malignancies, whereas transplant recipients tend to have dysfunctional T cells and phagocytes, as a result of immunosuppressive drug therapy. Thus, the patterns of IPA-related infection and inflammation may differ according to the type of underlying immune defect. Although the clinical and radiological features of IPA in patients with neutropenia have been extensively studied, little is known about the characteristics of IPA in SOT recipients. The investigators therefore compared the IPA- related clinical and radiological findings in SOT recipients with those of neutropenic patients.

Conditions

Hematologic Disease; Solid Organ Transplantation

Keywords

Invasive pulmonary aspergillosis; Solid organ transplantation; Hematologic disease

Study Arms (2)

SOT recipients

solid organ transplant recipients with invasive pulmonary aspergillosis

Hematologic disease

Hematologic disease patients with invasive pulmonary aspergillosis

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All adult patients who are diagnosed with invasive pulmonary aspergillosis (IPA)between January 2008 and February 2010.

You may qualify if:

• IPA cases with solid organ transplant recipients and hematologic disease patients
• proven and probable invasive pulmonary aspergillosis by modified EORTC/MSG criteria

You may not qualify if:

• under 16 years old
• possible cases of invasive pulmonary aspergillosis

Sponsors & Collaborators

• Asan Medical Center: lead

Related Publications (1)

• Park SY, Lim C, Lee SO, Choi SH, Kim YS, Woo JH, Song JW, Kim MY, Chae EJ, Do KH, Song KS, Seo JB, Kim SH. Computed tomography findings in invasive pulmonary aspergillosis in non-neutropenic transplant recipients and neutropenic patients, and their prognostic value. J Infect. 2011 Dec;63(6):447-56. doi: 10.1016/j.jinf.2011.08.007. Epub 2011 Aug 16.

  PMID: 21854805 RESULT

MeSH Terms

Conditions

Hematologic Diseases; Invasive Pulmonary Aspergillosis

Condition Hierarchy (Ancestors)

Hemic and Lymphatic Diseases; Pulmonary Aspergillosis; Aspergillosis; Mycoses; Bacterial Infections and Mycoses; Infections; Invasive Fungal Infections; Lung Diseases, Fungal; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Sung-Han Kim, MD

  Department of Infectious Diseases, Asan Medical Center

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistantant Professor

Study Record Dates

• First Submitted: August 9, 2010
• First Posted: August 10, 2010
• Study Start: January 1, 2008
• Primary Completion: February 1, 2010
• Study Completion: February 1, 2010
• Last Updated: May 16, 2013

Record last verified: 2013-05