Immune Response to Influenza Vaccination

NCT00551837 | Completed

• 1 other identifier: 2006-12-14
• Study Type: observational
• Target: 82
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study is to evaluate the immune response to a routine influenza vaccination. Influenza vaccination is given as part of routine standard of care in these individuals and is not part of the study protocol. The study will evaluate for a change in response to common antigens over time after influenza vaccination to determine if changes are related to the development of chronic rejection after solid-organ transplantation. We hypothesize that the influenza vaccine contributes to the alloreactivity of T cells verses common HLA types in the donor pool.

Conditions

Solid Organ Transplantation; Chronic Kidney Disease

Keywords

Lung Transplantation; Kidney Transplnatation; Chroinic Kidney Disease; Influenza

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Lung and kidney transplant recipients, patients with chronic kidney disease and healthy controls

You may qualify if:

• Transplant recipients (lung or kidney) 18 years or older, more than 3 months after transplantation
• Transplant candidates (kidney) 18 years or older, to recieve influenza vaccination
• Healthy volunteers to receive influenza vaccination

You may not qualify if:

• Under 18 years of age
• Pregnant
• Medical contraindication for vaccine
• Transplant recipients receiving acute rejection therapy within one month
• Healthy volunteers with autoimmune disease or medications to mediate immune function
• Receipt of live, attenuated influenza vaccine, instead of injectable vaccine

Sponsors & Collaborators

• The Cleveland Clinic: lead
• University Hospitals Cleveland Medical Center: collaborator

MeSH Terms

Conditions

Renal Insufficiency, Chronic; Influenza, Human

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Respiratory Tract Infections; Infections; Orthomyxoviridae Infections; RNA Virus Infections; Virus Diseases; Respiratory Tract Diseases

Study Officials

• Emilio Poggio, MD

  The Cleveland Clinic

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 30, 2007
• First Posted: October 31, 2007
• Study Start: November 1, 2006
• Primary Completion: April 1, 2008
• Study Completion: May 1, 2008
• Last Updated: October 24, 2017

Record last verified: 2017-10