Transformation of Somatosensory and Visual Coordinate Systems

NCT01177462 | Unknown DMC

• 1 other identifier: CMRPG590021G
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

Manipulation of object is a multisensory experience that includes tactile motion between the object and the fingerpad, visual motion elicited by the motion the object and the movement of the hand, and the active motor commend to control upper limb and hand conformation. It remains to be determined how such a complex interaction between touch and vision could be achieved effortlessly. In the present study, we will investigate how the motion information is transformed between touch and vision using the most novel approaches in human psychophysics, neuropsychology and monkey neurophysiology. Specifically, we will present tactile motion on primate fingerpads using a recently developed ball stimulator with a design in which we vary the direction of motion with respect to the skin surface and also vary the hand conformation and position. This setup allows us to systematically sample the possible scenarios involving coordinate transformation between the somatosensory and visual systems in conditions that could occur in hand exploration and object manipulation in daily life. We will present these tactile stimuli on normal human subject as well as stroke patients such as patients with spatial hemineglect. Finally, we will record from macaque monkeys in cortical areas that are thought to underlie the transformation of coordinates, such as the primary somatosensory cortex and posterior parietal cortex. The results of the present study will contribute to the understanding of multisensory integration and the rehabilitation for patients with impaired use of spatial information.

Conditions

Stroke

Keywords

coordinate system; normal

Outcome Measures

Primary Outcomes (1)

• Perceived direction of tactile motion

  Detail description for time frame of assessment: (1) for stroke patients, the assessment will be performed "in average" 6 months after the onset of stroke (2) for normal subjects: assessment will be done when the subject is willing to participate (3) the subject might come to the lab more than once if the experiment can not be completed in one session Assessment: We present tactile motion using tactile stimulators to (1)different digits (2)different hand conformations and (3) different hand positions relative to the trunk

  Once; specifically for stroke patients, 6 months after the onset of stroke

Study Arms (3)

hemineglect stroke patients

Stroke patients with hemineglect

Control stroke patients

Stroke patients without hemineglect

Normal control

Normal subjects

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

We will recruit 40 normal healthy adult subjects (equal to and more than 18 years old); the exclusion criteria are subjects with brain pathology, peripheral neuropathy and limb amputation. We will also recruit 50 stroke patients, the including criteria are stroke patients with stable medical condition and being capable of receiving the evaluations. In this group, stroke patients with peripheral neuropathy, and unstable medical condition.

You may qualify if:

• stroke patients
• stable medical condition
• can cooperate in evaluation

You may not qualify if:

• peripheral neuropathy
• limb ambulation

Sponsors & Collaborators

• Chang Gung Memorial Hospital: lead

Study Sites (1)

Chang Gung Memorial Hospital

Taoyuan, Taiwan, 333, Taiwan

RECRUITING

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Yu-Cheng Pei, MD PhD

  Chang Gung Memorial Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Attending Physician

Study Record Dates

• First Submitted: July 29, 2010
• First Posted: August 9, 2010
• Study Start: March 1, 2011
• Primary Completion: December 1, 2014
• Last Updated: September 25, 2013

Record last verified: 2013-09

Locations

TW (1)