Regulation of Endothelial Progenitor Cells by Short-Term Exercise

NCT01169831 | Completed DMC

• 1 other identifier: HP-00045413
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Endothelial Progenitor Cells (EPCs) are circulating cells released from bone marrow which are important for maintaining cardiovascular health. The prevalence of cardiovascular disease in older adults is associated with reduced circulating EPC numbers. Studies have shown reduced EPC number and function in old vs. young individuals, and endurance exercise training increases EPC number and function in young adults. Oxidative stress adversely affects endothelial cells and preliminary evidence indicates that oxidative stress negatively affects EPC function. Conversely, regular exercise reduces markers of oxidative stress and may enhance EPC function in older adults. The investigators hypothesize that older endurance-trained athletes and matched sedentary individuals will have markedly divergent EPC function and that altering the physical activity levels of both groups will move them to intermediate points between these two extremes. The investigators also propose that the investigators can "mimic" the effect of exercise training on EPC function in cell culture by altering intracellular levels of a key enzyme and a signaling molecule which the investigators have shown to regulate EPC function with respect to exercise training in young individuals.

Conditions

Aging; Exercise; Cardiovascular Disease

Outcome Measures

Primary Outcomes (2)

• Baseline Endothelial progenitor cell number

  Day 1

• Final Endothelial Progenitor Cell Number

  Day 15

Secondary Outcomes (2)

• Baseline Endothelial Reactivity

  Day 1

• Final Endothelial Reactivity

  Day 15

Study Arms (2)

Sedentary Older Adults

EXPERIMENTAL

Other: Exercise Training

Older Endurance Athletes

EXPERIMENTAL

Other: Exercise Cessation

Interventions

Exercise Training OTHER

2 weeks of daily aerobic exercise training

Sedentary Older Adults

Exercise Cessation OTHER

Stopping all exercise for 2 weeks

Older Endurance Athletes

Eligibility Criteria

• Age: 50 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• years of age, BMI = 18-35 kg/m2, non-smoking, women must be postmenopausal

You may not qualify if:

• history of cardiovascular/cerebrovascular disease, diabetes, cancer, renal, liver disease, HIV; uncontrolled hyperlipidemia/hypertension

Sponsors & Collaborators

• Baltimore VA Medical Center: lead
• University of Maryland, Baltimore: collaborator
• University of Maryland, College Park: collaborator

Study Sites (1)

University of Maryland, Baltimore & Baltimore VA Medical Center

Baltimore, Maryland, 21201, United States

Location

MeSH Terms

Conditions

Motor Activity; Cardiovascular Diseases

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Steven J Prior, Ph.D.

  University of Maryland, Baltimore

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: FED
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: July 23, 2010
• First Posted: July 26, 2010
• Study Start: July 1, 2011
• Primary Completion: November 1, 2014
• Study Completion: July 31, 2024
• Last Updated: August 22, 2024

Record last verified: 2024-08

Locations

US (1)