Neurophysiological Reserve With Caffeine Manipulation

NCT01167478 | Completed

• 2 other identifiers: EEFE0262010/01317-0
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this study is to verify if there is a neurophysiologic reserve when caffeine and placebo perceived as caffeine are manipulated in closed- and opened-loop exercises. Parameters of excitability level of skeletal muscle and Central Nervous System (CNS), and peripheral metabolism will be measured

Conditions

Caffeine; Placebo

Keywords

Exercise; Caffeine; Reserve

Outcome Measures

Primary Outcomes (2)

• Neurophysiological reserve evidenced by caffeine

  The time to cover a 4-km trial (closed-loop) or the time to exhaustion in an incremental intensity test (opened-loop) can show if the caffeine manipulation affects the performance. In addition, measures of CNS excitability such as EMG during the closed-loop exercise or at the exhaustion point in the opened-loop exercise, and measures such as the amplitude of H reflex, the rate of increase in H reflex/M wave relationship, can indicate if some central or peripheral alteration occurred during the exercises.

  Immediately after the administration (around 10 minutes)

• Neurophysiological reserve evidenced by caffeine

  The time to cover a 4-km trial (closed-loop) or the time to exhaustion in an incremental intensity test (opened-loop) can show if the placebo manipulation affects the performance. In addition, measures of CNS excitability such as EMG during the closed-loop exercise or at the exhaustion point in the opened-loop exercise, and measures such as the amplitude of H reflex, the rate of increase in H reflex/M wave relationship, can indicate if some central or peripheral alteration ocurred during the exercises.

  Immediately after the administration (around 10 minutes)

Secondary Outcomes (1)

• Neurophysiological reserve evidenced by placebo

  Immediately after the administration (around 10 minutes)

Study Arms (1)

Caffeine

EXPERIMENTAL

Dietary Supplement: Caffeine

Interventions

Caffeine DIETARY_SUPPLEMENT

After ingestion of 6 mg.kg-1 of body mass of caffeine, subjects will perform the one exercise trial.

Caffeine

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• trained cyclists
• trained in long distance races

You may not qualify if:

• Maximum oxygen uptake lower than 55 ml/kg/min

Sponsors & Collaborators

• University of Sao Paulo: lead
• Fundação de Amparo à Pesquisa do Estado de São Paulo: collaborator

Study Sites (1)

University of São Paulo

São Paulo, São Paulo, 05508-030, Brazil

Location

Related Publications (1)

• Lambert EV, St Clair Gibson A, Noakes TD. Complex systems model of fatigue: integrative homoeostatic control of peripheral physiological systems during exercise in humans. Br J Sports Med. 2005 Jan;39(1):52-62. doi: 10.1136/bjsm.2003.011247.

  PMID: 15618343 BACKGROUND

MeSH Terms

Conditions

Motor Activity

Interventions

Caffeine

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Xanthines; Alkaloids; Heterocyclic Compounds; Purinones; Purines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring

Study Officials

• Carlos Ugrinowitsch, PhD

  University of Sao Paulo

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Post-doctoral

Study Record Dates

• First Submitted: July 21, 2010
• First Posted: July 22, 2010
• Study Start: March 1, 2011
• Primary Completion: June 1, 2011
• Study Completion: September 1, 2011
• Last Updated: December 5, 2014

Record last verified: 2014-12

Locations

BR (1)