Coronary Mortality in South Asians: Aetiologic and Prognostic Effects
CALIBER
Cardiovascular Disease Research Using Linked Bespoke Studies and Electronic Records
1 other identifier
observational
100,000
1 country
1
Brief Summary
The purpose of this study is to determine the extent to which South Asian ethnicity is both an etiologic and prognostic factor for coronary disease, and investigate factors influencing outcomes.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Aug 2009
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2009
CompletedFirst Submitted
Initial submission to the registry
April 16, 2010
CompletedFirst Posted
Study publicly available on registry
July 15, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2010
CompletedFebruary 21, 2011
July 1, 2010
4 months
April 16, 2010
February 18, 2011
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
All-cause mortality
365 days Mortality from all causes from the date of admission
365 days
Secondary Outcomes (1)
all causes in-hospital mortality
length of hospital stay
Study Arms (5)
White population
Indian
Pakistani
Bangladeshi
Other
other South Asian
Eligibility Criteria
ACS registry data (MINAP) - with hospital admission databases (Hospital Episode Statistics (HES)
You may qualify if:
- An aetiological healthy population study, the Whitehall II Study, comprising non-industrial civil servants aged 35-55 years who worked in the London offices of 20 civil service departments at baseline (1985-1988), will be used
- A chest pain clinic cohort of consecutive ambulatory patients with no prior investigations for coronary disease and no prior history of acute coronary syndrome recruited in six rapid access chest pain clinics from 1996-2002
- A coronary angiography cohort of consecutive patients undergoing elective angiography at three centres in London between 1996-1997
- Patients with a record in MINAP between 1 Jan 2003 - latest date available in 2009. Only index MINAP events will be included in the analysis.
- We will exclude any study that covers an ethnic group other than South Asian, studies not on coronary disease and studies that examined cross-sectional mortality or cross-sectional associations of cardiovascular risk factors with populations.
You may not qualify if:
- admitted to hospital with fewer than 25 admissions in given year
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University College, Londonlead
- Barts & The London NHS Trustcollaborator
Study Sites (1)
Clinical Epidemiology Group, Department of Epidemiology & Public Health, UCL
London, WC1E 6BT, United Kingdom
Related Publications (1)
Zaman MJ, Philipson P, Chen R, Farag A, Shipley M, Marmot MG, Timmis AD, Hemingway H. South Asians and coronary disease: is there discordance between effects on incidence and prognosis? Heart. 2013 May;99(10):729-36. doi: 10.1136/heartjnl-2012-302925. Epub 2013 Feb 13.
PMID: 23406688DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
April 16, 2010
First Posted
July 15, 2010
Study Start
August 1, 2009
Primary Completion
December 1, 2009
Study Completion
December 1, 2010
Last Updated
February 21, 2011
Record last verified: 2010-07